Preliminary Favorable Outcome for Medically and Surgically Managed Extensively Drug-Resistant Tuberculosis, France, 2009–2014

We report 20 cases of extensively drug-resistant tuberculosis managed in France. Treatment was individualized and included bedaquiline and linezolid for most patients and surgery in 8 patients. At last follow-up (22 months), 19 patients had achieved conversion from positive to negative on culture te...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 22; no. 3; pp. 518 - 521
Main Authors: Henry, Benoît, Revest, Matthieu, Dournon, Nathalie, Epelboin, Loïc, Mellon, Guillaume, Bellaud, Guillaume, Mordant, Pierre, Le Dû, Damien, Véziris, Nicolas, Bernard, Christine, Morel, Sébastien, Jauréguiberry, Stéphane, Michelet, Christian, Bricaire, François, Tattevin, Pierre, Caumes, Éric
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.03.2016
Centers for Disease Control and Prevention
Subjects:
Adult
Antitubercular agents
Antitubercular Agents - pharmacology
Antitubercular Agents - therapeutic use
Combined Modality Therapy
Dispatch
Drug therapy
extensively drug-resistant tuberculosis
Extensively Drug-Resistant Tuberculosis - epidemiology
Extensively Drug-Resistant Tuberculosis - history
Extensively Drug-Resistant Tuberculosis - therapy
Female
Follow-Up Studies
France - epidemiology
History, 21st Century
Human health and pathology
Humans
Life Sciences
Male
MDR TB
Microbial drug resistance
multidrug-resistant tuberculosis
Mycobacterium tuberculosis - drug effects
Preliminary Favorable Outcome for Medically and Surgically Managed Extensively Drug-Resistant Tuberculosis, France, 2009–2014
Treatment Outcome
Tuberculosis
XDR TB
France
bacteria
XDR TB
tuberculosis
multidrug-resistant tuberculosis
bedaquiline
TB
thoracic surgery
antimicrobial resistance
extensively drug-resistant tuberculosis
tuberculosis and other mycobacteria
MDR TB
France
outcome
ISSN:1080-6040, 1080-6059, 1080-6059
Online Access:Get full text
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Summary:We report 20 cases of extensively drug-resistant tuberculosis managed in France. Treatment was individualized and included bedaquiline and linezolid for most patients and surgery in 8 patients. At last follow-up (22 months), 19 patients had achieved conversion from positive to negative on culture testing. These promising results of comprehensive management obtained in a small series deserve confirmation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2203.151130