DNA repair of oxidative DNA damage in human carcinogenesis: Potential application for cancer risk assessment and prevention

Efficient DNA repair mechanisms comprise a critical component in the protection against human cancer, as indicated by the high predisposition to cancer of individuals with germ-line mutations in DNA repair genes. This includes biallelic germ-line mutations in the MUTYH gene, encoding a DNA glycosyla...

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Veröffentlicht in:	Cancer letters Jg. 266; H. 1; S. 60 - 72
Hauptverfasser:	Paz-Elizur, Tamar, Sevilya, Ziv, Leitner-Dagan, Yael, Elinger, Dalia, Roisman, Laila C., Livneh, Zvi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Ireland Elsevier Ireland Ltd 18.07.2008 Elsevier Limited
Schlagworte:	8-Oxoguanine Animals Comet Assay DNA Damage DNA Glycosylases - metabolism DNA Repair DNA repair enzymatic activity Early detection Early Diagnosis Functional DNA repair assay Guanine - analogs & derivatives Hematology, Oncology and Palliative Medicine Humans Medical research Mice Mutation Neoplasms - diagnosis Neoplasms - enzymology Neoplasms - genetics OGG1 Oxidative stress Risk Assessment Smoking - adverse effects DNA repair enzymatic activity Oxidative stress NSCLC OGG1 PBMC BER Early detection SNP Functional DNA repair assay HCR ROS 8-Oxoguanine NER 95% CI non-small cell lung cancer peripheral blood mononuclear cells single nucleotide polymorphism base excision repair host-cell reactivation 95% confidence interval reactive oxygen species nucleotide excision repair
ISSN:	0304-3835, 1872-7980
Online-Zugang:	Volltext
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