Expression profiles of urbilaterian genes uniquely shared between honey bee and vertebrates

Background Large-scale comparison of metazoan genomes has revealed that a significant fraction of genes of the last common ancestor of Bilateria (Urbilateria) is lost in each animal lineage. This event could be one of the underlying mechanisms involved in generating metazoan diversity. However, the...

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Published in:BMC Genomics Vol. 10; no. 1; p. 17
Main Authors: Matsui, Toshiaki, Yamamoto, Toshiyuki, Wyder, Stefan, Zdobnov, Evgeny M, Kadowaki, Tatsuhiko
Format: Journal Article
Language:English
Published: London Springer Science and Business Media LLC 12.01.2009
BioMed Central
BioMed Central Ltd
BMC
Subjects:
Animal Genetics and Genomics
Animals
Bees
Bees - genetics
Bilateria
Biological diversity
Biological Evolution
Biomedical and Life Sciences
Biotechnology
Brain
Brain - metabolism
Evolution
Gene expression
Gene Expression Profiling
Genes, Insect
Genetic aspects
Genetics
Genomics
Honeybee
info:eu-repo/classification/ddc/576.5
Life Sciences
Mice
Mice - genetics
Microarrays
Microbial Genetics and Genomics
Plant Genetics and Genomics
Proteomics
QH426-470
Research Article
RNA
RNA - genetics
Species Specificity
TP248.13-248.65
United Kingdom
Switzerland
Japan
Tumor Necrosis Factor Receptor Superfamily
Gene Network Interaction
TBLASTN Analysis
Metazoan Genome
Gene Ontology
ISSN:1471-2164, 1471-2164
Online Access:Get full text
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Summary:Background Large-scale comparison of metazoan genomes has revealed that a significant fraction of genes of the last common ancestor of Bilateria (Urbilateria) is lost in each animal lineage. This event could be one of the underlying mechanisms involved in generating metazoan diversity. However, the present functions of these ancient genes have not been addressed extensively. To understand the functions and evolutionary mechanisms of such ancient Urbilaterian genes, we carried out comprehensive expression profile analysis of genes shared between vertebrates and honey bees but not with the other sequenced ecdysozoan genomes (honey bee-vertebrate specific, HVS genes) as a model. Results We identified 30 honey bee and 55 mouse HVS genes. Many HVS genes exhibited tissue-selective expression patterns; intriguingly, the expression of 60% of honey bee HVS genes was found to be brain enriched, and 24% of mouse HVS genes were highly expressed in either or both the brain and testis. Moreover, a minimum of 38% of mouse HVS genes demonstrated neuron-enriched expression patterns, and 62% of them exhibited expression in selective brain areas, particularly the forebrain and cerebellum. Furthermore, gene ontology (GO) analysis of HVS genes predicted that 35% of genes are associated with DNA transcription and RNA processing. Conclusion These results suggest that HVS genes include genes that are biased towards expression in the brain and gonads. They also demonstrate that at least some of Urbilaterian genes retained in the specific animal lineage may be selectively maintained to support the species-specific phenotypes.
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ISSN:1471-2164
1471-2164
DOI:10.1186/1471-2164-10-17