COVID-19 Vaccination reduced pneumonia severity

To investigate the effect of vaccinations and boosters on the severity of COVID-19 pneumonia on CT scans during the period of Delta and Omicron variants. Retrospectively studied were 303 patients diagnosed with COVID-19 between July 2021 and February 2022, who had obtained at least one CT scan withi...

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Veröffentlicht in:European journal of radiology Open Jg. 9; S. 100456
Hauptverfasser: Wada, Noriaki, Li, Yi, Hino, Takuya, Gagne, Staci, Valtchinov, Vladimir I., Gay, Elizabeth, Nishino, Mizuki, Madore, Bruno, Guttmann, Charles R.G., Bond, Sheila, Ishigami, Kousei, Hunninghake, Gary M., Levy, Bruce D., Kaye, Kenneth M., Christiani, David C., Hatabu, Hiroto
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 2022
The Authors. Published by Elsevier Ltd
Elsevier
Schlagworte:
COVID-19
Lung
Original
Pneumonia
Radiology
Vaccination
COVID-19
OP
CT
SARS-CoV-2
Pneumonia
RT-PCR
DAD
Vaccination
Lung
mRNA
GGO
diffuse alveolar damage
ground-glass opacity
organizing pneumonia
reverse transcription-polymerase chain reaction
severe acute respiratory syndrome coronavirus 2
coronavirus disease 2019
messenger ribonucleic acid
GGO, ground-glass opacity
COVID-19, coronavirus disease 2019
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2
mRNA, messenger ribonucleic acid
OP, organizing pneumonia
DAD, diffuse alveolar damage
RT-PCR, reverse transcription-polymerase chain reaction
ISSN:2352-0477, 2352-0477
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Zusammenfassung:To investigate the effect of vaccinations and boosters on the severity of COVID-19 pneumonia on CT scans during the period of Delta and Omicron variants. Retrospectively studied were 303 patients diagnosed with COVID-19 between July 2021 and February 2022, who had obtained at least one CT scan within 6 weeks around the COVID-19 diagnosis (−2 to +4 weeks). The severity of pneumonia was evaluated with a 6-point scale Pneumonia Score. The association between demographic and clinical data and vaccination status (booster/additional vaccination, complete vaccination and un-vaccination) and the difference between Pneumonia Scores by vaccination status were investigated. Of 303 patients (59.4 ± 16.3 years; 178 females), 62 (20 %) were in the booster/additional vaccination group, 117 (39 %) in the complete vaccination group, and 124 (41 %) in the unvaccinated group. Interobserver agreement of the Pneumonia Score was high (weighted kappa score = 0.875). Patients in the booster/additionally vaccinated group tended to be older (P = 0.0085) and have more underlying comorbidities (P < 0.0001), and the Pneumonia Scores were lower in the booster/additionally vaccinated [median 2 (IQR 0–4)] and completely vaccinated groups [median 3 (IQR 1–4)] than those in the unvaccinated group [median 4 (IQR 2–4)], respectively (P < 0.0001 and P < 0.0001, respectively). A multivariable linear analysis adjusted for confounding factors confirmed the difference. Vaccinated patients, with or without booster/additional vaccination, had milder COVID-19 pneumonia on CT scans than unvaccinated patients during the period of Delta and Omicron variants. This study supports the efficacy of the vaccine against COVID-19 from a radiological perspective.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
iPNet; image-based Phenotyping Network
ISSN:2352-0477
2352-0477
DOI:10.1016/j.ejro.2022.100456