Comparison of the preconditioning effect of different exercise training modalities on myocardial ischemia-reperfusion injury

The study of exercise preconditioning can develop strategies to prevent cardiovascular diseases and outline the efficient exercise model. However, the exercise type with the most protective effect against ischemia-reperfusion injury is unknown. In this study, we examined the effects of three kinds o...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one Jg. 18; H. 12; S. e0295169
Hauptverfasser: Mohammadkhani, Reihaneh, Ranjbar, Kamal, Salehi, Iraj, Komaki, Alireza, Zarrinkalam, Ebrahim, Amiri, Parsa
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 05.12.2023
Public Library of Science (PLoS)
Schlagworte:
Angiogenesis
Animal models
Animals
Apoptosis
Biology and Life Sciences
Cardiovascular diseases
Care and treatment
Coronary vessels
Creatine kinase
Creatine Kinase, MB Form
Diagnosis
Endurance
Evaluation
Exercise
Fitness equipment
Fitness training programs
Growth factors
Health aspects
Heart
Infarction
Injury prevention
Intervention
Iran
Ischemia
Ischemic Preconditioning, Myocardial
Kinases
Laboratory animals
Male
Medicine and Health Sciences
Mitochondrial DNA
Mortality
Myocardial ischemia
Myocardial Reperfusion Injury - metabolism
Myocardial Reperfusion Injury - prevention & control
Oxidation resistance
Oxidative stress
Physical fitness
Physical training
Physiology
Preconditioning
Proteins
Rats
Rats, Wistar
Reperfusion
Reperfusion injury
Resistance training
Rodents
Running
Serum levels
Strength training
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A
Veins & arteries
Weight training
Iran
United States > US
ISSN:1932-6203, 1932-6203
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The study of exercise preconditioning can develop strategies to prevent cardiovascular diseases and outline the efficient exercise model. However, the exercise type with the most protective effect against ischemia-reperfusion injury is unknown. In this study, we examined the effects of three kinds of exercise preconditioning on myocardial ischemia-reperfusion in adult rats and explored the possible underlying mechanisms. Male Wistar rats subjected to ten weeks of endurance, resistance, and concurrent training underwent ischemia (30 min) and reperfusion (120 min) induction. Then, infarction size, serum levels of the CK-MB, the redox status, and angiogenesis proteins (VEGF, ANGP-1, and ANGP-2) were measured in the cardiac tissue. Results showed that different exercise training modes have the same reduction effects on infarction size, but ischemia-reperfusion-induced CK-MB was lower in response to endurance training and concurrent training. Furthermore, cardiac VEGF levels increased in all three kinds of exercise preconditioning but ischemia-reperfusion-induced ANGP-1 elevated more in endurance training. The cardiac GPX activity was improved significantly through the resistance and concurrent exercise compared to the endurance exercise. In addition, all three exercise preconditioning models decreased MPO levels, and ischemia reperfusion-induced MDA was lower in endurance and resistance training. Overall, these results indicated that cardioprotection of exercise training against ischemia-reperfusion injury depends on the exercise modality. Cardioprotective effects of aerobic, resistance, and concurrent exercises are due to different mechanisms. The preconditioning effects of endurance training are mediated mainly by pervasive angiogenic responses and resistance training through oxidative stress amelioration. The preconditioning effects of concurrent training rely on both angiogenesis and oxidative stress amelioration.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0295169