Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model

Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Polyphenols are naturally occurring compounds in plant-derived fo...

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Bibliographic Details
Published in:	PloS one Vol. 14; no. 10; p. e0223435
Main Authors:	Lai, Alon, Ho, Lap, Evashwick-Rogler, Thomas W., Watanabe, Hironobu, Salandra, Jonathan, Winkelstein, Beth A., Laudier, Damien, Hecht, Andrew C., Pasinetti, Giulio M., Iatridis, James C.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 02.10.2019 Public Library of Science (PLoS)
Subjects:	Animals Back pain Back Pain - diagnosis Back Pain - drug therapy Back Pain - etiology Back Pain - physiopathology Behavior Behavior, Animal Beverages Biological activity Biology and Life Sciences Biomarkers Care and treatment Chronic illnesses Cytokines Cytokines - genetics Cytokines - metabolism Degeneration Degeneration (Pathology) Diet Dietary Supplements Disease Models, Animal Drinking water Food plants Ganglia, Spinal - metabolism Ganglion cysts Gene expression Hyperalgesia - etiology Hyperalgesia - metabolism Hyperalgesia - physiopathology Immunomodulation Inflammation Inflammation Mediators - metabolism Intervertebral Disc Degeneration - complications Intervertebral discs Laboratory rats Low Back Pain - diagnosis Low Back Pain - drug therapy Low Back Pain - etiology Low Back Pain - physiopathology Male Medical research Medicine Medicine and Health Sciences Neurological diseases Pain Pain Management - methods Pain Measurement Pain perception Phenols (Class of compounds) Plants Polyphenols Polyphenols - administration & dosage Radiography Rats Research and Analysis Methods Safety and security measures Signs and symptoms Surgery Tumor necrosis factor-TNF Water New York United States > US Pennsylvania
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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