Hepatic Macrosteatosis Is Partially Converted to Microsteatosis by Melatonin Supplementation in ob/ob Mice Non-Alcoholic Fatty Liver Disease

Obesity is a common risk factor for non-alcoholic fatty liver disease (NAFLD). Currently, there are no specific treatments against NAFLD. Thus, examining any molecule with potential benefits against this condition emerged melatonin as a molecule that influences metabolic dysfunctions. The aim of thi...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 1; p. e0148115
Main Authors:	Stacchiotti, Alessandra, Favero, Gaia, Lavazza, Antonio, Golic, Igor, Aleksic, Marija, Korac, Aleksandra, Rodella, Luigi Fabrizio, Rezzani, Rita
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 29.01.2016 Public Library of Science (PLoS)
Subjects:	Animal models Animals Antioxidants - pharmacology Apoptosis ATP ATP synthase beta Catenin - genetics beta Catenin - metabolism Biology Biology and Life Sciences Blood glucose Calnexin Calnexin - genetics Calnexin - metabolism Care and treatment Cholesterol Complications Diabetes Diagnosis Diet Disease Models, Animal Disease Progression Drinking behavior Drinking water Endoplasmic reticulum Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - pathology Enzymes Fatty acids Fatty liver Gene Expression Regulation Glycogen Health risks Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Histology Homeostasis Hypoxia Liver Liver - drug effects Liver - metabolism Liver - pathology Liver diseases Male Markers Medical treatment Medicine and Health Sciences Melatonin Melatonin - pharmacology Membranes Metabolism Mice Mice, Obese Microscopy Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Mitochondrial Proton-Translocating ATPases - genetics Mitochondrial Proton-Translocating ATPases - metabolism Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Obesity Obesity - complications Obesity - drug therapy Obesity - metabolism Obesity - pathology Organelles Physiological aspects Physiology Protein Subunits - genetics Protein Subunits - metabolism Proteins Risk factors RNA Polymerase II - genetics RNA Polymerase II - metabolism Rodents Signal Transduction SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism Steatosis Stereology Supplementation Supplements Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism β-Catenin Serbia Italy
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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