Identification of gingerenone A as a novel senolytic compound

Senescent cells accumulate with aging and have been shown to contribute to age-associated diseases and organ dysfunction. Eliminating senescent cells with senolytic drugs has been shown to improve age phenotypes in mouse models and there is some initial evidence that it may improve the health of per...

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Bibliographic Details
Published in:	PloS one Vol. 17; no. 3; p. e0266135
Main Authors:	Moaddel, Ruin, Rossi, Martina, Rodriguez, Stephanie, Munk, Rachel, Khadeer, Mohammed, Abdelmohsen, Kotb, Gorospe, Myriam, Ferrucci, Luigi
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 29.03.2022 Public Library of Science (PLoS)
Subjects:	Age Aging Aging (natural) Amino acids Animal models Animals Apoptosis Atherosclerosis Auroral kilometric radiation Automation Biological products Biology and Life Sciences Cell cycle Cell death Cellular Senescence Chemical compounds Chronic illnesses Cytokines Dasatinib - pharmacology Diarylheptanoids - pharmacology Digital cameras Diseases Fibroblasts Genetics Genomics Ginger Health aspects Ionizing radiation Laboratories Materia medica, Vegetable Medicine and Health Sciences Mice Penicillin Pharmacology Phenotypes Physical Sciences Plant extracts Properties Quercetin Quercetin - pharmacology Research and analysis methods Senescence Zingiber officinale United States Minneapolis Minnesota Milpitas California United States > US Baltimore Maryland
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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