Pleiotropy among Common Genetic Loci Identified for Cardiometabolic Disorders and C-Reactive Protein

Pleiotropic genetic variants have independent effects on different phenotypes. C-reactive protein (CRP) is associated with several cardiometabolic phenotypes. Shared genetic backgrounds may partially underlie these associations. We conducted a genome-wide analysis to identify the shared genetic back...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 3; p. e0118859
Main Authors:	Ligthart, Symen, de Vries, Paul S., Uitterlinden, André G., Hofman, Albert, Franco, Oscar H., Chasman, Daniel I., Dehghan, Abbas
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 13.03.2015 Public Library of Science (PLoS)
Subjects:	Biological effects C-reactive protein C-Reactive Protein - metabolism Cardiovascular disease Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Causation Cholesterol Consortia Coronary vessels Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Epidemiology Fasting Female Gene expression Gene loci Genetic analysis Genetic diversity Genetic Loci - genetics Genetic Pleiotropy Genetic variance Genetics Genome-Wide Association Study Genomes Genomics Glucose Health risks Hepatocyte nuclear factor 4 Humans Hypertension Inflammation Insulin Interleukin 1 Interleukin 6 Interleukin 6 receptors Lipids Loci Low density lipoprotein Meta-analysis Metabolic Diseases - genetics Metabolism Mortality Pleiotropy Polymorphism, Single Nucleotide Preventive medicine Proteins Studies Triglycerides Type 2 diabetes Womens health Working groups Netherlands
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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