Prediction of venous thromboembolism incidence in the general adult population using two published genetic risk scores

Most strategies for prevention of venous thromboembolism focus on preventing recurrent events. Yet, primary prevention might be possible through approaches targeting the whole population or high-risk patients. To inform possible prevention strategies, population-based information on the ability of g...

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Vydáno v:	PloS one Ročník 18; číslo 1; s. e0280657
Hlavní autoři:	Folsom, Aaron R., Tang, Weihong, Hong, Ching-Ping, Rosamond, Wayne D., Lane, John A., Cushman, Mary, Pankratz, Nathan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 30.01.2023 Public Library of Science (PLoS)
Témata:	Adult Arteriosclerosis Atherosclerosis Atherosclerosis - complications Biology and Life Sciences Black People Confidence intervals Diabetes Genetic aspects Genetic markers Genetic research Genetic variation Genomes Health risks Hormone replacement therapy Humans Incidence Lifestyles Medical research Medicine and Health Sciences Medicine, Experimental Middle Aged Population (statistical) Population genetics Prevention Proportional Hazards Models Quality control Quartiles Risk Risk Factors Risk groups Social Sciences Statistical analysis Statistics Thromboembolism Venous Thromboembolism - epidemiology Venous Thromboembolism - genetics United States United States > US
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Most strategies for prevention of venous thromboembolism focus on preventing recurrent events. Yet, primary prevention might be possible through approaches targeting the whole population or high-risk patients. To inform possible prevention strategies, population-based information on the ability of genetic risk scores to identify risk of incident venous thromboembolism is needed. We used proportional hazards regression to relate two published genetic risk scores (273-variants versus 5-variants) with venous thromboembolism incidence in the Atherosclerosis Risk in Communities Study (ARIC) cohort (n = 11,292), aged 45-64 at baseline, drawn from 4 US communities. Over a median of 28 years, ARIC identified 788 incident venous thromboembolism events. Incidence rates rose more than two-fold across quartiles of the 273-variant genetic risk score: 1.7, 2.7, 3.4 and 4.0 per 1,000 person-years. For White participants, age, sex, and ancestry-adjusted hazard ratios (95% confidence intervals) across quartiles were strong [1 (reference), 1.30 (0.99,1.70), 1.85 (1.43,2.40), and 2.58 (2.04,3.28)] but weaker for Black participants [1, 1.05 (0.63,1.75), 1.37 (0.84,2.22), and 1.32 (0.80,2.20)]. The 5-variant genetic risk score showed a less steep gradient, with hazard ratios in Whites of 1, 1.17 (0.89,1.54), 1.48 (1.14,1.92), and 2.18 (1.71,2.79). Models including the 273-variant genetic risk score plus lifestyle and clinical factors had a c-statistic of 0.67. In the general population, middle-aged adults in the highest quartile of either genetic risk score studied have approximately two-fold higher risk of an incident venous thromboembolism compared with the lowest quartile. The genetic risk scores show a weaker association with venous thromboembolism for Black people.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0280657