Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America

Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5-9 years (y) after their baseline examination in three Latin-American c...

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Vydané v:	PloS one Ročník 12; číslo 5; s. e0177032
Hlavní autori:	Pérez-Padilla, Rogelio, Fernandez-Plata, Rosario, Montes de Oca, Maria, Lopez-Varela, Maria Victorina, Jardim, Jose R., Muiño, Adriana, Valdivia, Gonzalo, Menezes, Ana Maria B.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 04.05.2017 Public Library of Science (PLoS)
Predmet:	Accidents Adults Age Aged Air flow Analysis Asthma Biology and Life Sciences Biomass Body mass Body mass index Bronchitis Bronchodilators Care and treatment Chest Chronic obstructive lung disease Chronic obstructive pulmonary disease Cigarette smoking Cigarettes Cities Cohort Studies Colleges & universities Computer programs Cooking Coronary artery disease Diabetes mellitus Diagnosis Diseases Division Dosage and administration Education Epidemiology Ethics Evaluation Exposure Female Forced Expiratory Volume Gases Gastritis Heart Heart diseases Heating Hospitals Humans Hypertension Information dissemination Inventories Latin America Lung diseases Male Mathematical models Medicine Medicine and Health Sciences Metropolitan areas Middle Aged Mortality Multivariate analysis Population Population decline Population studies Protocol (computers) Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary function tests Research and Analysis Methods Respiration Respiratory diseases Respiratory function Respiratory system agents Risk factors Samples Smoke Smoking Statistical analysis Statistics Stroke Studies Surveys Thorax Tuberculosis Latin America Brazil
ISSN:	1932-6203, 1932-6203
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Shrnutí:	Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5-9 years (y) after their baseline examination in three Latin-American cities. Post BronchoDilator (postBD) FEV1 decline in mL/y, as %predicted/y (%P/y) and % of baseline/y (%B/y) was calculated and the influence of age, gender, BMI, baseline lung function, BD response, exacerbations rate evaluated using multivariate models. Expressed in ml/y, the mean annual postBD FEV1 decline was 27 mL (0.22%P, 1.32%B) in patients with baseline COPD and 36 (0.14%P, 1.36%B) in those without. Faster decline (in mL/y) was associated with higher baseline lung function, with significant response to bronchodilators, older age and smoking at baseline, also in women with chronic cough and phlegm, or ≥2 respiratory exacerbations in the previous year, and in men with asthma. Lung function decline in a population-based cohort did not differ in obstructed and non-obstructed individuals, it was proportional to baseline FEV1, and was higher in smokers, elderly, and women with respiratory symptoms.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceptualization: AMM RPP.Data curation: AMM RFP RPP.Formal analysis: RFP RPP.Funding acquisition: AMM MLV JRJ GV.Investigation: AMM MLV JRJ GV MMO RPP.Methodology: AMM RPP RFP.Project administration: AMM MVL GV JRJ AM MMO.Resources: AMM MVL GV JRJ AM.Supervision: AMM RPP MMO GV JRJ MLV AM.Writing – original draft: RPP RFP AMM.Writing – review & editing: RPP AMM RFP JRJ GV MMO AM MLV. Competing Interests: The study was sponsored by ALAT, Boehringer, GSK, and Novartis. This does not alter our adherence to PLOS ONE policies on sharing data and materials, in a public repository. Membership of the PLATINO group is provided in the Acknowledgments
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0177032