Robust Selection Algorithm (RSA) for Multi-Omic Biomarker Discovery; Integration with Functional Network Analysis to Identify miRNA Regulated Pathways in Multiple Cancers

MicroRNAs (miRNAs) play a crucial role in the maintenance of cellular homeostasis by regulating the expression of their target genes. As such, the dysregulation of miRNA expression has been frequently linked to cancer. With rapidly accumulating molecular data linked to patient outcome, the need for...

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Veröffentlicht in:	PloS one Jg. 10; H. 10; S. e0140072
Hauptverfasser:	Sehgal, Vasudha, Seviour, Elena G., Moss, Tyler J., Mills, Gordon B., Azencott, Robert, Ram, Prahlad T.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 27.10.2015 Public Library of Science (PLoS)
Schlagworte:	Algorithms Analysis Apoptosis Binding sites Bioinformatics Biology Biomarkers Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Breast cancer Cancer Computational Biology Data management Data processing Datasets Development and progression Gene expression Gene Expression Regulation, Neoplastic Genomes Genomics Homeostasis Humans Identification methods Integration Medical prognosis MicroRNA MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Neoplasms - genetics Network analysis Normality Ovarian cancer Patients Resampling Risk factors RNA, Messenger - biosynthesis Robustness Suppressors Survival Survival analysis United States United States > US Texas
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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