Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding

Indonesia has the second largest tuberculosis (TB) burden globally. Attempts to scale-up TB control efforts have focused on TB households. However, in most high burden settings, considerable Mycobacterium tuberculosis (Mtb) transmission occurs outside TB households. A better understanding of transmi...

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Vydané v:	PloS one Ročník 16; číslo 8; s. e0256043
Hlavní autori:	Alisjahbana, Bachti, Koesoemadinata, Raspati Cundarani, Hadisoemarto, Panji Fortuna, Lestari, Bony Wiem, Hartati, Sri, Chaidir, Lidya, Huang, Chuan-Chin, Murray, Megan, Hill, Philip Campbell, McAllister, Susan Margaret
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 13.08.2021 Public Library of Science (PLoS)
Predmet:	Analysis Biology and Life Sciences Computer and Information Sciences Consent Contact Tracing - methods Cough Cough - diagnosis Cough - microbiology Diagnosis Disease prevention Disease transmission Disease Transmission, Infectious - prevention & control Epidemiologic Research Design Epidemiology Evaluation Feasibility studies Gene sequencing Health risks Health sciences Hospitals Households Humans Indonesia - epidemiology Infectious diseases Internal medicine Intervention Medical diagnosis Medical schools Medicine Medicine and Health Sciences Microbiological analysis Mycobacterium tuberculosis - isolation & purification Mycobacterium tuberculosis - pathogenicity Neighborhoods Network analysis People and Places Population Prevalence Prevalence studies (Epidemiology) Public health Radiography - methods Risk Factors Signs and symptoms Social networks Social organization Social Sciences Sociodemographics Sputum Study Protocol Supervision Tuberculosis Tuberculosis - diagnosis Tuberculosis - epidemiology Tuberculosis - microbiology Tuberculosis - transmission Urban areas Urban environments Whole genome sequencing Whole Genome Sequencing - methods Indonesia New Zealand Netherlands United States > US Massachusetts
ISSN:	1932-6203, 1932-6203
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Shrnutí:	Indonesia has the second largest tuberculosis (TB) burden globally. Attempts to scale-up TB control efforts have focused on TB households. However, in most high burden settings, considerable Mycobacterium tuberculosis (Mtb) transmission occurs outside TB households. A better understanding of transmission dynamics in an urban setting in Indonesia will be crucial for the TB Control Program in scaling up efforts towards elimination of TB in a more targeted way. Therefore, the study aims to measure TB prevalence and incidence in household contacts and neighbourhoods in the vicinity of known TB cases and to assess their genomic and epidemiological relatedness. Individuals (~1000) living in the same household as a case diagnosed with pulmonary TB (n = 250) or in a neighbouring household (~4500 individuals) will be screened for TB symptoms and by chest x-ray. Two sputum samples will be collected for microbiological analysis from anyone with a productive cough. Any person found to have TB will be treated by the National TB Control Program. All those with no evidence of TB disease will have a repeat screen at 12 months. Whole-genome sequencing (WGS) and social network analysis (SNA) will be conducted on Index cases and contacts diagnosed with TB.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0256043