Associations of plasma clusterin and Alzheimer’s disease-related MRI markers in adults at mid-life: The CARDIA Brain MRI sub-study

Clinical and epidemiological studies of older persons have implicated clusterin in Alzheimer's disease (AD) pathogenesis. In the context of identifying early biomarkers of risk, we examined associations of plasma clusterin and characteristics of AD in middle-aged individuals from the community....

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Veröffentlicht in:	PloS one Jg. 13; H. 1; S. e0190478
Hauptverfasser:	Haight, Thaddeus, Bryan, R. Nick, Meirelles, Osorio, Tracy, Russell, Fornage, Myriam, Richard, Melissa, Nasrallah, Ilya, Yaffe, Kristine, Jacobs, David R., Lewis, Cora, Schreiner, Pamela, Sidney, Stephen, Davatzikos, Christos, Launer, Lenore J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 11.01.2018 Public Library of Science (PLoS)
Schlagworte:	Adults Aging Alzheimer Disease - blood Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer's disease Apolipoproteins Atrophy Biological markers Biology and Life Sciences Biomarkers Biomarkers - blood Brain Brain research Clusterin Clusterin - blood Cognitive ability Coronary artery Coronary vessels Cortex (entorhinal) Cortex (temporal) Diagnosis Enzyme-Linked Immunosorbent Assay Epidemiology Female Genetics Health aspects Hemispheres Humans International conferences Laboratories Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medicine and Health Sciences Middle Aged Neurodegenerative diseases Older people Pathogenesis Plasma Polymorphism, Single Nucleotide Population Preventive medicine Research and Analysis Methods Software Studies Temporal lobe Young adults
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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