Prenylated flavonoid morusin protects against TNBS-induced colitis in rats

Morusin is a prenylated flavonoid isolated from the root bark of Morus alba. Many studies have shown the ability of flavonoids to act as anti-inflammatory agents. The aim of this study was to evaluate the effect of morusin on experimentally colitis induced by 2,4,6-trinitrobenzensulfonic acid in Wis...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 8; p. e0182464
Main Authors:	Vochyánová, Zora, Pokorná, Marie, Rotrekl, Dominik, Smékal, Václav, Fictum, Petr, Suchý, Pavel, Gajdziok, Jan, Šmejkal, Karel, Hošek, Jan
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 10.08.2017 Public Library of Science (PLoS)
Subjects:	Animals Anti-inflammatory agents Antioxidants Bark Biology and Life Sciences Biotechnology Care and treatment Catalase Colitis Colitis - chemically induced Colitis - enzymology Colitis - prevention & control Colon Colon - drug effects Colon - enzymology Colon - pathology Colonoscopy Damage Dosage and administration Enzymes Flavonoids Flavonoids - pharmacology Gelatinase A Gelatinase B Inflammatory bowel disease Inflammatory bowel diseases Inflammatory diseases Interleukin 1 Interleukins Intestine Male Matrix Metalloproteinase 2 - metabolism Matrix metalloproteinases Medicine and Health Sciences Molecular biology Pharmaceutical sciences Pharmacy Prenylation Rats Rats, Wistar Rodents Signal transduction Sulfasalazine Superoxide dismutase Transforming growth factor-b1 Transforming growth factors Trinitrobenzenesulfonic Acid Tumor necrosis factor-TNF Veterinary medicine Czech Republic
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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