Efficient protein production inspired by how spiders make silk

Membrane proteins are targets of most available pharmaceuticals, but they are difficult to produce recombinantly, like many other aggregation-prone proteins. Spiders can produce silk proteins at huge concentrations by sequestering their aggregation-prone regions in micellar structures, where the ver...

Full description

Saved in:

Bibliographic Details
Published in:	Nature communications Vol. 8; no. 1; pp. 15504 - 15
Main Authors:	Kronqvist, Nina, Sarr, Médoune, Lindqvist, Anton, Nordling, Kerstin, Otikovs, Martins, Venturi, Luca, Pioselli, Barbara, Purhonen, Pasi, Landreh, Michael, Biverstål, Henrik, Toleikis, Zigmantas, Sjöberg, Lisa, Robinson, Carol V., Pelizzi, Nicola, Jörnvall, Hans, Hebert, Hans, Jaudzems, Kristaps, Curstedt, Tore, Rising, Anna, Johansson, Jan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23.05.2017 Nature Publishing Group Nature Portfolio
Subjects:	101/28 140/131 631/1647/2230/2233 631/337/470/2284 631/61/338/469 82/16 82/29 82/58 82/80 82/83 Amino acids Animal diseases Animal models Animals Biochemistry Cholecystokinin - chemistry Chromatography Circular Dichroism Dimerization Disease Models, Animal E coli Escherichia coli - metabolism Female Fibroins - biosynthesis Humanities and Social Sciences Hydrogen-Ion Concentration Lung - pathology Magnetic Resonance Spectroscopy Medical Bioscience Medicinsk biovetenskap Micelles Microscopy, Electron, Transmission multidisciplinary Mutagenesis, Site-Directed Mutation Peptides Peptides - chemistry Protein Domains Proteins Rabbits Recombinant Proteins - biosynthesis Respiration Disorders - drug therapy Respiratory diseases Science Science (multidisciplinary) Silk Silk - biosynthesis Spiders Surface-Active Agents - chemistry Surfactants Sweden
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!