Humoral and cell-mediated immune responses after a booster dose of HBV vaccine in HIV-infected children, adolescents and young adults

HBV vaccine induces protective antibodies only in 23-56% of HIV-infected children. The aim of our study is to evaluate the immunologic effects of a booster dose of HBV vaccine in HIV-infected youth. 53 young HIV-infected patients in whom HBV vaccination did not elicit protective Ab titers were enrol...

Full description

Saved in:
Bibliographic Details
Published in:PloS one Vol. 13; no. 2; p. e0192638
Main Authors: Giacomet, Vania, Masetti, Michela, Nannini, Pilar, Forlanini, Federica, Clerici, Mario, Zuccotti, Gian Vincenzo, Trabattoni, Daria
Format: Journal Article
Language:English
Published: United States Public Library of Science 14.02.2018
Public Library of Science (PLoS)
Subjects:
Acquired immune deficiency syndrome
Adolescents
Adults
AIDS
Antibodies
Antigens
Antiretroviral drugs
Biology and Life Sciences
CD4 antigen
CD8 antigen
Children
Drug therapy
Effector cells
Hepatitis
Hepatitis B vaccines
HIV
HIV patients
Human immunodeficiency virus
Immune response
Immune response (cell-mediated)
Immune response (humoral)
Immunity
Immunization
Immunological memory
Immunology
Infections
Interleukin 2
Lymphocytes
Lymphocytes T
Medical research
Medicine and Health Sciences
Memory cells
Parameter modification
Patients
Pediatrics
Physiological aspects
Schedules
Seroconversion
Subgroups
Teenagers
Tumor necrosis factor-α
Vaccination
Vaccines
Viruses
Young adults
Youth
γ-Interferon
Italy
ISSN:1932-6203, 1932-6203
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:HBV vaccine induces protective antibodies only in 23-56% of HIV-infected children. The aim of our study is to evaluate the immunologic effects of a booster dose of HBV vaccine in HIV-infected youth. 53 young HIV-infected patients in whom HBV vaccination did not elicit protective Ab titers were enrolled. All patients were on ART with optimal immunological and viral response. All patients received a booster dose of HBV vaccine (HBVAXPRO 10 μg i.m.). HBV-specific Ab titer, viral load and CD4+ T cells were measured at baseline (T0), T1, T6 and T12 months. In a subgroup of 16 patients HBV-specific cell mediated immune responses were evaluated at baseline, at T1 and T6. The booster dose induced seroconversion in 51% of patients at T1, 57% at T6, and49% at T12; seroconversion rate was significantly correlated with CD4+T cells at T0 and to the CD4 nadir. The booster dose induced HBV-specific cell mediated immunity at T6 mainly in Responders (Rs): Effector Memory CD8+T cells, HBV-specific TNFα-, IFNγ-, granzyme secreting CD8+ T cells and IL2-secreting CD4+ T cells were significantly increased in Rs compared to T0. In Non Responders (NRs), HBV-specific IL2-secreting CD4+ T cells, Central and Effector Memory CD8+ T cells were the only parameters modified at T6. Seroconversion induced by a booster dose of vaccine correlates with the development of T cell immunological memory in HIV-infected patients who did not respond to the standard immunization. Alternate immunization schedules need to be considered in NRs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0192638