Humoral and cell-mediated immune responses after a booster dose of HBV vaccine in HIV-infected children, adolescents and young adults

HBV vaccine induces protective antibodies only in 23-56% of HIV-infected children. The aim of our study is to evaluate the immunologic effects of a booster dose of HBV vaccine in HIV-infected youth. 53 young HIV-infected patients in whom HBV vaccination did not elicit protective Ab titers were enrol...

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Vydáno v:	PloS one Ročník 13; číslo 2; s. e0192638
Hlavní autoři:	Giacomet, Vania, Masetti, Michela, Nannini, Pilar, Forlanini, Federica, Clerici, Mario, Zuccotti, Gian Vincenzo, Trabattoni, Daria
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 14.02.2018 Public Library of Science (PLoS)
Témata:	Acquired immune deficiency syndrome Adolescents Adults AIDS Antibodies Antigens Antiretroviral drugs Biology and Life Sciences CD4 antigen CD8 antigen Children Drug therapy Effector cells Hepatitis Hepatitis B vaccines HIV HIV patients Human immunodeficiency virus Immune response Immune response (cell-mediated) Immune response (humoral) Immunity Immunization Immunological memory Immunology Infections Interleukin 2 Lymphocytes Lymphocytes T Medical research Medicine and Health Sciences Memory cells Parameter modification Patients Pediatrics Physiological aspects Schedules Seroconversion Subgroups Teenagers Tumor necrosis factor-α Vaccination Vaccines Viruses Young adults Youth γ-Interferon Italy
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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Shrnutí:	HBV vaccine induces protective antibodies only in 23-56% of HIV-infected children. The aim of our study is to evaluate the immunologic effects of a booster dose of HBV vaccine in HIV-infected youth. 53 young HIV-infected patients in whom HBV vaccination did not elicit protective Ab titers were enrolled. All patients were on ART with optimal immunological and viral response. All patients received a booster dose of HBV vaccine (HBVAXPRO 10 μg i.m.). HBV-specific Ab titer, viral load and CD4+ T cells were measured at baseline (T0), T1, T6 and T12 months. In a subgroup of 16 patients HBV-specific cell mediated immune responses were evaluated at baseline, at T1 and T6. The booster dose induced seroconversion in 51% of patients at T1, 57% at T6, and49% at T12; seroconversion rate was significantly correlated with CD4+T cells at T0 and to the CD4 nadir. The booster dose induced HBV-specific cell mediated immunity at T6 mainly in Responders (Rs): Effector Memory CD8+T cells, HBV-specific TNFα-, IFNγ-, granzyme secreting CD8+ T cells and IL2-secreting CD4+ T cells were significantly increased in Rs compared to T0. In Non Responders (NRs), HBV-specific IL2-secreting CD4+ T cells, Central and Effector Memory CD8+ T cells were the only parameters modified at T6. Seroconversion induced by a booster dose of vaccine correlates with the development of T cell immunological memory in HIV-infected patients who did not respond to the standard immunization. Alternate immunization schedules need to be considered in NRs.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0192638