MiR-191 Regulates Primary Human Fibroblast Proliferation and Directly Targets Multiple Oncogenes

miRNAs play a central role in numerous pathologies including multiple cancer types. miR-191 has predominantly been studied as an oncogene, but the role of miR-191 in the proliferation of primary cells is not well characterized, and the miR-191 targetome has not been experimentally profiled. Here we...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 5; p. e0126535
Main Authors:	Polioudakis, Damon, Abell, Nathan S., Iyer, Vishwanath R.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 20.05.2015 Public Library of Science (PLoS)
Subjects:	Angiogenesis Apoptosis Brain cancer Breast cancer Cancer Cell Count Cell cycle Cell growth Cell Proliferation Cyclin-Dependent Kinase 9 - genetics Cyclin-Dependent Kinase 9 - metabolism Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Gene expression Gene Expression Regulation Genetic aspects Genomes HEK293 Cells HeLa Cells Humans Identification Immunoprecipitation Kinases Lymphoma Mammals MicroRNA MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Molecular biology Nucleotide sequence Oncogenes Physiological aspects Physiology Primary Cell Culture Proteins Proto-Oncogenes Receptor, Notch2 - genetics Receptor, Notch2 - metabolism Ribonucleic acid Ribosomal Protein S6 Kinases, 90-kDa - genetics Ribosomal Protein S6 Kinases, 90-kDa - metabolism RNA RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA-Induced Silencing Complex - genetics RNA-Induced Silencing Complex - metabolism RNA-mediated interference Signal Transduction Stem cells Synthetic biology Target recognition Thyroid gland Transfection Tumorigenesis Wound healing United States
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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