Actin Inhibition Increases Megakaryocyte Proplatelet Formation through an Apoptosis-Dependent Mechanism

Megakaryocytes assemble and release platelets through the extension of proplatelet processes, which are cytoplasmic extensions that extrude from the megakaryocyte and form platelets at their tips. Proplatelet formation and platelet release are complex processes that require a combination of structur...

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Veröffentlicht in:	PloS one Jg. 10; H. 4; S. e0125057
Hauptverfasser:	Avanzi, Mauro P., Izak, Marina, Oluwadara, Oluwasijibomi E., Mitchell, William Beau
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 14.04.2015 Public Library of Science (PLoS)
Schlagworte:	Actin Actin-depolymerizing protein Actins - antagonists & inhibitors Actins - metabolism Amino Acid Chloromethyl Ketones - pharmacology Analysis Apoptosis Apoptosis - drug effects BAX protein bcl-2 Homologous Antagonist-Killer Protein - genetics bcl-2 Homologous Antagonist-Killer Protein - metabolism bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Bcl-x protein bcl-X Protein - genetics bcl-X Protein - metabolism Biology Blood Blood platelets Blood Platelets - chemistry Blood Platelets - cytology Bridged Bicyclo Compounds, Heterocyclic - toxicity Cancer Caspase Caspases - chemistry Caspases - metabolism CD34 antigen Cells, Cultured Cord blood Cytochrome Cytometry Cytoskeleton Electron microscopy Fetal Blood - cytology Flow cytometry Gene expression Genes Humans Inhibition Kinases Laboratories Megakaryocytes Megakaryocytes - cytology Megakaryocytes - drug effects Megakaryocytes - ultrastructure Microscopy, Electron, Transmission Microscopy, Fluorescence Muscle proteins Platelets Ploidy Polymerase chain reaction Polymerization Polyploidy Proteins Quinolines - pharmacology Real-Time Polymerase Chain Reaction Signaling Stem cells Survival Thiazolidines - toxicity Tips Ultrastructure Umbilical cord
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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