Proton NMR-Based Metabolite Analyses of Archived Serial Paired Serum and Urine Samples from Myeloma Patients at Different Stages of Disease Activity Identifies Acetylcarnitine as a Novel Marker of Active Disease

Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields biomarkers indicative of phenotype that can be used to characterize transitions between health and disease, disease progression and therapeutic responses. The...

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Veröffentlicht in:	PloS one Jg. 8; H. 2; S. e56422
Hauptverfasser:	Lodi, Alessia, Tiziani, Stefano, Khanim, Farhat L., Günther, Ulrich L., Viant, Mark R., Morgan, Gareth J., Bunce, Christopher M., Drayson, Mark T.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 19.02.2013 Public Library of Science (PLoS)
Schlagworte:	Acetylcarnitine - blood Acetylcarnitine - urine Aged Aged, 80 and over Apoptosis Archives Archives & records B cells Best practice Biological products Biology Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - urine Blood Cancer therapies Carnitine Carnitine - blood Carnitine - urine Chemistry Chemotherapy Clinical Trials, Phase III as Topic Development and progression Diagnosis Diagnostic imaging Drug dosages Fatty acids Female Health aspects Humans Magnetic resonance Magnetic Resonance Spectroscopy Male Medical prognosis Medical research Medical treatment Medicine Metabolism Metabolites Metabolome Metabolomics Middle Aged Multicenter Studies as Topic Multiple myeloma Multiple Myeloma - blood Multiple Myeloma - pathology Multiple Myeloma - therapy Multiple Myeloma - urine Multivariate Analysis Neoplasm Staging NMR Nuclear magnetic resonance Nuclear magnetic resonance spectroscopy Patients Pediatrics Procurement Remission Remission Induction Spectroscopy Treatment Outcome Urine United Kingdom > UK United States > US Texas
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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