Expression of pim-1 in Tumors, Tumor Stroma and Tumor-Adjacent Mucosa Co-Determines the Prognosis of Colon Cancer Patients

Provirus integration site for Moloney murine leukemia virus (pim-1) is a proto-oncogene that is linked to the development and progression of several cancers. In this study, we evaluated pim-1 expression in tumors, tumor stroma and tumor-adjacent mucosa together as an independent prognostic factor fo...

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Vydané v:PloS one Ročník 8; číslo 10; s. e76693
Hlavní autori: Peng, Yong-hai, Li, Jian-jun, Xie, Fang-wei, Chen, Jian-fang, Yu, Ying-hao, Ouyang, Xue-nong, Liang, Hou-jie
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Public Library of Science 07.10.2013
Public Library of Science (PLoS)
Predmet:
Adolescent
Adult
Aged
Aged, 80 and over
Analytic hierarchy process
Apoptosis
B cells
Breast cancer
Cancer
Cancer patients
Cell cycle
Clinical trials
Colon
Colon - enzymology
Colon - pathology
Colon cancer
Colonic Neoplasms - enzymology
Colonic Neoplasms - pathology
Colorectal cancer
Humans
Immunohistochemistry
Immunohistochemistry - statistics & numerical data
Kaplan-Meier Estimate
Kinases
Leukemia
Lymphocytes
Male
Medical prognosis
Medical research
Metastasis
Middle Aged
Mucosa
Mucous Membrane - enzymology
Mucous Membrane - pathology
Multivariate Analysis
Neoplasm Staging
Oncology
Patients
Powder injection molding
Prognosis
Proportional Hazards Models
Proto-Oncogene Proteins c-pim-1 - metabolism
Regression analysis
Stem cells
Stroma
Studies
Survival
Tissue Array Analysis - statistics & numerical data
Tumors
Viruses
China
ISSN:1932-6203, 1932-6203
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Shrnutí:Provirus integration site for Moloney murine leukemia virus (pim-1) is a proto-oncogene that is linked to the development and progression of several cancers. In this study, we evaluated pim-1 expression in tumors, tumor stroma and tumor-adjacent mucosa together as an independent prognostic factor for colon cancer patients. The study included 343 colon cancer patients. Immunohistochemical staining was used to detect pim-1. Multivariate cox regression for disease-free survival (DFS) were used to identify independent prognostic factors. Analytic hierarchy process (AHP) was used to calculate the weight of pim-1 in tumors, tumor stroma and tumor-adjacent mucosa in order to obtain a Pim-1 total score (PTS) for recurrence and survival. Kaplan-Meier DFS curves and OS curves for patients with different pim-1 expression levels were compared using the log-rank test. In this study, four independent prognostic factors were identified for colon cancer patients: pim-1 expression in tumors, tumor stroma, tumor-adjacent mucosa, as well as tumor stage. It has been established that clinical stage is an important prognostic factor for colon cancer patients. However, PTS can identify the patients who are likely to recur not only in the whole radical excision group but also within each stage of this group. Based on the results of this study we can conclude that the PTS combined with clinical staging system may be a better predictor of colon cancer patients' prognosis than using the clinical stage system alone. ClinicalTrials.gov Number: ChiCTR-PRCH-12002842.
Bibliografia:ObjectType-Article-1
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: YP JL FX XO HL. Performed the experiments: YP JL FX JC YY. Analyzed the data: YP JL FX JC YY. Contributed reagents/materials/analysis tools: YP JL FX JC YY. Wrote the manuscript: YP JL FX XO HL.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0076693