The Impact of Flap Creation Methods for Sub-Bowman’s Keratomileusis (SBK) on the Central Thickness of Bowman’s Layer

To determine the impact of flap creation methods for sub-Bowman's keratomileusis (SBK) on central Bowman's layer thickness. SBK flaps were made by Moria microkeratome for 20 subjects and by femtosecond (FEMTO) laser for 21 subjects. Corneal sublayer thicknesses were measured by ultra-high...

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Vydáno v:PloS one Ročník 10; číslo 5; s. e0124996
Hlavní autoři: Xu, Zhe, Shen, Meixiao, Hu, Liang, Zhuang, Xiran, Peng, Mei, Hu, Di, Liu, Jing, Wang, Jianhua, Qu, Jia, Lu, Fan
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 04.05.2015
Public Library of Science (PLoS)
Témata:
Adult
Astigmatism
Bowman Membrane - pathology
Bowman Membrane - surgery
Care and treatment
Cataracts
Clinical trials
Complications and side effects
Confidence intervals
Cornea
Corneal diseases
Correlation coefficient
Correlation coefficients
Epithelium
Epithelium, Corneal - pathology
Epithelium, Corneal - surgery
Female
Femtosecond
Femtosecond lasers
Flaps
Humans
Image processing
Image Processing, Computer-Assisted
Image segmentation
Keratomileusis, Laser In Situ
Lasers
Male
Methods
Microscopy
Optical Coherence Tomography
Optometry
Reproducibility
Reproducibility of Results
Researchers
Segmentation
Studies
Surgery
Surgical Flaps
Thickness measurement
Tomography
Tomography, Optical Coherence
Ultrasonic imaging
Variance analysis
Wound healing
ISSN:1932-6203, 1932-6203
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Shrnutí:To determine the impact of flap creation methods for sub-Bowman's keratomileusis (SBK) on central Bowman's layer thickness. SBK flaps were made by Moria microkeratome for 20 subjects and by femtosecond (FEMTO) laser for 21 subjects. Corneal sublayer thicknesses were measured by ultra-high resolution optical coherence tomography before SBK and at 1 day, 1 week, 2 weeks, and 1 month afterwards. Each subject was imaged twice on each visit. Thicknesses of central epithelium, Bowman's layer, flap, and total cornea were calculated using a custom-made automated image processing algorithm. The repeatability of sublayer thickness measurements was tested by the intraclass correlation coefficient (ICC) and by the coefficient of repeatability (CoR) at 1 week post-SBK. ICCs of the Moria and FEMTO groups were ≥ 0.959 and ≥ 0.961 respectively for all sublayer measurements. The segmentation CoRs were less than 6.78% and 5.63% respectively. For both groups, microdistortions were present in the epithelium and Bowman's layer after SKB. The flap thickness of the Moria group was 9.8 μm (95% confidence interval: 4.8 - 14.8 μm) thinner than the FEMTO group one day after SBK (independent samples t-test, P < 0.05). Bowman's layer became thicker by 1.6 ± 1.1 μm and 1.7 ± 1.6 μm one day post-SBK for the Moria and FEMTO groups (repeated ANOVA, P < 0.05) and then remained stable. Corneal and sublayer thickness were similar between the two groups. Central Bowman's layer thickness increased 1 day post-SBK. Flap creation by Moria microkeratome and femtosecond laser did not have significantly different impacts on Bowman's layer thickness following SBK. Chinese Clinical Trial Registry (ChiCTR) NO: ChiCTR-OCH-14004525.
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: ZX MS LH JW JQ FL. Performed the experiments: ZX MS LH XZ MP JL JW JQ FL. Analyzed the data: ZX MS LH XZ MP JL. Contributed reagents/materials/analysis tools: ZX MS LH XZ MP JL. Wrote the paper: ZX MS LH XZ MP DH JL JW JQ FL.
These authors are co-first authors on this work.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0124996