Impact of the Chromatin Remodeling Factor CHD1 on Gut Microbiome Composition of Drosophila melanogaster

The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific genetic factors influence microbiome composition in the fly. Our previous work has indicated that intestinal bacterial load can be affected by ch...

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Vydáno v:	PloS one Ročník 11; číslo 4; s. e0153476
Hlavní autoři:	Sebald, Johanna, Willi, Michaela, Schoberleitner, Ines, Krogsdam, Anne, Orth-Höller, Dorothea, Trajanoski, Zlatko, Lusser, Alexandra
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 19.04.2016 Public Library of Science (PLoS)
Témata:	Acetobacteraceae - physiology Age Aging Analysis Animals Bacteria Bioinformatics Biology and Life Sciences Chromatin Chromatin - genetics Chromatin - physiology Chromatin Assembly and Disassembly - genetics Chromatin remodeling Comparative analysis Deletion mutant Dietary supplements Digestive system Digestive tract DNA-Binding Proteins - genetics Drosophila Drosophila melanogaster Drosophila melanogaster - genetics Drosophila melanogaster - physiology Drosophila Proteins - genetics Ecology and Environmental Sciences Flies Gastrointestinal Microbiome - physiology Gastrointestinal tract Gene deletion Gene expression Gene sequencing Genetic factors Homeostasis Infections Insects Intestinal microflora Intestine Lactobacillus plantarum Lactobacillus plantarum - physiology Medicine and Health Sciences Microbiomes Microbiota Microbiota (Symbiotic organisms) Microbiota - physiology Microorganisms Molecular biology Mutants Next-generation sequencing Physiology Regulatory mechanisms (biology) Research and Analysis Methods RNA, Ribosomal, 16S - genetics rRNA 16S Taxa Transcription Factors - genetics United States > US Austria
ISSN:	1932-6203, 1932-6203
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Abstract	The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific genetic factors influence microbiome composition in the fly. Our previous work has indicated that intestinal bacterial load can be affected by chromatin-targeted regulatory mechanisms. Here we studied a potential role of the conserved chromatin assembly and remodeling factor CHD1 in the shaping of the gut microbiome in Drosophila melanogaster. Using high-throughput sequencing of 16S rRNA gene amplicons, we found that Chd1 deletion mutant flies exhibit significantly reduced microbial diversity compared to rescued control strains. Specifically, although Acetobacteraceae dominated the microbiota of both Chd1 wild-type and mutant guts, Chd1 mutants were virtually monoassociated with this bacterial family, whereas in control flies other bacterial taxa constituted ~20% of the microbiome. We further show age-linked differences in microbial load and microbiota composition between Chd1 mutant and control flies. Finally, diet supplementation experiments with Lactobacillus plantarum revealed that, in contrast to wild-type flies, Chd1 mutant flies were unable to maintain higher L. plantarum titres over time. Collectively, these data provide evidence that loss of the chromatin remodeler CHD1 has a major impact on the gut microbiome of Drosophila melanogaster.
AbstractList	The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific genetic factors influence microbiome composition in the fly. Our previous work has indicated that intestinal bacterial load can be affected by chromatin-targeted regulatory mechanisms. Here we studied a potential role of the conserved chromatin assembly and remodeling factor CHD1 in the shaping of the gut microbiome in Drosophila melanogaster. Using high-throughput sequencing of 16S rRNA gene amplicons, we found that Chd1 deletion mutant flies exhibit significantly reduced microbial diversity compared to rescued control strains. Specifically, although Acetobacteraceae dominated the microbiota of both Chd1 wild-type and mutant guts, Chd1 mutants were virtually monoassociated with this bacterial family, whereas in control flies other bacterial taxa constituted ~20% of the microbiome. We further show age-linked differences in microbial load and microbiota composition between Chd1 mutant and control flies. Finally, diet supplementation experiments with Lactobacillus plantarum revealed that, in contrast to wild-type flies, Chd1 mutant flies were unable to maintain higher L. plantarum titres over time. Collectively, these data provide evidence that loss of the chromatin remodeler CHD1 has a major impact on the gut microbiome of Drosophila melanogaster. The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific genetic factors influence microbiome composition in the fly. Our previous work has indicated that intestinal bacterial load can be affected by chromatin-targeted regulatory mechanisms. Here we studied a potential role of the conserved chromatin assembly and remodeling factor CHD1 in the shaping of the gut microbiome in Drosophila melanogaster. Using high-throughput sequencing of 16S rRNA gene amplicons, we found that Chd1 deletion mutant flies exhibit significantly reduced microbial diversity compared to rescued control strains. Specifically, although Acetobacteraceae dominated the microbiota of both Chd1 wild-type and mutant guts, Chd1 mutants were virtually monoassociated with this bacterial family, whereas in control flies other bacterial taxa constituted ~20% of the microbiome. We further show age-linked differences in microbial load and microbiota composition between Chd1 mutant and control flies. Finally, diet supplementation experiments with Lactobacillus plantarum revealed that, in contrast to wild-type flies, Chd1 mutant flies were unable to maintain higher L. plantarum titres over time. Collectively, these data provide evidence that loss of the chromatin remodeler CHD1 has a major impact on the gut microbiome of Drosophila melanogaster.The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific genetic factors influence microbiome composition in the fly. Our previous work has indicated that intestinal bacterial load can be affected by chromatin-targeted regulatory mechanisms. Here we studied a potential role of the conserved chromatin assembly and remodeling factor CHD1 in the shaping of the gut microbiome in Drosophila melanogaster. Using high-throughput sequencing of 16S rRNA gene amplicons, we found that Chd1 deletion mutant flies exhibit significantly reduced microbial diversity compared to rescued control strains. Specifically, although Acetobacteraceae dominated the microbiota of both Chd1 wild-type and mutant guts, Chd1 mutants were virtually monoassociated with this bacterial family, whereas in control flies other bacterial taxa constituted ~20% of the microbiome. We further show age-linked differences in microbial load and microbiota composition between Chd1 mutant and control flies. Finally, diet supplementation experiments with Lactobacillus plantarum revealed that, in contrast to wild-type flies, Chd1 mutant flies were unable to maintain higher L. plantarum titres over time. Collectively, these data provide evidence that loss of the chromatin remodeler CHD1 has a major impact on the gut microbiome of Drosophila melanogaster.
Audience	Academic
Author	Schoberleitner, Ines Krogsdam, Anne Orth-Höller, Dorothea Lusser, Alexandra Sebald, Johanna Trajanoski, Zlatko Willi, Michaela
AuthorAffiliation	4 Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria 2 Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria 3 I-Med GenomeSeq Core, Biocenter, Medical University of Innsbruck, Innsbruck, Austria 1 Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria Oxford Brookes University, UNITED KINGDOM
AuthorAffiliation_xml	– name: 2 Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria – name: 4 Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria – name: 1 Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria – name: 3 I-Med GenomeSeq Core, Biocenter, Medical University of Innsbruck, Innsbruck, Austria – name: Oxford Brookes University, UNITED KINGDOM
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Copyright	COPYRIGHT 2016 Public Library of Science 2016 Sebald et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2016 Sebald et al 2016 Sebald et al
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: JS AK IS AL. Performed the experiments: JS MW IS AK. Analyzed the data: JS MW IS AK ZT AL. Contributed reagents/materials/analysis tools: DOH. Wrote the paper: JS MW IS AK AL. Competing Interests: The authors have declared that no competing interests exist.
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SubjectTerms	Acetobacteraceae - physiology Age Aging Analysis Animals Bacteria Bioinformatics Biology and Life Sciences Chromatin Chromatin - genetics Chromatin - physiology Chromatin Assembly and Disassembly - genetics Chromatin remodeling Comparative analysis Deletion mutant Dietary supplements Digestive system Digestive tract DNA-Binding Proteins - genetics Drosophila Drosophila melanogaster Drosophila melanogaster - genetics Drosophila melanogaster - physiology Drosophila Proteins - genetics Ecology and Environmental Sciences Flies Gastrointestinal Microbiome - physiology Gastrointestinal tract Gene deletion Gene expression Gene sequencing Genetic factors Homeostasis Infections Insects Intestinal microflora Intestine Lactobacillus plantarum Lactobacillus plantarum - physiology Medicine and Health Sciences Microbiomes Microbiota Microbiota (Symbiotic organisms) Microbiota - physiology Microorganisms Molecular biology Mutants Next-generation sequencing Physiology Regulatory mechanisms (biology) Research and Analysis Methods RNA, Ribosomal, 16S - genetics rRNA 16S Taxa Transcription Factors - genetics
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Title	Impact of the Chromatin Remodeling Factor CHD1 on Gut Microbiome Composition of Drosophila melanogaster
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