Impact of the Chromatin Remodeling Factor CHD1 on Gut Microbiome Composition of Drosophila melanogaster

The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific genetic factors influence microbiome composition in the fly. Our previous work has indicated that intestinal bacterial load can be affected by ch...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	PloS one Ročník 11; číslo 4; s. e0153476
Hlavní autoři:	Sebald, Johanna, Willi, Michaela, Schoberleitner, Ines, Krogsdam, Anne, Orth-Höller, Dorothea, Trajanoski, Zlatko, Lusser, Alexandra
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 19.04.2016 Public Library of Science (PLoS)
Témata:	Acetobacteraceae - physiology Age Aging Analysis Animals Bacteria Bioinformatics Biology and Life Sciences Chromatin Chromatin - genetics Chromatin - physiology Chromatin Assembly and Disassembly - genetics Chromatin remodeling Comparative analysis Deletion mutant Dietary supplements Digestive system Digestive tract DNA-Binding Proteins - genetics Drosophila Drosophila melanogaster Drosophila melanogaster - genetics Drosophila melanogaster - physiology Drosophila Proteins - genetics Ecology and Environmental Sciences Flies Gastrointestinal Microbiome - physiology Gastrointestinal tract Gene deletion Gene expression Gene sequencing Genetic factors Homeostasis Infections Insects Intestinal microflora Intestine Lactobacillus plantarum Lactobacillus plantarum - physiology Medicine and Health Sciences Microbiomes Microbiota Microbiota (Symbiotic organisms) Microbiota - physiology Microorganisms Molecular biology Mutants Next-generation sequencing Physiology Regulatory mechanisms (biology) Research and Analysis Methods RNA, Ribosomal, 16S - genetics rRNA 16S Taxa Transcription Factors - genetics United States > US Austria
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific genetic factors influence microbiome composition in the fly. Our previous work has indicated that intestinal bacterial load can be affected by chromatin-targeted regulatory mechanisms. Here we studied a potential role of the conserved chromatin assembly and remodeling factor CHD1 in the shaping of the gut microbiome in Drosophila melanogaster. Using high-throughput sequencing of 16S rRNA gene amplicons, we found that Chd1 deletion mutant flies exhibit significantly reduced microbial diversity compared to rescued control strains. Specifically, although Acetobacteraceae dominated the microbiota of both Chd1 wild-type and mutant guts, Chd1 mutants were virtually monoassociated with this bacterial family, whereas in control flies other bacterial taxa constituted ~20% of the microbiome. We further show age-linked differences in microbial load and microbiota composition between Chd1 mutant and control flies. Finally, diet supplementation experiments with Lactobacillus plantarum revealed that, in contrast to wild-type flies, Chd1 mutant flies were unable to maintain higher L. plantarum titres over time. Collectively, these data provide evidence that loss of the chromatin remodeler CHD1 has a major impact on the gut microbiome of Drosophila melanogaster.
AbstractList	The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific genetic factors influence microbiome composition in the fly. Our previous work has indicated that intestinal bacterial load can be affected by chromatin-targeted regulatory mechanisms. Here we studied a potential role of the conserved chromatin assembly and remodeling factor CHD1 in the shaping of the gut microbiome in Drosophila melanogaster . Using high-throughput sequencing of 16S rRNA gene amplicons, we found that Chd1 deletion mutant flies exhibit significantly reduced microbial diversity compared to rescued control strains. Specifically, although Acetobacteraceae dominated the microbiota of both Chd1 wild-type and mutant guts, Chd1 mutants were virtually monoassociated with this bacterial family, whereas in control flies other bacterial taxa constituted ~20% of the microbiome. We further show age-linked differences in microbial load and microbiota composition between Chd1 mutant and control flies. Finally, diet supplementation experiments with Lactobacillus plantarum revealed that, in contrast to wild-type flies, Chd1 mutant flies were unable to maintain higher L . plantarum titres over time. Collectively, these data provide evidence that loss of the chromatin remodeler CHD1 has a major impact on the gut microbiome of Drosophila melanogaster . The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific genetic factors influence microbiome composition in the fly. Our previous work has indicated that intestinal bacterial load can be affected by chromatin-targeted regulatory mechanisms. Here we studied a potential role of the conserved chromatin assembly and remodeling factor CHD1 in the shaping of the gut microbiome in Drosophila melanogaster. Using high-throughput sequencing of 16S rRNA gene amplicons, we found that Chd1 deletion mutant flies exhibit significantly reduced microbial diversity compared to rescued control strains. Specifically, although Acetobacteraceae dominated the microbiota of both Chd1 wild-type and mutant guts, Chd1 mutants were virtually monoassociated with this bacterial family, whereas in control flies other bacterial taxa constituted ~20% of the microbiome. We further show age-linked differences in microbial load and microbiota composition between Chd1 mutant and control flies. Finally, diet supplementation experiments with Lactobacillus plantarum revealed that, in contrast to wild-type flies, Chd1 mutant flies were unable to maintain higher L. plantarum titres over time. Collectively, these data provide evidence that loss of the chromatin remodeler CHD1 has a major impact on the gut microbiome of Drosophila melanogaster.The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific genetic factors influence microbiome composition in the fly. Our previous work has indicated that intestinal bacterial load can be affected by chromatin-targeted regulatory mechanisms. Here we studied a potential role of the conserved chromatin assembly and remodeling factor CHD1 in the shaping of the gut microbiome in Drosophila melanogaster. Using high-throughput sequencing of 16S rRNA gene amplicons, we found that Chd1 deletion mutant flies exhibit significantly reduced microbial diversity compared to rescued control strains. Specifically, although Acetobacteraceae dominated the microbiota of both Chd1 wild-type and mutant guts, Chd1 mutants were virtually monoassociated with this bacterial family, whereas in control flies other bacterial taxa constituted ~20% of the microbiome. We further show age-linked differences in microbial load and microbiota composition between Chd1 mutant and control flies. Finally, diet supplementation experiments with Lactobacillus plantarum revealed that, in contrast to wild-type flies, Chd1 mutant flies were unable to maintain higher L. plantarum titres over time. Collectively, these data provide evidence that loss of the chromatin remodeler CHD1 has a major impact on the gut microbiome of Drosophila melanogaster.
Audience	Academic
Author	Schoberleitner, Ines Krogsdam, Anne Orth-Höller, Dorothea Lusser, Alexandra Sebald, Johanna Trajanoski, Zlatko Willi, Michaela
AuthorAffiliation	4 Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria 2 Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria 3 I-Med GenomeSeq Core, Biocenter, Medical University of Innsbruck, Innsbruck, Austria 1 Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria Oxford Brookes University, UNITED KINGDOM
AuthorAffiliation_xml	– name: 2 Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria – name: 4 Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria – name: 1 Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria – name: 3 I-Med GenomeSeq Core, Biocenter, Medical University of Innsbruck, Innsbruck, Austria – name: Oxford Brookes University, UNITED KINGDOM
Author_xml	– sequence: 1 givenname: Johanna surname: Sebald fullname: Sebald, Johanna – sequence: 2 givenname: Michaela surname: Willi fullname: Willi, Michaela – sequence: 3 givenname: Ines surname: Schoberleitner fullname: Schoberleitner, Ines – sequence: 4 givenname: Anne surname: Krogsdam fullname: Krogsdam, Anne – sequence: 5 givenname: Dorothea surname: Orth-Höller fullname: Orth-Höller, Dorothea – sequence: 6 givenname: Zlatko surname: Trajanoski fullname: Trajanoski, Zlatko – sequence: 7 givenname: Alexandra surname: Lusser fullname: Lusser, Alexandra
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27093431$$D View this record in MEDLINE/PubMed
BookMark	eNqNk91q3DAQhU1JaZJt36C0hkJpL3YrWbJs96IQNk2ykBJIf26FLMm2FtlyJbkkb18564R1CKX4wmb0nRnN8cxxdNCZTkbRawhWEGXw09YMtmN61YfwCsAU4Yw8i45ggZIlSQA62Ps-jI6d2wKQopyQF9FhkoECYQSPonrT9oz72FSxb2S8bqxpmVddfC1bI6RWXR2fBcDYeH1xCmPTxeeDj78pbk2pTBskpu2NU16Fo5Dl1Bpn-kZpFrdSs87UzHlpX0bPK6adfDW9F9HPs68_1hfLy6vzzfrkcslJkfhlBpICpZxVRCKOU0iESAUpcsAkKZOS8AwJVghEcGiB5DgXBSJcckEYkhhDtIje7vL22jg6eeQozPIkGdsvArHZEcKwLe2tapm9pYYpehcwtqbMesW1pCBhZSowhJIwXJZJTngiKlCWFSYMgrHal6naULZScNl5y_Qs6fykUw2tzR-Kc0QyNF7mw5TAmt-DdJ62ynGpg3HSDHf3RgiDLCcBffcIfbq7iapZaEB1lQl1-ZiUnuAwIzgbf_wiWj1BhUfIVvEwUJUK8Zng40wQGC9vfM0G5-jm-_X_s1e_5uz7PbaRTPvGGT2M0-Tm4Jt9px8svp_kAOAdEAbTOSurBwQCOi7MvV10XBg6LUyQfX4k48qzsXxwROl_i_8Cy6IbKQ
CitedBy_id	crossref_primary_10_1146_annurev_genet_112618_043650 crossref_primary_10_1016_j_molmet_2019_12_005 crossref_primary_10_1155_2016_6951091 crossref_primary_10_1016_j_chom_2019_02_003 crossref_primary_10_1016_j_tim_2024_05_006 crossref_primary_10_1038_s41684_018_0065_0 crossref_primary_10_3389_fmicb_2017_00738 crossref_primary_10_3389_fnmol_2022_840966 crossref_primary_10_1186_s12263_019_0641_y crossref_primary_10_1073_pnas_1913976117
Cites_doi	10.1016/j.cell.2012.01.035 10.1038/nrmicro2540 10.1371/journal.pone.0148028 10.1146/annurev.immunol.25.022106.141615 10.1371/journal.pone.0061217 10.1016/j.febslet.2014.06.041 10.1126/science.1149357 10.1007/s10577-006-1067-0 10.1016/j.dci.2013.05.005 10.1073/pnas.0502240102 10.1016/j.cmet.2007.06.006 10.1038/nbt1212 10.1093/nar/gkm864 10.1371/journal.pone.0070749 10.1371/journal.pone.0043144 10.1038/ismej.2013.86 10.1093/nar/gkq1298 10.1128/AEM.02120-06 10.1093/bioinformatics/btq461 10.1128/AEM.02206-14 10.1073/pnas.0405207101 10.1038/nature11234 10.1073/pnas.1215849110 10.1038/nrmicro3074 10.1093/bioinformatics/btp636 10.1111/j.1462-2920.2011.02511.x 10.1016/j.cell.2013.12.018 10.1073/pnas.0307605101 10.1126/science.1145339 10.1101/cshperspect.a000224 10.1128/mBio.01117-14 10.1016/j.smim.2011.11.003 10.1371/journal.pone.0009490 10.1016/j.cmet.2011.07.012 10.15252/embj.201488456 10.1128/IAI.01496-06 10.1016/j.chom.2014.11.010 10.1073/pnas.1009906107 10.1038/nmeth.f.303 10.1371/journal.pgen.1002272 10.1101/gad.1827009 10.1128/JB.186.17.5721-5729.2004 10.1099/ijs.0.65778-0 10.1016/j.celrep.2015.08.004 10.1038/nrmicro1978
ContentType	Journal Article
Copyright	COPYRIGHT 2016 Public Library of Science 2016 Sebald et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2016 Sebald et al 2016 Sebald et al
Copyright_xml	– notice: COPYRIGHT 2016 Public Library of Science – notice: 2016 Sebald et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2016 Sebald et al 2016 Sebald et al
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA
DOI	10.1371/journal.pone.0153476
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection ProQuest Health & Medical Collection (NC LIVE) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest Public Health Database (NC LIVE) Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Materials Science & Engineering Collection ProQuest Central (Alumni) One Sustainability ProQuest Central UK/Ireland ProQuest Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Technology Collection ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts ProQuest SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database ProQuest Engineering Database (NC LIVE) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic Agricultural Science Database
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: ProQuest Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General)
DocumentTitleAlternate	Gut Microbiome in Chd1-Mutant Flies
EISSN	1932-6203
ExternalDocumentID	1782205389 oai_doaj_org_article_02ab5d411e6a4bb286c2df0bbf46a101 PMC4836739 4028243281 A453447934 27093431 10_1371_journal_pone_0153476
Genre	Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	United States--US Austria
GeographicLocations_xml	– name: Austria – name: United States--US
GrantInformation_xml	– fundername: ; grantid: DOC Fellowship – fundername: ; grantid: D-110410-022-011 – fundername: ; grantid: START Y275-B12
GroupedDBID	--- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM AAPBV ABPTK N95
ID	FETCH-LOGICAL-c692t-702935caf6e3c4516dd5d6980ae6b2b6c73da9d3642706848d936cecd6a3e4413
IEDL.DBID	7RV
ISICitedReferencesCount	11
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000374541200022&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-6203
IngestDate	Sun Feb 05 03:14:16 EST 2023 Mon Nov 10 04:31:54 EST 2025 Tue Nov 04 01:59:00 EST 2025 Fri Sep 05 10:52:30 EDT 2025 Tue Oct 07 07:41:15 EDT 2025 Sat Nov 29 13:12:50 EST 2025 Sat Nov 29 10:17:57 EST 2025 Wed Nov 26 09:41:03 EST 2025 Wed Nov 26 10:12:32 EST 2025 Thu May 22 21:16:29 EDT 2025 Wed Feb 19 02:33:57 EST 2025 Tue Nov 18 22:28:48 EST 2025 Sat Nov 29 02:46:39 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	4
Language	English
License	This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c692t-702935caf6e3c4516dd5d6980ae6b2b6c73da9d3642706848d936cecd6a3e4413
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: JS AK IS AL. Performed the experiments: JS MW IS AK. Analyzed the data: JS MW IS AK ZT AL. Contributed reagents/materials/analysis tools: DOH. Wrote the paper: JS MW IS AK AL. Competing Interests: The authors have declared that no competing interests exist.
OpenAccessLink	https://www.proquest.com/docview/1782205389?pq-origsite=%requestingapplication%
PMID	27093431
PQID	1782205389
PQPubID	1436336
ParticipantIDs	plos_journals_1782205389 doaj_primary_oai_doaj_org_article_02ab5d411e6a4bb286c2df0bbf46a101 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4836739 proquest_miscellaneous_1783340786 proquest_journals_1782205389 gale_infotracmisc_A453447934 gale_infotracacademiconefile_A453447934 gale_incontextgauss_ISR_A453447934 gale_incontextgauss_IOV_A453447934 gale_healthsolutions_A453447934 pubmed_primary_27093431 crossref_primary_10_1371_journal_pone_0153476 crossref_citationtrail_10_1371_journal_pone_0153476
PublicationCentury	2000
PublicationDate	2016-04-19
PublicationDateYYYYMMDD	2016-04-19
PublicationDate_xml	– month: 04 year: 2016 text: 2016-04-19 day: 19
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco – name: San Francisco, CA USA
PublicationTitle	PloS one
PublicationTitleAlternate	PLoS One
PublicationYear	2016
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	ref35 G Natoli (ref22) 2009; 1 AG Clooney (ref46) 2016; 11 N Vodovar (ref40) 2005; 102 MN Price (ref33) 2010; 5 B Lemaitre (ref1) 2007; 25 (ref29) 2014 A Spor (ref43) 2011; 9 M Rera (ref48) 2012; 109 PA Bron (ref37) 2004; 186 RC Edgar (ref30) 2010; 26 S Morettini (ref27) 2011; 39 F Staubach (ref12) 2013; 8 N Buchon (ref5) 2013; 11 G Sharon (ref38) 2010; 107 JA Chandler (ref11) 2011; 7 JG Caporaso (ref28) 2010; 7 SJ Salipante (ref45) 2014; 80 B Erkosar (ref3) 2014; 588 NA Broderick (ref20) 2014; 5 AY Konev (ref26) 2007; 317 AC-N Wong (ref13) 2013; 7 J-H Ryu (ref9) 2008; 319 (ref14) 2012; 486 G Storelli (ref39) 2011; 14 J Sebald (ref25) 2012; 7 C Ren (ref17) 2007; 6 K Bouazoune (ref24) 2006; 14 I Cleenwerck (ref36) 2008; 58 JC Clemente (ref44) 2012; 148 T Brummel (ref6) 2004; 101 L Guo (ref19) 2014; 156 JE Blum (ref21) 2013; 4 N Vodovar (ref41) 2006; 24 N Buchon (ref18) 2009; 23 K-A Lee (ref2) 2014; 42 RE Ley (ref15) 2008; 6 JG Caporaso (ref32) 2010; 26 PJ McMurdie (ref34) 2013; 8 B Charroux (ref4) 2012; 24 F Bonnay (ref23) 2014; 33 GN Landis (ref47) 2004; 101 V Corby-Harris (ref7) 2007; 73 CNA Wong (ref10) 2011; 13 CR Cox (ref8) 2007; 75 E Pruesse (ref31) 2007; 35 RN Carmody (ref16) 2015; 17 RI Clark (ref42) 2015; 12
References_xml	– volume: 148 start-page: 1258 year: 2012 ident: ref44 article-title: The impact of the gut microbiota on human health: an integrative view publication-title: Cell doi: 10.1016/j.cell.2012.01.035 – volume: 9 start-page: 279 year: 2011 ident: ref43 article-title: Unravelling the effects of the environment and host genotype on the gut microbiome publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro2540 – volume: 11 start-page: e0148028 year: 2016 ident: ref46 article-title: Comparing Apples and Oranges?: Next Generation Sequencing and Its Impact on Microbiome Analysis publication-title: PLoS ONE doi: 10.1371/journal.pone.0148028 – volume: 25 start-page: 697 year: 2007 ident: ref1 article-title: The host defense of Drosophila melanogaster publication-title: Annu Rev Immunol doi: 10.1146/annurev.immunol.25.022106.141615 – volume: 8 start-page: e61217 year: 2013 ident: ref34 article-title: phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data publication-title: PLoS ONE doi: 10.1371/journal.pone.0061217 – volume: 588 start-page: 4250 year: 2014 ident: ref3 article-title: Transient adult microbiota, gut homeostasis and longevity: novel insights from the Drosophila model publication-title: FEBS Lett doi: 10.1016/j.febslet.2014.06.041 – volume: 319 start-page: 777 year: 2008 ident: ref9 article-title: Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila publication-title: Science doi: 10.1126/science.1149357 – volume: 14 start-page: 433 year: 2006 ident: ref24 article-title: ATP-dependent chromatin remodeling complexes in Drosophila publication-title: Chromosome Res doi: 10.1007/s10577-006-1067-0 – volume: 42 start-page: 102 year: 2014 ident: ref2 article-title: Drosophila as a model for intestinal dysbiosis and chronic inflammatory diseases publication-title: Dev Comp Immunol doi: 10.1016/j.dci.2013.05.005 – volume: 102 start-page: 11414 year: 2005 ident: ref40 article-title: Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0502240102 – volume: 6 start-page: 144 year: 2007 ident: ref17 article-title: Increased internal and external bacterial load during Drosophila aging without life-span trade-off publication-title: Cell Metab doi: 10.1016/j.cmet.2007.06.006 – volume: 24 start-page: 673 year: 2006 ident: ref41 article-title: Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila publication-title: Nat Biotechnol doi: 10.1038/nbt1212 – volume: 35 start-page: 7188 year: 2007 ident: ref31 article-title: SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB publication-title: Nucleic Acids Res doi: 10.1093/nar/gkm864 – volume: 8 start-page: e70749 year: 2013 ident: ref12 article-title: Host species and environmental effects on bacterial communities associated with Drosophila in the laboratory and in the natural environment publication-title: PLoS ONE doi: 10.1371/journal.pone.0070749 – volume: 7 start-page: e43144 year: 2012 ident: ref25 article-title: CHD1 Contributes to Intestinal Resistance against Infection by P. aeruginosa in Drosophila melanogaster publication-title: PLoS ONE doi: 10.1371/journal.pone.0043144 – volume: 7 start-page: 1922 year: 2013 ident: ref13 article-title: The inconstant gut microbiota of Drosophila species revealed by 16S rRNA gene analysis publication-title: ISME J doi: 10.1038/ismej.2013.86 – volume: 39 start-page: 3103 year: 2011 ident: ref27 article-title: The chromodomains of CHD1 are critical for enzymatic activity but less important for chromatin localization publication-title: Nucleic Acids Res doi: 10.1093/nar/gkq1298 – volume: 73 start-page: 3470 year: 2007 ident: ref7 article-title: Geographical distribution and diversity of bacteria associated with natural populations of Drosophila melanogaster publication-title: Appl Environ Microbiol doi: 10.1128/AEM.02120-06 – volume: 26 start-page: 2460 year: 2010 ident: ref30 article-title: Search and clustering orders of magnitude faster than BLAST publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq461 – volume: 80 start-page: 7583 year: 2014 ident: ref45 article-title: Performance comparison of Illumina and ion torrent next-generation sequencing platforms for 16S rRNA-based bacterial community profiling publication-title: Appl Environ Microbiol doi: 10.1128/AEM.02206-14 – volume: 101 start-page: 12974 year: 2004 ident: ref6 article-title: Drosophila lifespan enhancement by exogenous bacteria publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0405207101 – volume: 486 start-page: 207 year: 2012 ident: ref14 article-title: Structure, function and diversity of the healthy human microbiome publication-title: Nature doi: 10.1038/nature11234 – volume: 109 start-page: 21528 year: 2012 ident: ref48 article-title: Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1215849110 – volume: 11 start-page: 615 year: 2013 ident: ref5 article-title: Gut homeostasis in a microbial world: insights from Drosophila melanogaster publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro3074 – volume: 26 start-page: 266 year: 2010 ident: ref32 article-title: PyNAST: a flexible tool for aligning sequences to a template alignment publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp636 – volume: 4 start-page: e00860 year: 2013 ident: ref21 article-title: Frequent replenishment sustains the beneficial microbiome of Drosophila melanogaster publication-title: MBio – volume: 13 start-page: 1889 year: 2011 ident: ref10 article-title: Low-diversity bacterial community in the gut of the fruitfly Drosophila melanogaster publication-title: Environ Microbiol doi: 10.1111/j.1462-2920.2011.02511.x – volume: 156 start-page: 109 year: 2014 ident: ref19 article-title: PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan publication-title: Cell doi: 10.1016/j.cell.2013.12.018 – year: 2014 ident: ref29 – volume: 101 start-page: 7663 year: 2004 ident: ref47 article-title: Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0307605101 – volume: 317 start-page: 1087 year: 2007 ident: ref26 article-title: CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo publication-title: Science doi: 10.1126/science.1145339 – volume: 1 start-page: a000224 year: 2009 ident: ref22 article-title: Control of NF-kappaB-dependent transcriptional responses by chromatin organization publication-title: Cold Spring Harbor perspectives in biology doi: 10.1101/cshperspect.a000224 – volume: 5 start-page: e01117 year: 2014 ident: ref20 article-title: Microbiota-induced changes in drosophila melanogaster host gene expression and gut morphology publication-title: MBio doi: 10.1128/mBio.01117-14 – volume: 24 start-page: 17 year: 2012 ident: ref4 article-title: Gut-microbiota interactions in non-mammals: what can we learn from Drosophila? publication-title: Semin Immunol doi: 10.1016/j.smim.2011.11.003 – volume: 5 start-page: e9490 year: 2010 ident: ref33 article-title: FastTree 2—approximately maximum-likelihood trees for large alignments publication-title: PLoS ONE doi: 10.1371/journal.pone.0009490 – volume: 14 start-page: 403 year: 2011 ident: ref39 article-title: Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing publication-title: Cell Metab doi: 10.1016/j.cmet.2011.07.012 – volume: 33 start-page: 2349 year: 2014 ident: ref23 article-title: Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling publication-title: EMBO J doi: 10.15252/embj.201488456 – volume: 75 start-page: 1565 year: 2007 ident: ref8 article-title: Native microbial colonization of Drosophila melanogaster and its use as a model of Enterococcus faecalis pathogenesis publication-title: Infection and Immunity doi: 10.1128/IAI.01496-06 – volume: 17 start-page: 72 year: 2015 ident: ref16 article-title: Diet dominates host genotype in shaping the murine gut microbiota publication-title: Cell Host Microbe doi: 10.1016/j.chom.2014.11.010 – volume: 107 start-page: 20051 year: 2010 ident: ref38 article-title: Commensal bacteria play a role in mating preference of Drosophila melanogaster publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1009906107 – volume: 7 start-page: 335 year: 2010 ident: ref28 article-title: QIIME allows analysis of high-throughput community sequencing data publication-title: Nat Methods doi: 10.1038/nmeth.f.303 – volume: 7 start-page: e1002272 year: 2011 ident: ref11 article-title: Bacterial communities of diverse Drosophila species: ecological context of a host-microbe model system publication-title: PLoS Genet doi: 10.1371/journal.pgen.1002272 – volume: 23 start-page: 2333 year: 2009 ident: ref18 article-title: Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila publication-title: Genes Dev doi: 10.1101/gad.1827009 – volume: 186 start-page: 5721 year: 2004 ident: ref37 article-title: Identification of Lactobacillus plantarum genes that are induced in the gastrointestinal tract of mice publication-title: J Bacteriol doi: 10.1128/JB.186.17.5721-5729.2004 – volume: 58 start-page: 2180 year: 2008 ident: ref36 article-title: Acetobacter fabarum sp. nov., an acetic acid bacterium from a Ghanaian cocoa bean heap fermentation publication-title: Int J Syst Evol Microbiol doi: 10.1099/ijs.0.65778-0 – volume: 12 start-page: 1656 year: 2015 ident: ref42 article-title: Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality publication-title: Cell Rep doi: 10.1016/j.celrep.2015.08.004 – ident: ref35 – volume: 6 start-page: 776 year: 2008 ident: ref15 article-title: Worlds within worlds: evolution of the vertebrate gut microbiota publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro1978
SSID	ssj0053866
Score	2.2558665
Snippet	The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific...
SourceID	plos doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e0153476
SubjectTerms	Acetobacteraceae - physiology Age Aging Analysis Animals Bacteria Bioinformatics Biology and Life Sciences Chromatin Chromatin - genetics Chromatin - physiology Chromatin Assembly and Disassembly - genetics Chromatin remodeling Comparative analysis Deletion mutant Dietary supplements Digestive system Digestive tract DNA-Binding Proteins - genetics Drosophila Drosophila melanogaster Drosophila melanogaster - genetics Drosophila melanogaster - physiology Drosophila Proteins - genetics Ecology and Environmental Sciences Flies Gastrointestinal Microbiome - physiology Gastrointestinal tract Gene deletion Gene expression Gene sequencing Genetic factors Homeostasis Infections Insects Intestinal microflora Intestine Lactobacillus plantarum Lactobacillus plantarum - physiology Medicine and Health Sciences Microbiomes Microbiota Microbiota (Symbiotic organisms) Microbiota - physiology Microorganisms Molecular biology Mutants Next-generation sequencing Physiology Regulatory mechanisms (biology) Research and Analysis Methods RNA, Ribosomal, 16S - genetics rRNA 16S Taxa Transcription Factors - genetics
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEF6hqAcuiPJqSoEFIQEHt7Z3vfYeS0toDxRUHurN2pdDpNSO4qS_n5n1xopRpXLgmp3dJPPYmdHOfEPI2wrSLWl0HPHUVhE33EUq4YiMmFmIRhyE4NwPm8gvLoqrK_lta9QX1oR18MAd447iVOnM8iRxQnGt00IYODXWuuJCJV3nVpzLTTLV3cFgxUKERjmWJ0dBLoeLpnaH4AAZR4yRLUfk8fr7W3m0mDftbSHn35WTW65o8pA8CDEkPe5--y655-pHZDdYaUvfByjpD4_J9Nw3QdKmohDoUUTCxQi1ppfOj8ABv0UnfuIOPTk7TWhT08_rFf0y6-CZrmEL3BehrgtPOV36uQezuaLXbq7qZqoQaeEJ-Tn59OPkLAqjFSIjZLqK8hjcfGZUJRwzOKvX2swKWcTKCZ1qYXJmlbQMspM8FgUvrGTCOGOFYg4iKPaUjGpg5h6hBUhUx7aCyMpBtlUUJsfHzFRV2kiQ1piwDZ9LE3DHcfzFvPSPaTnkHx3bSpROGaQzJlG_a9HhbtxB_xFF2NMiarb_AHSpDLpU3qVLY_IKFaDsWlB72y-PeYbAiJLxMXnjKRA5o8bSnKlat215_vXXPxB9vxwQvQtEVQPsMCq0Q8B_QkSuAeXBgBLs3wyW91BdN1xpywSDPjQBCTs3Knz78ut-GQ_FcrvaNWtPwxi-8AJfn3Ua33MWFAK-lQGz8oEtDFg_XKlnvz1wOS-YyJnc_x-yek7uQ-wq8GEvkQdktFqu3QuyY25Ws3b50t8GfwDnAmU0 priority: 102 providerName: Directory of Open Access Journals – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELeg8MALY3xsZQMMQgIeMpLYdeLHsVE2CcY0PrQ3y7GdUqlLqqbl7-fOcQOZNgGv8Tlxznfn38n27wh5WUK6JU0RRzy1ZcQNd5FOODIjjiygEQcQnPtiE9nJSX5-Lk9_J4qXdvBZlrwNOt2b15Xbg8WL8UzcJLdSJgQmW-PTj-vIC74rRLged13P3vLjWfq7WDyYz-rmKqB5-bzkHwvQeON_h36P3A1Qk-63trFJbrjqPtkMztzQ14Fx-s0DMjn2dyVpXVLAgxQJcxHIVvTM-Uo5sLzRsS_MQw-ODhNaV_TDakk_TVsWpwvoAmElHP_CtxwufHmE6UzTCzfTVT3RSMjwkHwbv_96cBSFCgyRETJdRlkMaGBkdCkcM1jS19qRFTKPtRNFWgiTMaulZZDEZLHIeW4lE8YZKzRzALTYIzKo4Oe3Cc1h4ovYlgDAHCRleW4y3PNMdVkYmQszJGw9McoEenKskjFTfs8tgzSlVZtCbaqgzSGJul7zlp7jL_LvcM47WSTX9g9g2lTwVRWnuhhZniROaF4UKYwODDkuipILDSFsSJ6hxaj2pmoXItQ-HyF_omR8SF54CSTYqPAEz0SvmkYdf_7-D0JfznpCr4JQWYM6jA63JuCfkLirJ7nbk4QwYXrN22jfa600KkFsiD4joefa5q9uft4140vxVF7l6pWXYQw3gkGvW62LdJoFg4CvMlBW1nOenur7LdX0h-c35zkTGZOPrx_xDrkDwFXgrl4id8lguVi5J-S2-bmcNounPij8Ai3vYQs priority: 102 providerName: Public Library of Science
Title	Impact of the Chromatin Remodeling Factor CHD1 on Gut Microbiome Composition of Drosophila melanogaster
URI	https://www.ncbi.nlm.nih.gov/pubmed/27093431 https://www.proquest.com/docview/1782205389 https://www.proquest.com/docview/1783340786 https://pubmed.ncbi.nlm.nih.gov/PMC4836739 https://doaj.org/article/02ab5d411e6a4bb286c2df0bbf46a101 http://dx.doi.org/10.1371/journal.pone.0153476
Volume	11
WOSCitedRecordID	wos000374541200022&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agriculture Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Public Health Database (NC LIVE) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELeg44EXYHytMIpBSMBDuiR2neQJrd3KqtERdTAVXiLHcUqlLilNy9_PneuWBU2AxMs91Oc0OZ_PP3_9jpBXOUy3IpW6Dvez3OGKa0d6HJkROxmgEQ0QnJtkE8HZWTgeR7FdcKvsscpNTDSBOisVrpEfeDiUgceE0bv5dwezRuHuqk2hcZPseIiNwZ-D0cUmEoOyEPa6HAu8A9s67XlZ6DYMg4wj08iV4ciw9m9jc2M-K6vrgOfv5yevDEj9u__7KffIHQtF6eHad3bJDV3cJ7u2s1f0jWWkfvuATAbmLiUtcwp4kSKhLgLdgo60yaQDwx_tm8Q9tHdy5NGyoO9XSzqcrlmeLqEKhB17PAyfcrQw6ROmM0kv9UwW5UQiYcND8rl__Kl34tgMDY4Skb90AhfQQkfJXGimMOVvlnUyEYWu1CL1U6EClskoYzDJCVwR8jCLmFBaZUIyDUCMPSKNAlpjj9AQHCN1sxwAmoZJWxiqAPdEfZmnKgqFahK2aahEWfpyzKIxS8yeXADTmLXZEmzexDZvkzjbWvM1fcdf9LvoA1tdJN82P5SLSWL7cuL6Mu1k3PO0kDxNfXg7cHQ3TXMuJIS4JnmOHpSsb7JuQ0hyyDvIrxgx3iQvjQYScBR4wmciV1WVDD5e_IPS-aim9Noq5SWYQ0l7qwK-CYm9apr7NU0II6pWvIf-vrFKlfzyUqi58ePri19si_GheGqv0OXK6DCGG8Vg18frLrO1LDgE_CsDYwW1zlQzfb2kmH4z_Oc8ZCJg0ZM_v9ZTchvArcCdPy_aJ43lYqWfkVvqx3JaLVomUKAcB0aGIMOe1yI73eOzeNQyazMg-_EHkKfdNsihe4oyiI08Bxl3vkKNeDCMv_wEa3J_cA
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwELdGQYIXYHytMJhBIOAhWxI7TvKA0FgprbaVaQw08RIcxymVuqQ0LYh_ir-RO-eDBU3Ayx54rc-uc7kv586_I-RxCsetUMW2xd0ktbji2pIOR2REL4FoREMIzk2zCX80Co6Pw4MV8qO-C4NllbVNNIY6yRV-I99y0JWBxAThy9kXC7tGYXa1bqFRisWu_v4NjmzFi2EP3u8T1-2_PtoZWFVXAUuJ0F1Yvg0ezlMyFZopbFObJF4iwsCWWsRuLJTPEhkmDAJz3xYBD5KQCaVVIiTTEDwwWPcCuci5a6MWHXgfa8sPmxOiup7HfGerkobNWZ7pTXC7jCOyySn3Z7oENL6gM5vmxVmB7u_1mqccYP_a_8a66-RqFWrT7VI3VsmKzm6Q1cqYFfRZhbj9_CYZD81dUZqnFOJhioDBGMhn9FCbTkHg3mnfNCaiO4OeQ_OMvlku6P6kRLE6gSlgVqvyN1ylNzftISZTSU_0VGb5WCIgxS3y_lwe-DbpZPD21wgNQPBjO0khANVwKA0C5WPO15VprMJAqC5htWBEqoJnxy4h08jkHH04ppVsi1CcokqcusRqZs1KeJK_0L9CmWtoEVzc_JDPx1FlqyLblbGXcMfRQvI4dmF3oMh2HKdcSDDhXbKBEhuVN3UbExltcw_xI0PGu-SRoUCAkQwrmMZyWRTR8O2HfyB6d9gieloRpTmwQ8nq1gg8EwKXtSjXW5RgJlVreA31q-ZKEf3SCphZ683Zww-bYVwUqxIznS8NDWOYCAe-3ilVtOEsCAT8KwNm-S3lbbG-PZJNPht8dx4w4bPw7p-3tUEuD47296K94Wj3HrkCgbzALKcTrpPOYr7U98kl9XUxKeYPjJGi5NN5q_ZPLOjPFw
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3Nb9MwFLdGQYgLML5WGMwgEHDImsSukxwQGitl1aBUG6CJS3Acp1TqktK0IP41_jrec5yyoAm47MC1fnaT19_7cP38e4Q8zGC7FanEdbifZg5XXDvS48iM2E0hG9GQgnPTbCIYDsOjo2i0Rn7Ud2GwrLL2icZRp4XC_8g7HoYyQEwYdTJbFjHq9Z_PvjjYQQpPWut2GhVE9vX3b7B9K58NevBbP_L9_st3u3uO7TDgKBH5CydwIdp1lcyEZgpb1qZpNxVR6EotEj8RKmCpjFIGSXrgipCHacSE0ioVkmlIJBise46cD2CPieWEo-7HOgrAgwphr-qxwOtYZGzPilxvQwhmHFlOToRC0zFgFRdas2lRnpb0_l67eSIY9q_8z2q8Si7bFJzuVDazTtZ0fo2sWydX0ieWifvpdTIemDuktMgo5MkUiYQxwc_pgTYdhCDs075pWER393oeLXL6armgbyYVu9UxTAF3a8vicJXe3LSNmEwlPdZTmRdjiUQVN8j7M3nhm6SVAxI2CA3BIBI3zSAx1bBZDUMV4FmwL7NERaFQbcJqkMTK0rZj95BpbM4iA9i-VWqLEVqxhVabOKtZs4q25C_yLxB_K1kkHTcfFPNxbH1Y7Poy6abc87SQPEl8eDowcDdJMi4kuPY22UL0xtUN3pXrjHd4F3klI8bb5IGRQOKRHLE3lsuyjAdvP_yD0OFBQ-ixFcoKUIeS9jYJvBMSmjUkNxuS4D5VY3gDba3WShn_shCYWdvQ6cP3V8O4KFYr5rpYGhnG8IAc9HqrMteVZgEQ8K0MlBU0DLmh-uZIPvlseN95yETAott_fqwtchEsOn49GO7fIZcgvxd4-OlFm6S1mC_1XXJBfV1Myvk9468o-XTWlv0TDnnX4Q
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Impact+of+the+Chromatin+Remodeling+Factor+CHD1+on+Gut+Microbiome+Composition+of+Drosophila+melanogaster&rft.jtitle=PloS+one&rft.au=Schoberleitner%2C+Ines&rft.au=Krogsdam%2C+Anne&rft.au=Sebald%2C+Johanna&rft.au=Orth-H%C3%B6ller%2C+Dorothea&rft.date=2016-04-19&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=11&rft.issue=4&rft_id=info:doi/10.1371%2Fjournal.pone.0153476&rft.externalDBID=n%2Fa&rft.externalDocID=A453447934
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon