Differentiating axonal loss and demyelination in chronic MS lesions: A novel approach using single streamline diffusivity analysis

We describe a new single-streamline based approach to analyse diffusivity within chronic MS lesions. We used the proposed method to examine diffusivity profiles in 30 patients with relapsing multiple sclerosis and observed a significant increase of both RD and AD within the lesion core (0.38+/-0.09...

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Bibliographic Details
Published in:	PloS one Vol. 16; no. 1; p. e0244766
Main Authors:	Klistorner, Samuel, Barnett, Michael H., Wasserthal, Jakob, Yiannikas, Con, Barton, Joshua, Parratt, John, You, Yuyi, Graham, Stuart L., Klistorner, Alexander
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 06.01.2021 Public Library of Science (PLoS)
Subjects:	Adult Alzheimer's disease Axons - metabolism Axons - pathology Biology and Life Sciences Brain research Care and treatment Chronic Disease Clinical trials Degeneration Demyelination Development and progression Diffusion Magnetic Resonance Imaging Diffusivity Female Health sciences Humans Lesions Male Medical research Medicine and Health Sciences Methods Middle Aged Multiple sclerosis Multiple Sclerosis - pathology Nerve Fibers, Myelinated - pathology Nervous system Neuroprotection Recurrence Research and Analysis Methods Scleroderma White Matter - diagnostic imaging White Matter - pathology Australia Sydney New South Wales Australia New South Wales Australia
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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