Chronic Medical Conditions and Risk of Sepsis

We sought to determine the associations between baseline chronic medical conditions and future risk of sepsis. Longitudinal cohort study using the 30,239 community-dwelling participants of the REGARDS cohort. We determined associations between baseline chronic medical conditions and incident sepsis...

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Veröffentlicht in:PloS one Jg. 7; H. 10; S. e48307
Hauptverfasser: Wang, Henry E., Shapiro, Nathan I., Griffin, Russell, Safford, Monika M., Judd, Suzanne, Howard, George
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 31.10.2012
Public Library of Science (PLoS)
Schlagworte:
Aged
Alcohol
Alcoholic beverages
Atrial fibrillation
Cardiac arrhythmia
Cardiovascular disease
Cerebral infarction
Chronic Disease - epidemiology
Chronic kidney failure
Cohort Studies
Coronary artery
Coronary artery disease
Coronary heart disease
Diabetes
Diabetes mellitus
Disease prevention
Dyslipidemia
Emergency medical care
Epidemiology
Female
Fibrillation
Health aspects
Health Behavior
Health care
Heart diseases
Hospitalization
Hospitalization - statistics & numerical data
Hospitals
Humans
Hypertension
Infarction
Infection
Infections
Inflammation
Inflammatory response
Intensive care
Kidney transplantation
Laboratories
Lung diseases
Male
Medical records
Medicine
Metabolic disorders
Middle Aged
Mortality
Myocardial infarction
Pneumonia
Population
Preventive medicine
Public health
Racial differences
Risk
Risk factors
Sepsis
Sepsis - complications
Sepsis - epidemiology
Sepsis - therapy
Smoking
Stroke
Systemic inflammatory response syndrome
Thromboembolism
Thrombosis
Tobacco
Urinary tract infections
Vascular diseases
Vital signs
Alabama
United States > US
ISSN:1932-6203, 1932-6203
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Zusammenfassung:We sought to determine the associations between baseline chronic medical conditions and future risk of sepsis. Longitudinal cohort study using the 30,239 community-dwelling participants of the REGARDS cohort. We determined associations between baseline chronic medical conditions and incident sepsis episodes, defined as hospitalization for an infection with the presence of infection plus two or more systemic inflammatory response syndrome criteria. Over the mean observation time of 4.6 years (February 5, 2003 through October 14, 2011), there were 975 incident cases of sepsis. Incident sepsis episodes were associated with older age (p<0.001), white race (HR 1.39; 95% CI: 1.22-1.59), lower education (p<0.001) and income (p<0.001), tobacco use (p<0.001), and alcohol use (p = 0.02). Incident sepsis episodes were associated with baseline chronic lung disease (adjusted HR 2.43; 95% CI: 2.05-2.86), peripheral artery disease (2.16; 1.58-2.95), chronic kidney disease (1.99; 1.73-2.29), myocardial infarction 1.79 (1.49-2.15), diabetes 1.78 (1.53-2.07), stroke 1.67 (1.34-2.07), deep vein thrombosis 1.63 (1.29-2.06), coronary artery disease 1.61 (1.38-1.87), hypertension 1.49 (1.29-1.74), atrial fibrillation 1.48 (1.21-1.81) and dyslipidemia 1.16 (1.01-1.34). Sepsis risk increased with the number of chronic medical conditions (p<0.001). Individuals with chronic medical conditions are at increased risk of future sepsis events.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Conceived and designed the experiments: HEW NIS MMS GH. Wrote the paper: HEW. Coordinated data collection: HEW MMS. Performed the analysis: RG. Contributed to the critical review of results: HEW NIS RG MMS SJ GH. Critically reviewed and approved the manuscript: HEW NIS RG MMS SJ GH. Takes responsibility for the paper as a whole: HEW.
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0048307