Effect of Natalizumab Treatment on Circulating Plasmacytoid Dendritic Cells: A Cross-Sectional Observational Study in Patients with Multiple Sclerosis

Dendritic cells (DCs) serve a critical role both in promoting and inhibiting adaptive immunity. The goal of this study was to investigate the effect of natalizumab (NTZ) treatment on DC numbers, phenotype, and function in patients with multiple sclerosis (MS). Frequency and phenotype of myeloid and...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 7; p. e103716
Main Authors:	Kivisäkk, Pia, Francois, Katiana, Mbianda, Julvet, Gandhi, Roopali, Weiner, Howard L., Khoury, Samia J.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 30.07.2014 Public Library of Science (PLoS)
Subjects:	Adaptive immunity Adult Aged Analysis Antibodies, Monoclonal, Humanized - pharmacology Antibodies, Monoclonal, Humanized - therapeutic use B cells Biological response modifiers Biology and Life Sciences Blood Care and treatment CCR7 protein CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - physiology Cell activation Cell differentiation Cell Differentiation - drug effects Cells, Cultured CpG islands Cross-Sectional Studies Cytokines Dendritic cells Dendritic Cells - drug effects Dendritic Cells - physiology Differentiation (biology) Female Gene Expression Genotype & phenotype Histocompatibility antigen HLA Homology Hospitals Humans Immunity Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Immunotherapy Integrins Interferon Interleukin 12 Interleukin 6 Lymphatic system Lymphocytes Lymphocytes T Male Medical research Medical schools Middle Aged Monoclonal antibodies Multiple sclerosis Multiple Sclerosis - blood Multiple Sclerosis - drug therapy Multiple Sclerosis - immunology Natalizumab Observational studies Oligonucleotides Patients Peripheral blood Peripheral circulation Phenotypes Research and Analysis Methods Rodents Studies T cell receptors T cells TLR9 protein Toll-like receptors Young Adult United States > US Massachusetts
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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