Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical Coherence Tomography

To investigate the profile and determinants of retinal optical intensity in normal subjects using 3D spectral domain optical coherence tomography (SD OCT). A total of 231 eyes from 231 healthy subjects ranging in age from 18 to 80 years were included and underwent a 3D OCT scan. Forty-four eyes were...

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Vydané v:	PloS one Ročník 11; číslo 2; s. e0148183
Hlavní autori:	Chen, Binyao, Gao, Enting, Chen, Haoyu, Yang, Jianling, Shi, Fei, Zheng, Ce, Zhu, Weifang, Xiang, Dehui, Chen, Xinjian, Zhang, Mingzhi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 10.02.2016 Public Library of Science (PLoS)
Predmet:	Adolescent Adult Age Age factors Aged Aged, 80 and over Algorithms Biology and Life Sciences Care and treatment China Coherence Correlation analysis Correlation coefficient Correlation coefficients Determinants Diabetes Diabetes mellitus Diabetic retinopathy Diabetic Retinopathy - prevention & control Diagnosis Disease Engineering Epithelium Eye (anatomy) Family medical history Female Glaucoma Humans Image Processing, Computer-Assisted Image quality Investigations Male Medical imaging Medicine and Health Sciences Middle Aged Morphology Multivariate Analysis Observer Variation Optic nerve Optical Coherence Tomography Optical tomography Optics People and Places Photoreceptors Regression Analysis Reproducibility Reproducibility of Results Research and Analysis Methods Retina Retina - pathology Retina - physiology Retinal pigment epithelium Retinopathy Science Sex Social Sciences Software Spectrophotometry Tomography Tomography, Optical Coherence Young Adult China
ISSN:	1932-6203, 1932-6203
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Popis
Shrnutí:	To investigate the profile and determinants of retinal optical intensity in normal subjects using 3D spectral domain optical coherence tomography (SD OCT). A total of 231 eyes from 231 healthy subjects ranging in age from 18 to 80 years were included and underwent a 3D OCT scan. Forty-four eyes were randomly chosen to be scanned by two operators for reproducibility analysis. Distribution of optical intensity of each layer and regions specified by the Early Treatment of Diabetic Retinopathy Study (ETDRS) were investigated by analyzing the OCT raw data with our automatic graph-based algorithm. Univariate and multivariate analyses were performed between retinal optical intensity and sex, age, height, weight, spherical equivalent (SE), axial length, image quality, disc area and rim/disc area ratio (R/D area ratio). For optical intensity measurements, the intraclass correlation coefficient of each layer ranged from 0.815 to 0.941, indicating good reproducibility. Optical intensity was lowest in the central area of retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer and photoreceptor layer, except for the retinal pigment epithelium (RPE). Optical intensity was positively correlated with image quality in all retinal layers (0.553<β<0.851, p<0.01), and negatively correlated with age in most retinal layers (-0.362<β<-0.179, p<0.01), except for the RPE (β = 0.456, p<0.01), outer nuclear layer and photoreceptor layer (p>0.05). There was no relationship between retinal optical intensity and sex, height, weight, SE, axial length, disc area and R/D area ratio. There was a specific pattern of distribution of retinal optical intensity in different regions. The optical intensity was affected by image quality and age. Image quality can be used as a reference for normalization. The effect of age needs to be taken into consideration when using OCT for diagnosis.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. These authors also contributed equally to this work. Conceived and designed the experiments: MZ HC CZ XC. Performed the experiments: BC JY EG. Analyzed the data: BC EG JY CZ. Contributed reagents/materials/analysis tools: EG FS WZ DX XC. Wrote the paper: BC HC MZ. Revised the manuscript: BC MZ CZ HC EG XC.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0148183