Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer

KLK9, 10, 11, and 15 may represent potential cancer biomarkers for evaluating ovarian cancer prognosis. In the present study, we selected a homogeneous cohort including 139 patients of advanced high-grade serous ovarian cancer (FIGO stage III/IV) and assessed the mRNA levels of KLK9, 10, 11, and 15...

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Veröffentlicht in:PloS one Jg. 12; H. 11; S. e0186847
Hauptverfasser: Geng, Xiaocong, Liu, Yueyang, Diersch, Sandra, Kotzsch, Matthias, Grill, Sabine, Weichert, Wilko, Kiechle, Marion, Magdolen, Viktor, Dorn, Julia
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 02.11.2017
Public Library of Science (PLoS)
Schlagworte:
Ascitic fluid
Bioindicators
Biology and Life Sciences
Biomarkers
Breast cancer
Cancer
Colon
Disease Progression
Female
Gene expression
Genetic aspects
Gynecology
Humans
Kallikrein
Kallikreins - genetics
Medical prognosis
Medicine and Health Sciences
Messenger RNA
Obstetrics
Ovarian cancer
Ovarian carcinoma
Ovarian Neoplasms - enzymology
Ovarian Neoplasms - pathology
Patients
Peptidase
Peptidases
Polymerase chain reaction
Prognosis
Quality
Real-Time Polymerase Chain Reaction
Regression analysis
RNA, Messenger - genetics
Studies
Survival
Survival Rate
Thyroid gland
Tumors
ISSN:1932-6203, 1932-6203
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Zusammenfassung:KLK9, 10, 11, and 15 may represent potential cancer biomarkers for evaluating ovarian cancer prognosis. In the present study, we selected a homogeneous cohort including 139 patients of advanced high-grade serous ovarian cancer (FIGO stage III/IV) and assessed the mRNA levels of KLK9, 10, 11, and 15 in tumor tissue by quantitative PCR. No significant associations of KLK9, 10, 11, and 15 mRNA with established clinical parameters (residual tumor mass, ascitic fluid volume) were found. Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases. In univariate Cox regression analysis, elevated KLK11 mRNA levels were significantly linked with prolonged overall survival (OS; p = 0.021) and progression-free survival (PFS; p = 0.008). KLK15 mRNA levels showed a trend towards significance in case of OS (p = 0.06); KLK9 and KLK10 mRNA expression levels were not associated with patients' outcome. In multivariable Cox analysis, KLK11 mRNA expression levels, apart from residual tumor mass, remained an independent predictive marker for OS (p = 0.007) and PFS (p = 0.015). Here, elevated KLK15 mRNA expression levels turned out to be significantly related to prolonged OS (p = 0.025) as well. High KLK11 but not the other KLK mRNA levels can be considered as strong independent favorable prognostic factor in this major ovarian cancer subtype.
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Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0186847