Natural killer cell phenotype is altered in HIV-exposed seronegative women
Highly exposed seronegative (HESN) individuals present a unique setting to study mechanisms of protection against HIV acquisition. As natural killer (NK) cell activation and function have been implicated as a correlate of protection in HESN individuals, we sought to better understand the features of...
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| Veröffentlicht in: | PloS one Jg. 15; H. 9; S. e0238347 |
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| Sprache: | Englisch |
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01.09.2020
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| Abstract | Highly exposed seronegative (HESN) individuals present a unique setting to study mechanisms of protection against HIV acquisition. As natural killer (NK) cell activation and function have been implicated as a correlate of protection in HESN individuals, we sought to better understand the features of NK cells that may confer protection. We used mass cytometry to phenotypically profile NK cells from a cohort of Beninese sex workers and healthy controls. We found that NK cells from HESN women had increased expression of NKG2A, NKp30 and LILRB1, as well as the Fc receptor CD16, and decreased expression of DNAM-1, CD94, Siglec-7, and NKp44. Using functional assessments of NK cells from healthy donors against autologous HIV-infected CD4+ T cells, we observed that NKp30+ and Siglec-7+ cells had improved functional activity. Further, we found that NK cells from HESN women trended towards increased antibody-dependent cellular cytotoxicity (ADCC) activity; this activity correlated with increased CD16 expression. Overall, we identify features of NK cells in HESN women that may contribute to protection from HIV infection. Follow up studies with larger cohorts are warranted to confirm these findings. |
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| AbstractList | Highly exposed seronegative (HESN) individuals present a unique setting to study mechanisms of protection against HIV acquisition. As natural killer (NK) cell activation and function have been implicated as a correlate of protection in HESN individuals, we sought to better understand the features of NK cells that may confer protection. We used mass cytometry to phenotypically profile NK cells from a cohort of Beninese sex workers and healthy controls. We found that NK cells from HESN women had increased expression of NKG2A, NKp30 and LILRB1, as well as the Fc receptor CD16, and decreased expression of DNAM-1, CD94, Siglec-7, and NKp44. Using functional assessments of NK cells from healthy donors against autologous HIV-infected CD4+ T cells, we observed that NKp30+ and Siglec-7+ cells had improved functional activity. Further, we found that NK cells from HESN women trended towards increased antibody-dependent cellular cytotoxicity (ADCC) activity; this activity correlated with increased CD16 expression. Overall, we identify features of NK cells in HESN women that may contribute to protection from HIV infection. Follow up studies with larger cohorts are warranted to confirm these findings.Highly exposed seronegative (HESN) individuals present a unique setting to study mechanisms of protection against HIV acquisition. As natural killer (NK) cell activation and function have been implicated as a correlate of protection in HESN individuals, we sought to better understand the features of NK cells that may confer protection. We used mass cytometry to phenotypically profile NK cells from a cohort of Beninese sex workers and healthy controls. We found that NK cells from HESN women had increased expression of NKG2A, NKp30 and LILRB1, as well as the Fc receptor CD16, and decreased expression of DNAM-1, CD94, Siglec-7, and NKp44. Using functional assessments of NK cells from healthy donors against autologous HIV-infected CD4+ T cells, we observed that NKp30+ and Siglec-7+ cells had improved functional activity. Further, we found that NK cells from HESN women trended towards increased antibody-dependent cellular cytotoxicity (ADCC) activity; this activity correlated with increased CD16 expression. Overall, we identify features of NK cells in HESN women that may contribute to protection from HIV infection. Follow up studies with larger cohorts are warranted to confirm these findings. Highly exposed seronegative (HESN) individuals present a unique setting to study mechanisms of protection against HIV acquisition. As natural killer (NK) cell activation and function have been implicated as a correlate of protection in HESN individuals, we sought to better understand the features of NK cells that may confer protection. We used mass cytometry to phenotypically profile NK cells from a cohort of Beninese sex workers and healthy controls. We found that NK cells from HESN women had increased expression of NKG2A, NKp30 and LILRB1, as well as the Fc receptor CD16, and decreased expression of DNAM-1, CD94, Siglec-7, and NKp44. Using functional assessments of NK cells from healthy donors against autologous HIV-infected CD4+ T cells, we observed that NKp30+ and Siglec-7+ cells had improved functional activity. Further, we found that NK cells from HESN women trended towards increased antibody-dependent cellular cytotoxicity (ADCC) activity; this activity correlated with increased CD16 expression. Overall, we identify features of NK cells in HESN women that may contribute to protection from HIV infection. Follow up studies with larger cohorts are warranted to confirm these findings. Highly exposed seronegative (HESN) individuals present a unique setting to study mechanisms of protection against HIV acquisition. As natural killer (NK) cell activation and function have been implicated as a correlate of protection in HESN individuals, we sought to better understand the features of NK cells that may confer protection. We used mass cytometry to phenotypically profile NK cells from a cohort of Beninese sex workers and healthy controls. We found that NK cells from HESN women had increased expression of NKG2A, NKp30 and LILRB1, as well as the Fc receptor CD16, and decreased expression of DNAM-1, CD94, Siglec-7, and NKp44. Using functional assessments of NK cells from healthy donors against autologous HIV-infected CD4.sup.+ T cells, we observed that NKp30.sup.+ and Siglec-7.sup.+ cells had improved functional activity. Further, we found that NK cells from HESN women trended towards increased antibody-dependent cellular cytotoxicity (ADCC) activity; this activity correlated with increased CD16 expression. Overall, we identify features of NK cells in HESN women that may contribute to protection from HIV infection. Follow up studies with larger cohorts are warranted to confirm these findings. |
| Audience | Academic |
| Author | Ferreira, Anne-Maud Labbé, Annie-Claude Vendrame, Elena Seiler, Christof Alary, Michel Holmes, Susan Ranganath, Thanmayi Blish, Catherine A. Poudrier, Johanne Zhao, Nancy Q. Guédou, Fernand Roger, Michel |
| AuthorAffiliation | 5 Département de Microbiologie, Infectiologie et Immunologie de l‘Université de Montréal, Montréal, Canada, Service de maladies infectieuses et microbiologie, Hôpital Maisonneuve-Rosemont, Montréal, Canada 1 Department of Medicine, Division of Infection Diseases and Geographic Medicine, Stanford University, Stanford, CA, United States of America 8 Chan Zuckerberg Biohub, San Francisco, CA, United States of America 2 Immunology Program, Stanford University, Stanford, CA, United States of America 6 Dispensaire IST, Cotonou, Bénin 7 Laboratoire d’Immunogénétique, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montréal, Canada, Département de Microbiologie, Infectiologie et Immunologie de l‘Université de Montréal, Montréal, Canada 3 Department of Statistics, Stanford University, Stanford, CA, United States of America Emory University School of Medicine, UNITED STATES 4 Centre de Recherche du CHU de Québec–Université Laval, Québec, Canada, Département de Médecine So |
| AuthorAffiliation_xml | – name: Emory University School of Medicine, UNITED STATES – name: 7 Laboratoire d’Immunogénétique, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montréal, Canada, Département de Microbiologie, Infectiologie et Immunologie de l‘Université de Montréal, Montréal, Canada – name: 1 Department of Medicine, Division of Infection Diseases and Geographic Medicine, Stanford University, Stanford, CA, United States of America – name: 4 Centre de Recherche du CHU de Québec–Université Laval, Québec, Canada, Département de Médecine Sociale et Préventive, Université Laval, Québec, Canada, Institut National de Santé Publique du Québec, Québec, Canada – name: 5 Département de Microbiologie, Infectiologie et Immunologie de l‘Université de Montréal, Montréal, Canada, Service de maladies infectieuses et microbiologie, Hôpital Maisonneuve-Rosemont, Montréal, Canada – name: 3 Department of Statistics, Stanford University, Stanford, CA, United States of America – name: 2 Immunology Program, Stanford University, Stanford, CA, United States of America – name: 6 Dispensaire IST, Cotonou, Bénin – name: 8 Chan Zuckerberg Biohub, San Francisco, CA, United States of America |
| Author_xml | – sequence: 1 givenname: Nancy Q. surname: Zhao fullname: Zhao, Nancy Q. – sequence: 2 givenname: Elena orcidid: 0000-0002-5595-1773 surname: Vendrame fullname: Vendrame, Elena – sequence: 3 givenname: Anne-Maud surname: Ferreira fullname: Ferreira, Anne-Maud – sequence: 4 givenname: Christof surname: Seiler fullname: Seiler, Christof – sequence: 5 givenname: Thanmayi orcidid: 0000-0001-9865-2119 surname: Ranganath fullname: Ranganath, Thanmayi – sequence: 6 givenname: Michel orcidid: 0000-0002-0246-4429 surname: Alary fullname: Alary, Michel – sequence: 7 givenname: Annie-Claude surname: Labbé fullname: Labbé, Annie-Claude – sequence: 8 givenname: Fernand surname: Guédou fullname: Guédou, Fernand – sequence: 9 givenname: Johanne surname: Poudrier fullname: Poudrier, Johanne – sequence: 10 givenname: Susan surname: Holmes fullname: Holmes, Susan – sequence: 11 givenname: Michel surname: Roger fullname: Roger, Michel – sequence: 12 givenname: Catherine A. surname: Blish fullname: Blish, Catherine A. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32870938$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2020 Public Library of Science 2020 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020 Zhao et al 2020 Zhao et al |
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| Title | Natural killer cell phenotype is altered in HIV-exposed seronegative women |
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