Natural killer cell phenotype is altered in HIV-exposed seronegative women

Highly exposed seronegative (HESN) individuals present a unique setting to study mechanisms of protection against HIV acquisition. As natural killer (NK) cell activation and function have been implicated as a correlate of protection in HESN individuals, we sought to better understand the features of...

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Vydáno v:	PloS one Ročník 15; číslo 9; s. e0238347
Hlavní autoři:	Zhao, Nancy Q., Vendrame, Elena, Ferreira, Anne-Maud, Seiler, Christof, Ranganath, Thanmayi, Alary, Michel, Labbé, Annie-Claude, Guédou, Fernand, Poudrier, Johanne, Holmes, Susan, Roger, Michel, Blish, Catherine A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 01.09.2020 Public Library of Science (PLoS)
Témata:	Adult Antibodies Antibody-Dependent Cell Cytotoxicity - immunology Antigens Antigens, Differentiation, Myelomonocytic - metabolism Biology and life sciences CD16 antigen CD226 antigen CD4 antigen Cell activation Cytometry Cytotoxicity Disease prevention Fc receptors Female Generalized linear models Genotype GPI-Linked Proteins - genetics GPI-Linked Proteins - metabolism Health aspects HIV HIV infections HIV Infections - immunology HIV Infections - pathology Human immunodeficiency virus Humans Immunology Infections Killer cells Killer Cells, Natural - cytology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lectins - metabolism Linear Models Lymphocytes Lymphocytes T Medical examination Medicine Medicine and health sciences Natural Cytotoxicity Triggering Receptor 3 - metabolism Natural killer cells NKG2 antigen Phenotype Phenotypes Receptors, IgG - genetics Receptors, IgG - metabolism Research and Analysis Methods Risk factors Sex oriented businesses Sex Workers Sexually transmitted diseases STD Supervision Toxicity Vaccines Viral infections Women patients Womens health Benin Canada United States > US
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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Shrnutí:	Highly exposed seronegative (HESN) individuals present a unique setting to study mechanisms of protection against HIV acquisition. As natural killer (NK) cell activation and function have been implicated as a correlate of protection in HESN individuals, we sought to better understand the features of NK cells that may confer protection. We used mass cytometry to phenotypically profile NK cells from a cohort of Beninese sex workers and healthy controls. We found that NK cells from HESN women had increased expression of NKG2A, NKp30 and LILRB1, as well as the Fc receptor CD16, and decreased expression of DNAM-1, CD94, Siglec-7, and NKp44. Using functional assessments of NK cells from healthy donors against autologous HIV-infected CD4+ T cells, we observed that NKp30+ and Siglec-7+ cells had improved functional activity. Further, we found that NK cells from HESN women trended towards increased antibody-dependent cellular cytotoxicity (ADCC) activity; this activity correlated with increased CD16 expression. Overall, we identify features of NK cells in HESN women that may contribute to protection from HIV infection. Follow up studies with larger cohorts are warranted to confirm these findings.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0238347