Association of cardiovascular disease and 10 other pre-existing comorbidities with COVID-19 mortality: A systematic review and meta-analysis

Estimating the risk of pre-existing comorbidities on coronavirus disease 2019 (COVID-19) mortality may promote the importance of targeting populations at risk to improve survival. This systematic review and meta-analysis aimed to estimate the association of pre-existing comorbidities with COVID-19 m...

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Veröffentlicht in:	PloS one Jg. 15; H. 8; S. e0238215
Hauptverfasser:	Ssentongo, Paddy, Ssentongo, Anna E., Heilbrunn, Emily S., Ba, Djibril M., Chinchilli, Vernon M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 26.08.2020 Public Library of Science (PLoS)
Schlagworte:	Acquired immune deficiency syndrome Aged AIDS Asthma Bias Biology and Life Sciences Cancer Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - mortality Cerebrovascular diseases Chronic diseases Chronic obstructive pulmonary disease Comorbidity Complications and side effects Congestive heart failure Coronary artery disease Coronavirus Infections - mortality Coronaviruses COVID-19 Diabetes Diabetes mellitus Diabetes Mellitus - mortality Failure analysis Female Health risks Heterogeneity HIV Human immunodeficiency virus Humans Hypertension Kidney diseases Kidneys Liver cancer Liver diseases Lung cancer Lung diseases Male Medicine and Health Sciences Meta-analysis Middle Aged Mortality Mortality risk Neoplasms - mortality Obstructive lung disease Pandemics Patient outcomes People and Places Pneumonia, Viral - mortality Prognosis Renal failure Renal Insufficiency, Chronic - mortality Risk assessment Survival Viral diseases United States United States > US Europe China Pennsylvania
ISSN:	1932-6203, 1932-6203
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Zusammenfassung:	Estimating the risk of pre-existing comorbidities on coronavirus disease 2019 (COVID-19) mortality may promote the importance of targeting populations at risk to improve survival. This systematic review and meta-analysis aimed to estimate the association of pre-existing comorbidities with COVID-19 mortality. We searched MEDLINE, SCOPUS, OVID, and Cochrane Library databases, and medrxiv.org from December 1st, 2019, to July 9th, 2020. The outcome of interest was the risk of COVID-19 mortality in patients with and without pre-existing comorbidities. We analyzed 11 comorbidities: cardiovascular diseases, hypertension, diabetes, congestive heart failure, cerebrovascular disease, chronic kidney disease, chronic liver disease, cancer, chronic obstructive pulmonary disease, asthma, and HIV/AIDS. Two reviewers independently extracted data and assessed the risk of bias. All analyses were performed using random-effects models and heterogeneity was quantified. Eleven pre-existing comorbidities from 25 studies were included in the meta-analysis (n = 65, 484 patients with COVID-19; mean age; 61 years; 57% male). Overall, the between-study heterogeneity was medium, and studies had low publication bias and high quality. Cardiovascular disease (risk ratio (RR) 2.25, 95% CI = 1.60-3.17, number of studies (n) = 14), hypertension (1.82 [1.43 to 2.32], n = 13), diabetes (1.48 [1.02 to 2.15], n = 16), congestive heart failure (2.03 [1.28 to 3.21], n = 3), chronic kidney disease (3.25 [1.13 to 9.28)], n = 9) and cancer (1.47 [1.01 to 2.14), n = 10) were associated with a significantly greater risk of mortality from COVID-19. Patients with COVID-19 with cardiovascular disease, hypertension, diabetes, congestive heart failure, chronic kidney disease and cancer have a greater risk of mortality compared to patients with COVID-19 without these comorbidities. Tailored infection prevention and treatment strategies targeting this high-risk population might improve survival.
Bibliographie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0238215