Cell Migration Is Regulated by AGE-RAGE Interaction in Human Oral Cancer Cells In Vitro

Advanced glycation end products (AGEs) are produced in an irreversible non-enzymatic reaction of carbohydrates and proteins. Patients with diabetes mellitus (DM) are known to have elevated AGE levels, which is viewed as a risk factor of diabetes-related complications. In a clinical setting, it has b...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 10; p. e110542
Main Authors:	Ko, Shun-Yao, Ko, Hshin-An, Shieh, Tzong-Ming, Chang, Weng-Cheng, Chen, Hong-I, Chang, Shu-Shing, Lin, I-Hsuan
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 16.10.2014 Public Library of Science (PLoS)
Subjects:	Adult Advanced glycosylation end products Age Alzheimer's disease Angiogenesis Biology and Life Sciences Cancer Carbohydrates Cell adhesion & migration Cell growth Cell Line, Tumor Cell migration Cell Movement - genetics Cell Proliferation - drug effects Cell Proliferation - genetics Complications Correlation analysis Diabetes Diabetes Complications - genetics Diabetes Complications - pathology Diabetes mellitus Diabetes Mellitus - genetics Diabetes Mellitus - pathology Diabetics Enzymes Experiments Female Flavonoids - administration & dosage Fluorides Gelatinase A Gelatinase B Gene expression Gene Expression Regulation, Neoplastic - drug effects Glycation End Products, Advanced - genetics Glyceraldehyde Glycosylation Health risks Humans Male Malignancy Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis Medicine Melanoma Metastases Metastasis Mouth cancer Mouth Neoplasms - complications Mouth Neoplasms - genetics Mouth Neoplasms - pathology Neoplasm Metastasis Oral cancer Patients Penicillin Phosphorylation Proteins Receptor for Advanced Glycation End Products - antagonists & inhibitors Receptor for Advanced Glycation End Products - genetics Risk factors RNA, Small Interfering RNA-mediated interference Science Survival United States > US Taiwan
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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