Grey and White Matter Magnetisation Transfer Ratio Measurements in the Lumbosacral Enlargement: A Pilot In Vivo Study at 3T

Magnetisation transfer (MT) imaging of the central nervous system has provided further insight into the pathophysiology of neurological disease. However, the use of this method to study the lower spinal cord has been technically challenging, despite the important role of this region, not only for mo...

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Veröffentlicht in:	PloS one Jg. 10; H. 7; S. e0134495
Hauptverfasser:	Ugorji, Chinyere O., Samson, Rebecca S., Liechti, Martina D., Panicker, Jalesh N., Miller, David H., Wheeler-Kingshott, Claudia A. M., Yiannakas, Marios C.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 31.07.2015 Public Library of Science (PLoS)
Schlagworte:	Adult Amyotrophic lateral sclerosis Brain research Central nervous system Coefficient of variation Enlargement Feasibility studies Female Gray Matter - anatomy & histology Healthy Volunteers Humans Image processing Image segmentation In vivo methods and tests Intestine Lumbar Vertebrae - anatomy & histology Magnetic Resonance Imaging Magnetics Magnetization Male Measurement Medical imaging equipment Motor task performance Multiple sclerosis Nervous system diseases Neurology Neurosurgery NMR Nuclear magnetic resonance Pilot Projects Reproducibility Sacrum - anatomy & histology Spinal cord Spinal cord injuries Statistical analysis Substantia alba Substantia grisea Urinary tract White Matter - anatomy & histology
ISSN:	1932-6203, 1932-6203
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Abstract	Magnetisation transfer (MT) imaging of the central nervous system has provided further insight into the pathophysiology of neurological disease. However, the use of this method to study the lower spinal cord has been technically challenging, despite the important role of this region, not only for motor control of the lower limbs, but also for the neural control of lower urinary tract, sexual and bowel functions. In this study, the feasibility of obtaining reliable grey matter (GM) and white matter (WM) magnetisation transfer ratio (MTR) measurements within the lumbosacral enlargement (LSE) was investigated in ten healthy volunteers using a clinical 3T MRI system. The mean cross-sectional area of the LSE (LSE-CSA) and the mean GM area (LSE-GM-CSA) were first obtained by means of image segmentation and tissue-specific (i.e. WM and GM) MTR measurements within the LSE were subsequently obtained. The reproducibility of the segmentation method and MTR measurements was assessed from repeated measurements and their % coefficient of variation (%COV). Mean (± SD) LSE-CSA across 10 healthy subjects was 59.3 (± 8.4) mm2 and LSE-GM-CSA was 17.0 (± 3.1) mm2. The mean intra- and inter-rater % COV for measuring the LSE-CSA were 0.8% and 2.3%, respectively and for the LSE-GM-CSA were 3.8% and 5.4%, respectively. Mean (± SD) WM-MTR was 43.2 (± 4.4) and GM-MTR was 40.9 (± 4.3). The mean scan-rescan % COV for measuring WM-MTR was 4.6% and for GM-MTR was 3.8%. Using a paired t-test, a statistically significant difference was identified between WM-MTR and GM-MTR in the LSE (p<0.0001). This pilot study has shown that it is possible to obtain reliable tissue-specific MTR measurements within the LSE using a clinical MR system at 3T. The MTR acquisition and analysis protocol presented in this study can be used in future investigations of intrinsic spinal cord diseases that affect the LSE.
AbstractList	Magnetisation transfer (MT) imaging of the central nervous system has provided further insight into the pathophysiology of neurological disease. However, the use of this method to study the lower spinal cord has been technically challenging, despite the important role of this region, not only for motor control of the lower limbs, but also for the neural control of lower urinary tract, sexual and bowel functions. In this study, the feasibility of obtaining reliable grey matter (GM) and white matter (WM) magnetisation transfer ratio (MTR) measurements within the lumbosacral enlargement (LSE) was investigated in ten healthy volunteers using a clinical 3T MRI system. The mean cross-sectional area of the LSE (LSE-CSA) and the mean GM area (LSE-GM-CSA) were first obtained by means of image segmentation and tissue-specific (i.e. WM and GM) MTR measurements within the LSE were subsequently obtained. The reproducibility of the segmentation method and MTR measurements was assessed from repeated measurements and their % coefficient of variation (%COV). Mean (± SD) LSE-CSA across 10 healthy subjects was 59.3 (± 8.4) mm2 and LSE-GM-CSA was 17.0 (± 3.1) mm2. The mean intra- and inter-rater % COV for measuring the LSE-CSA were 0.8% and 2.3%, respectively and for the LSE-GM-CSA were 3.8% and 5.4%, respectively. Mean (± SD) WM-MTR was 43.2 (± 4.4) and GM-MTR was 40.9 (± 4.3). The mean scan-rescan % COV for measuring WM-MTR was 4.6% and for GM-MTR was 3.8%. Using a paired t-test, a statistically significant difference was identified between WM-MTR and GM-MTR in the LSE (p<0.0001). This pilot study has shown that it is possible to obtain reliable tissue-specific MTR measurements within the LSE using a clinical MR system at 3T. The MTR acquisition and analysis protocol presented in this study can be used in future investigations of intrinsic spinal cord diseases that affect the LSE. Magnetisation transfer (MT) imaging of the central nervous system has provided further insight into the pathophysiology of neurological disease. However, the use of this method to study the lower spinal cord has been technically challenging, despite the important role of this region, not only for motor control of the lower limbs, but also for the neural control of lower urinary tract, sexual and bowel functions. In this study, the feasibility of obtaining reliable grey matter (GM) and white matter (WM) magnetisation transfer ratio (MTR) measurements within the lumbosacral enlargement (LSE) was investigated in ten healthy volunteers using a clinical 3T MRI system. The mean cross-sectional area of the LSE (LSE-CSA) and the mean GM area (LSE-GM-CSA) were first obtained by means of image segmentation and tissue-specific (i.e. WM and GM) MTR measurements within the LSE were subsequently obtained. The reproducibility of the segmentation method and MTR measurements was assessed from repeated measurements and their % coefficient of variation (%COV). Mean (± SD) LSE-CSA across 10 healthy subjects was 59.3 (± 8.4) mm.sup.2 and LSE-GM-CSA was 17.0 (± 3.1) mm.sup.2 . The mean intra- and inter-rater % COV for measuring the LSE-CSA were 0.8% and 2.3%, respectively and for the LSE-GM-CSA were 3.8% and 5.4%, respectively. Mean (± SD) WM-MTR was 43.2 (± 4.4) and GM-MTR was 40.9 (± 4.3). The mean scan-rescan % COV for measuring WM-MTR was 4.6% and for GM-MTR was 3.8%. Using a paired t-test, a statistically significant difference was identified between WM-MTR and GM-MTR in the LSE (p<0.0001). This pilot study has shown that it is possible to obtain reliable tissue-specific MTR measurements within the LSE using a clinical MR system at 3T. The MTR acquisition and analysis protocol presented in this study can be used in future investigations of intrinsic spinal cord diseases that affect the LSE.
Audience	Academic
Author	Panicker, Jalesh N. Miller, David H. Ugorji, Chinyere O. Wheeler-Kingshott, Claudia A. M. Yiannakas, Marios C. Liechti, Martina D. Samson, Rebecca S.
AuthorAffiliation	Heidelberg University Hospital, GERMANY 2 Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery and UCL Institute of Neurology, London, United Kingdom 1 NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom
AuthorAffiliation_xml	– name: 2 Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery and UCL Institute of Neurology, London, United Kingdom – name: Heidelberg University Hospital, GERMANY – name: 1 NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom
Author_xml	– sequence: 1 givenname: Chinyere O. surname: Ugorji fullname: Ugorji, Chinyere O. – sequence: 2 givenname: Rebecca S. surname: Samson fullname: Samson, Rebecca S. – sequence: 3 givenname: Martina D. surname: Liechti fullname: Liechti, Martina D. – sequence: 4 givenname: Jalesh N. surname: Panicker fullname: Panicker, Jalesh N. – sequence: 5 givenname: David H. surname: Miller fullname: Miller, David H. – sequence: 6 givenname: Claudia A. M. surname: Wheeler-Kingshott fullname: Wheeler-Kingshott, Claudia A. M. – sequence: 7 givenname: Marios C. surname: Yiannakas fullname: Yiannakas, Marios C.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26230729$$D View this record in MEDLINE/PubMed
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CitedBy_id	crossref_primary_10_1007_s00415_019_09597_2 crossref_primary_10_1038_s41598_020_71570_1 crossref_primary_10_3390_jimaging10090213 crossref_primary_10_1016_j_neuroimage_2018_04_009
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DocumentTitleAlternate	In Vivo MTR Measurements in the Lumbosacral Enlargement
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: CU RS CW MY. Performed the experiments: CU RS ML MY. Analyzed the data: CU MY ML. Contributed reagents/materials/analysis tools: MY JP DM CW. Wrote the paper: CU RS ML JP DM CW MY.
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Snippet	Magnetisation transfer (MT) imaging of the central nervous system has provided further insight into the pathophysiology of neurological disease. However, the...
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SubjectTerms	Adult Amyotrophic lateral sclerosis Brain research Central nervous system Coefficient of variation Enlargement Feasibility studies Female Gray Matter - anatomy & histology Healthy Volunteers Humans Image processing Image segmentation In vivo methods and tests Intestine Lumbar Vertebrae - anatomy & histology Magnetic Resonance Imaging Magnetics Magnetization Male Measurement Medical imaging equipment Motor task performance Multiple sclerosis Nervous system diseases Neurology Neurosurgery NMR Nuclear magnetic resonance Pilot Projects Reproducibility Sacrum - anatomy & histology Spinal cord Spinal cord injuries Statistical analysis Substantia alba Substantia grisea Urinary tract White Matter - anatomy & histology
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Title	Grey and White Matter Magnetisation Transfer Ratio Measurements in the Lumbosacral Enlargement: A Pilot In Vivo Study at 3T
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