Grey and White Matter Magnetisation Transfer Ratio Measurements in the Lumbosacral Enlargement: A Pilot In Vivo Study at 3T

Magnetisation transfer (MT) imaging of the central nervous system has provided further insight into the pathophysiology of neurological disease. However, the use of this method to study the lower spinal cord has been technically challenging, despite the important role of this region, not only for mo...

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Vydané v:PloS one Ročník 10; číslo 7; s. e0134495
Hlavní autori: Ugorji, Chinyere O., Samson, Rebecca S., Liechti, Martina D., Panicker, Jalesh N., Miller, David H., Wheeler-Kingshott, Claudia A. M., Yiannakas, Marios C.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Public Library of Science 31.07.2015
Public Library of Science (PLoS)
Predmet:
Adult
Amyotrophic lateral sclerosis
Brain research
Central nervous system
Coefficient of variation
Enlargement
Feasibility studies
Female
Gray Matter - anatomy & histology
Healthy Volunteers
Humans
Image processing
Image segmentation
In vivo methods and tests
Intestine
Lumbar Vertebrae - anatomy & histology
Magnetic Resonance Imaging
Magnetics
Magnetization
Male
Measurement
Medical imaging equipment
Motor task performance
Multiple sclerosis
Nervous system diseases
Neurology
Neurosurgery
NMR
Nuclear magnetic resonance
Pilot Projects
Reproducibility
Sacrum - anatomy & histology
Spinal cord
Spinal cord injuries
Statistical analysis
Substantia alba
Substantia grisea
Urinary tract
White Matter - anatomy & histology
ISSN:1932-6203, 1932-6203
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Shrnutí:Magnetisation transfer (MT) imaging of the central nervous system has provided further insight into the pathophysiology of neurological disease. However, the use of this method to study the lower spinal cord has been technically challenging, despite the important role of this region, not only for motor control of the lower limbs, but also for the neural control of lower urinary tract, sexual and bowel functions. In this study, the feasibility of obtaining reliable grey matter (GM) and white matter (WM) magnetisation transfer ratio (MTR) measurements within the lumbosacral enlargement (LSE) was investigated in ten healthy volunteers using a clinical 3T MRI system. The mean cross-sectional area of the LSE (LSE-CSA) and the mean GM area (LSE-GM-CSA) were first obtained by means of image segmentation and tissue-specific (i.e. WM and GM) MTR measurements within the LSE were subsequently obtained. The reproducibility of the segmentation method and MTR measurements was assessed from repeated measurements and their % coefficient of variation (%COV). Mean (± SD) LSE-CSA across 10 healthy subjects was 59.3 (± 8.4) mm2 and LSE-GM-CSA was 17.0 (± 3.1) mm2. The mean intra- and inter-rater % COV for measuring the LSE-CSA were 0.8% and 2.3%, respectively and for the LSE-GM-CSA were 3.8% and 5.4%, respectively. Mean (± SD) WM-MTR was 43.2 (± 4.4) and GM-MTR was 40.9 (± 4.3). The mean scan-rescan % COV for measuring WM-MTR was 4.6% and for GM-MTR was 3.8%. Using a paired t-test, a statistically significant difference was identified between WM-MTR and GM-MTR in the LSE (p<0.0001). This pilot study has shown that it is possible to obtain reliable tissue-specific MTR measurements within the LSE using a clinical MR system at 3T. The MTR acquisition and analysis protocol presented in this study can be used in future investigations of intrinsic spinal cord diseases that affect the LSE.
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: CU RS CW MY. Performed the experiments: CU RS ML MY. Analyzed the data: CU MY ML. Contributed reagents/materials/analysis tools: MY JP DM CW. Wrote the paper: CU RS ML JP DM CW MY.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0134495