Point-of-care, smartphone-based, dual-modality, dual-view, oral cancer screening device with neural network classification for low-resource communities
Oral cancer is a growing health issue in a number of low- and middle-income countries (LMIC), particularly in South and Southeast Asia. The described dual-modality, dual-view, point-of-care oral cancer screening device, developed for high-risk populations in remote regions with limited infrastructur...
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| Published in: | PloS one Vol. 13; no. 12; p. e0207493 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Public Library of Science
05.12.2018
Public Library of Science (PLoS) |
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| ISSN: | 1932-6203, 1932-6203 |
| Online Access: | Get full text |
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| Abstract | Oral cancer is a growing health issue in a number of low- and middle-income countries (LMIC), particularly in South and Southeast Asia. The described dual-modality, dual-view, point-of-care oral cancer screening device, developed for high-risk populations in remote regions with limited infrastructure, implements autofluorescence imaging (AFI) and white light imaging (WLI) on a smartphone platform, enabling early detection of pre-cancerous and cancerous lesions in the oral cavity with the potential to reduce morbidity, mortality, and overall healthcare costs. Using a custom Android application, this device synchronizes external light-emitting diode (LED) illumination and image capture for AFI and WLI. Data is uploaded to a cloud server for diagnosis by a remote specialist through a web app, with the ability to transmit triage instructions back to the device and patient. Finally, with the on-site specialist's diagnosis as the gold-standard, the remote specialist and a convolutional neural network (CNN) were able to classify 170 image pairs into 'suspicious' and 'not suspicious' with sensitivities, specificities, positive predictive values, and negative predictive values ranging from 81.25% to 94.94%. |
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| AbstractList | Oral cancer is a growing health issue in a number of low- and middle-income countries (LMIC), particularly in South and Southeast Asia. The described dual-modality, dual-view, point-of-care oral cancer screening device, developed for high-risk populations in remote regions with limited infrastructure, implements autofluorescence imaging (AFI) and white light imaging (WLI) on a smartphone platform, enabling early detection of pre-cancerous and cancerous lesions in the oral cavity with the potential to reduce morbidity, mortality, and overall healthcare costs. Using a custom Android application, this device synchronizes external light-emitting diode (LED) illumination and image capture for AFI and WLI. Data is uploaded to a cloud server for diagnosis by a remote specialist through a web app, with the ability to transmit triage instructions back to the device and patient. Finally, with the on-site specialist's diagnosis as the gold-standard, the remote specialist and a convolutional neural network (CNN) were able to classify 170 image pairs into 'suspicious' and 'not suspicious' with sensitivities, specificities, positive predictive values, and negative predictive values ranging from 81.25% to 94.94%. Oral cancer is a growing health issue in a number of low- and middle-income countries (LMIC), particularly in South and Southeast Asia. The described dual-modality, dual-view, point-of-care oral cancer screening device, developed for high-risk populations in remote regions with limited infrastructure, implements autofluorescence imaging (AFI) and white light imaging (WLI) on a smartphone platform, enabling early detection of pre-cancerous and cancerous lesions in the oral cavity with the potential to reduce morbidity, mortality, and overall healthcare costs. Using a custom Android application, this device synchronizes external light-emitting diode (LED) illumination and image capture for AFI and WLI. Data is uploaded to a cloud server for diagnosis by a remote specialist through a web app, with the ability to transmit triage instructions back to the device and patient. Finally, with the on-site specialist's diagnosis as the gold-standard, the remote specialist and a convolutional neural network (CNN) were able to classify 170 image pairs into 'suspicious' and 'not suspicious' with sensitivities, specificities, positive predictive values, and negative predictive values ranging from 81.25% to 94.94%.Oral cancer is a growing health issue in a number of low- and middle-income countries (LMIC), particularly in South and Southeast Asia. The described dual-modality, dual-view, point-of-care oral cancer screening device, developed for high-risk populations in remote regions with limited infrastructure, implements autofluorescence imaging (AFI) and white light imaging (WLI) on a smartphone platform, enabling early detection of pre-cancerous and cancerous lesions in the oral cavity with the potential to reduce morbidity, mortality, and overall healthcare costs. Using a custom Android application, this device synchronizes external light-emitting diode (LED) illumination and image capture for AFI and WLI. Data is uploaded to a cloud server for diagnosis by a remote specialist through a web app, with the ability to transmit triage instructions back to the device and patient. Finally, with the on-site specialist's diagnosis as the gold-standard, the remote specialist and a convolutional neural network (CNN) were able to classify 170 image pairs into 'suspicious' and 'not suspicious' with sensitivities, specificities, positive predictive values, and negative predictive values ranging from 81.25% to 94.94%. |
| Audience | Academic |
| Author | Kuriakose, Moni Abraham Birur, Praveen Uthoff, Ross D. Spires, Oliver Keerthi, G. Patrick, Sanjana Sunny, Sumsum Anbarani, Afarin Kolur, Trupti Wilder-Smith, Petra Suresh, Amritha Liang, Rongguang Song, Bofan |
| AuthorAffiliation | 4 Biocon Foundation, Bangalore, India 5 KLE Society’s Institute of Dental Sciences, Bangalore, India 1 College of Optical Sciences, The University of Arizona, Tucson, Arizona, United States of America 2 Mazumdar Shaw Medical Centre, Bangalore, India 6 Beckman Laser Institute, University of California, Irvine, Irvine, California, United States of America 3 Mazumdar Shaw Medical Foundation, Bangalore, India Texas A&M University, UNITED STATES |
| AuthorAffiliation_xml | – name: 3 Mazumdar Shaw Medical Foundation, Bangalore, India – name: 2 Mazumdar Shaw Medical Centre, Bangalore, India – name: 4 Biocon Foundation, Bangalore, India – name: 6 Beckman Laser Institute, University of California, Irvine, Irvine, California, United States of America – name: 5 KLE Society’s Institute of Dental Sciences, Bangalore, India – name: 1 College of Optical Sciences, The University of Arizona, Tucson, Arizona, United States of America – name: Texas A&M University, UNITED STATES |
| Author_xml | – sequence: 1 givenname: Ross D. orcidid: 0000-0003-1002-5546 surname: Uthoff fullname: Uthoff, Ross D. – sequence: 2 givenname: Bofan orcidid: 0000-0002-1171-8478 surname: Song fullname: Song, Bofan – sequence: 3 givenname: Sumsum surname: Sunny fullname: Sunny, Sumsum – sequence: 4 givenname: Sanjana surname: Patrick fullname: Patrick, Sanjana – sequence: 5 givenname: Amritha orcidid: 0000-0002-0785-0054 surname: Suresh fullname: Suresh, Amritha – sequence: 6 givenname: Trupti surname: Kolur fullname: Kolur, Trupti – sequence: 7 givenname: G. orcidid: 0000-0003-4594-8674 surname: Keerthi fullname: Keerthi, G. – sequence: 8 givenname: Oliver surname: Spires fullname: Spires, Oliver – sequence: 9 givenname: Afarin surname: Anbarani fullname: Anbarani, Afarin – sequence: 10 givenname: Petra surname: Wilder-Smith fullname: Wilder-Smith, Petra – sequence: 11 givenname: Moni Abraham surname: Kuriakose fullname: Kuriakose, Moni Abraham – sequence: 12 givenname: Praveen surname: Birur fullname: Birur, Praveen – sequence: 13 givenname: Rongguang surname: Liang fullname: Liang, Rongguang |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30517120$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.5244/C.28.6 10.1136/bmj.308.6943.1552 10.1016/S1470-2045(09)70335-3 10.1146/annurev.physchem.47.1.555 10.14219/jada.archive.2010.0132 10.1002/(SICI)1097-0347(199701)19:1<27::AID-HED5>3.0.CO;2-X 10.1016/j.tripleo.2010.12.010 10.1080/13556210120091446 10.1117/1.2907455 10.1001/archotol.1996.01890230029007 10.1016/j.genm.2011.09.031 10.1177/03946320110240S221 10.1158/1940-6207.CAPR-11-0555 10.1016/j.oraloncology.2010.01.017 10.1364/AO.54.002224 10.1002/hed.21834 10.1038/s41598-017-12320-8 10.1117/1.2193157 10.1111/j.1751-1097.1998.tb02521.x 10.1080/13556210020091437 10.1016/j.oraloncology.2004.01.005 10.1002/lsm.20122 10.1038/ijos.2014.39 10.1007/s12070-011-0134-9 10.1093/clinchem/39.4.561 10.1002/lsm.10185 10.1002/hed.20468 10.1177/1010539513486921 10.1109/ICITEED.2015.7408943 10.1126/science.3287615 10.1016/j.surge.2011.01.010 10.1111/j.1600-0714.1995.tb01132.x 10.4317/jced.51318 10.1562/0031-8655(2000)072<0103:OEWFIV>2.0.CO;2 10.4103/2231-0762.159967 10.1146/annurev-bioeng-071516-044442 10.1158/1940-6207.CAPR-08-0229 10.1002/ijc.2910540508 10.1001/jamadermatol.2013.7965 10.1016/j.genm.2011.11.006 10.1016/j.oraloncology.2004.07.007 10.4103/0973-029X.92965 10.1002/hed.10381 10.1016/j.oraloncology.2011.02.001 10.1109/TKDE.2009.191 10.1002/9780470175637.ch3 10.1364/OE.18.017460 10.1109/CVPR.2009.5206848 10.1111/jop.12218 10.1038/bjc.1971.2 10.1111/j.1349-7006.2008.00863.x 10.1016/S1470-2045(01)00444-2 10.1117/1.2904658 10.1016/S0140-6736(05)66658-5 10.1364/AO.47.000825 10.1136/bmj.309.6947.102 10.1002/ijc.29210 10.1002/cncr.23324 10.1111/j.1600-0528.2005.00251.x 10.1016/S1368-8375(01)00003-3 10.1038/nature21056 10.1366/0003702991946695 10.1080/13556210120091464 10.4103/0971-5851.133702 10.1016/1011-1344(93)80127-U |
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| Copyright | COPYRIGHT 2018 Public Library of Science 2018 Uthoff et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2018 Uthoff et al 2018 Uthoff et al |
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| References | RJ Mallia (ref40) 2008; 112 MH Zweig (ref77) 1993; 39 DV Messadi (ref49) 2014; 6 PE Petersen (ref1) 2005; 33 R Mehrotra (ref55) 2010; 141 HK Amarasinghe (ref11) 2010; 46 RD Uthoff (ref57) 2018; vol. 10486 JK Dhingra (ref32) 1996; 122 AdC Batlle (ref47) 1993; 20 D Sawan (ref52) 2015; 5 R Ongole (ref68) 2010 ref93 ref92 GT Fechner (ref84) 1966 R Sankaranarayanan (ref7) 2010; 11 NK Wood (ref66) 1991 ref91 ref90 ref46 ref89 A Zuluaga (ref39) 1999; 53 A Esteva (ref71) 2017; 542 R Prabhu (ref21) 2014; 6 J Ferlay (ref6) 2015; 136 ref85 PM Lane (ref34) 2012; 9 DCG de Veld (ref38) 2005; 36 CS Farah (ref45) 2012; 34 J Reidy (ref10) 2011; 9 D Roblyer (ref81) 2008; 13 RA Schwarz (ref33) 2008; 47 GA Wagnieres (ref43) 1998; 68 (ref2) 2006 MA Lynch (ref67) 1994 CF Poh (ref41) 2007; 29 ref3 JH Jeng (ref15) 2001; 37 ref5 YJ Chen (ref18) 2008; 99 ref82 AK Agarwal (ref4) 2011; 63 DCG de Veld (ref36) 2003; 32 ref83 R Sankaranarayanan (ref27) 2005; 365 SR Ponnam (ref19) 2012; 16 M Aubreville (ref72) 2017; 7 DR Ingrams (ref31) 1997; 19 ref79 DC Sharma (ref14) 2001; 2 ref78 M Rahman (ref80) 2008; 13 Z Qin (ref65) 2010; 18 SJ Pan (ref69) 2010; 22 Y Wu (ref88) 2006; 11 JJ Pindborg (ref8) 1971; 25 D Roblyer (ref30) 2009; 2 H Song (ref12) 2015; 27 AB Ram (ref23) 1902; 37 YC Ko (ref13) 1995; 24 PM Lane (ref35) 2012; 9 D Shen (ref56) 2017; 19 DCG de Veld (ref37) 2005; 41 KH Awan (ref50) 2011; 47 A Garg (ref25) 2014; 35 PM Lane (ref42) 2006; 11 ref70 ref73 PC Gupta (ref16) 2002; 7 SS Strickland (ref26) 2002; 7 DL Heintzelman (ref28) 2000; 72 MS Rahman (ref87) 2010; 2 ref64 J Swets (ref76) 1988; 240 R Richards-Kortum (ref44) 1996; 47 ref63 ref22 MDGH Vicente (ref48) 1996; 3 C Paderni (ref53) 2011; 24 R Kingslake (ref58) 2009 DG Altman (ref74) 1994; 308 LM Bicknell (ref20) 2013; 149 MC Pierce (ref59) 2012; 5 A Rashid (ref54) 2015; 44 BJ Jacob (ref17) 2004; 40 M Scheer (ref51) 2011; 111 MM Van der Eb (ref9) 1993; 54 ref60 ref62 E Svistun (ref29) 2004; 26 ref61 BJ Boucher (ref24) 2002; 7 DG Altman (ref75) 1994; 309 JE Harvey (ref86) 2015; 54 |
| References_xml | – ident: ref62 – ident: ref70 doi: 10.5244/C.28.6 – volume: 308 start-page: 1552 issue: 6943 year: 1994 ident: ref74 article-title: Diagnostic Tests. 1: Sensitivity and Specificity publication-title: BMJ doi: 10.1136/bmj.308.6943.1552 – volume: 11 start-page: 165 issue: 2 year: 2010 ident: ref7 article-title: Cancer Survival in Africa, Asia, and Central America: A Population-Based Study publication-title: Lancet Oncol doi: 10.1016/S1470-2045(09)70335-3 – ident: ref89 – ident: ref5 – volume: 47 start-page: 555 issue: 1 year: 1996 ident: ref44 article-title: Quantitative Optical Spectroscopy for Tissue Diagnosis publication-title: Annu Rev Phys Chem doi: 10.1146/annurev.physchem.47.1.555 – ident: ref91 – volume: 141 start-page: 151 issue: 2 year: 2010 ident: ref55 article-title: A Cross-Sectional Study Evaluating Chemiluminescence and Autofluorescence in the Detection of Clinically Innocuous Precancerous and Cancerous Oral Lesions publication-title: The Journal of the American Dental Association doi: 10.14219/jada.archive.2010.0132 – volume: 19 start-page: 27 issue: 1 year: 1997 ident: ref31 article-title: Autofluorescence Characteristics of Oral Mucosa publication-title: Head Neck doi: 10.1002/(SICI)1097-0347(199701)19:1<27::AID-HED5>3.0.CO;2-X – volume: 111 start-page: 568 issue: 5 year: 2011 ident: ref51 article-title: Autofluorescence Imaging of Potentially Malignant Mucosa Lesions publication-title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics doi: 10.1016/j.tripleo.2010.12.010 – year: 2006 ident: ref2 article-title: Age-Standardized Death Rates per 100,000 by Cause – volume: 7 start-page: 85 issue: 1 year: 2002 ident: ref26 article-title: Anthropological Perspectives on Use of the Areca Nut publication-title: Addict Biol doi: 10.1080/13556210120091446 – volume: 13 start-page: 030502 issue: 3 year: 2008 ident: ref80 article-title: Low-Cost, Multimodal, Portable Screening System for Early Detection of Oral Cancer publication-title: J Biomed Opt doi: 10.1117/1.2907455 – volume: 122 start-page: 1181 year: 1996 ident: ref32 article-title: Diagnosis of Upper Aerodigestive Tract Cancer by Autofluorescence publication-title: Arch Otolaryngol Head Neck Surg doi: 10.1001/archotol.1996.01890230029007 – volume: 9 start-page: S25 issue: 1S year: 2012 ident: ref34 article-title: Has Fluorescence Spectroscopy Come of Age? A Case Series of Oral Precancers and Cancers Using White Light, Fluorescent Light at 405 Nm, and Reflected Light at 545 Nm Using the Trimira Identafi 3000 publication-title: Gend Med doi: 10.1016/j.genm.2011.09.031 – volume: 24 start-page: 121 issue: 2_suppl year: 2011 ident: ref53 article-title: Direct Visualization of Oral-Cavity Tissue Fluorescence as Novel Aid for Early Oral Cancer Diagnosis and Potentially Malignant Disorders Monitoring publication-title: Int J Immunopathol Pharmacol doi: 10.1177/03946320110240S221 – volume: 5 start-page: 801 issue: 6 year: 2012 ident: ref59 article-title: Accuracy of in Vivo Multimodal Optical Imaging for Detection of Oral Neoplasia publication-title: Cancer Prev Res (Phila Pa) doi: 10.1158/1940-6207.CAPR-11-0555 – year: 1994 ident: ref67 article-title: Burket’s Oral Medicine: Diagnosis and Treatment – volume: 46 start-page: 297 issue: 4 year: 2010 ident: ref11 article-title: Betel-Quid Chewing with or without Tobacco Is a Major Risk Factor for Oral Potentially Malignant Disorders in Sri Lanka: A Case-Control Study publication-title: Oral Oncol doi: 10.1016/j.oraloncology.2010.01.017 – ident: ref61 – volume: 54 start-page: 2224 issue: 9 year: 2015 ident: ref86 article-title: Integrating Optical Fabrication and Metrology into the Optical Design Process publication-title: Appl Opt doi: 10.1364/AO.54.002224 – volume: 34 start-page: 856 issue: 6 year: 2012 ident: ref45 article-title: Efficacy of Tissue Autofluorescence Imaging (Velscope) in the Visualization of Oral Mucosal Lesions publication-title: Head Neck doi: 10.1002/hed.21834 – volume: 7 start-page: 11979 issue: 1 year: 2017 ident: ref72 article-title: Automatic Classification of Cancerous Tissue in Laserendomicroscopy Images of the Oral Cavity Using Deep Learning publication-title: Sci Rep doi: 10.1038/s41598-017-12320-8 – ident: ref82 – volume: 11 start-page: 024006 issue: 2 year: 2006 ident: ref42 article-title: Simple Device for the Direct Visualization of Oral-Cavity Tissue Fluorescence publication-title: J Biomed Opt doi: 10.1117/1.2193157 – volume: 68 start-page: 603 issue: 5 year: 1998 ident: ref43 article-title: In Vivo Fluorescence Spectroscopy and Imaging for Oncological Applications publication-title: Photochem Photobiol doi: 10.1111/j.1751-1097.1998.tb02521.x – volume: 7 start-page: 77 issue: 1 year: 2002 ident: ref16 article-title: Global Epidemiology of Areca Nut Usage publication-title: Addict Biol doi: 10.1080/13556210020091437 – volume: 40 start-page: 697 issue: 7 year: 2004 ident: ref17 article-title: Betel Quid without Tobacco as a Risk Factor for Oral Precancers publication-title: Oral Oncol doi: 10.1016/j.oraloncology.2004.01.005 – volume: 36 start-page: 356 issue: 5 year: 2005 ident: ref38 article-title: Autofluorescence and Diffuse Reflectance Spectroscopy for Oral Oncology publication-title: Lasers Surg Med doi: 10.1002/lsm.20122 – volume: 6 start-page: 162 issue: 3 year: 2014 ident: ref49 article-title: The Clinical Effectiveness of Reflectance Optical Spectroscopy for the in Vivo Diagnosis of Oral Lesions publication-title: Int J Oral Sci doi: 10.1038/ijos.2014.39 – ident: ref79 – volume: 63 start-page: 145 issue: 2 year: 2011 ident: ref4 article-title: Treatment Delay in Oral and Oropharyngeal Cancer in Our Population: The Role of Socio-Economic Factors and Health-Seeking Behaviour publication-title: Indian J Otolaryngol Head Neck Surg doi: 10.1007/s12070-011-0134-9 – volume: 39 start-page: 561 issue: 4 year: 1993 ident: ref77 article-title: Receiver-Operating Characteristic (ROC) Plots: A Fundamental Evaluation Tool in Clinical Medicine publication-title: Clin Chem doi: 10.1093/clinchem/39.4.561 – ident: ref92 – volume: 32 start-page: 367 issue: 5 year: 2003 ident: ref36 article-title: Autofluorescence Characteristics of Healthy Oral Mucosa at Different Anatomical Sites publication-title: Lasers Surg Med doi: 10.1002/lsm.10185 – volume: 29 start-page: 71 issue: 1 year: 2007 ident: ref41 article-title: Direct Fluorescence Visualization of Clinically Occult High-Risk Oral Premalignant Disease Using a Simple Hand-Held Device publication-title: Head Neck doi: 10.1002/hed.20468 – volume: 27 start-page: NP47 issue: 2 year: 2015 ident: ref12 article-title: Betel Quid Chewing Without Tobacco: A Meta-Analysis of Carcinogenic and Precarcinogenic Effects publication-title: Asia Pac J Public Health doi: 10.1177/1010539513486921 – ident: ref85 doi: 10.1109/ICITEED.2015.7408943 – volume: 240 start-page: 1285 issue: 4857 year: 1988 ident: ref76 article-title: Measuring the Accuracy of Diagnostic Systems publication-title: Science doi: 10.1126/science.3287615 – volume: 11 start-page: 054023 issue: 5 year: 2006 ident: ref88 article-title: Autofluorescence Spectroscopy of Epithelial Tissues publication-title: JBO, JBOPFO – ident: ref3 – volume: 9 start-page: 278 issue: 5 year: 2011 ident: ref10 article-title: A Review of the Relationship between Alcohol and Oral Cancer publication-title: The Surgeon doi: 10.1016/j.surge.2011.01.010 – ident: ref83 – volume: 24 start-page: 450 issue: 10 year: 1995 ident: ref13 article-title: Betel Quid Chewing, Cigarette Smoking and Alcohol Consumption Related to Oral Cancer in Taiwan publication-title: J Oral Pathol Med doi: 10.1111/j.1600-0714.1995.tb01132.x – volume: 6 start-page: e569 issue: 5 year: 2014 ident: ref21 article-title: Areca Nut and Its Role in Oral Submucous Fibrosis publication-title: J Clin Exp Dent doi: 10.4317/jced.51318 – ident: ref60 – year: 1991 ident: ref66 article-title: Differential Diagnosis of Oral Lesions – ident: ref22 – volume: 72 start-page: 103 issue: 1 year: 2000 ident: ref28 article-title: Optimal Excitation Wavelengths for In Vivo Detection of Oral Neoplasia Using Fluorescence Spectroscopy publication-title: J Photochem Photobiol doi: 10.1562/0031-8655(2000)072<0103:OEWFIV>2.0.CO;2 – volume: 5 start-page: 248 issue: 3 year: 2015 ident: ref52 article-title: Evaluation of Premalignant and Malignant Lesions by Fluorescent Light (VELscope) publication-title: J Int Soc Prev Community Dent doi: 10.4103/2231-0762.159967 – volume: 19 start-page: 221 issue: 1 year: 2017 ident: ref56 article-title: Deep Learning in Medical Image Analysis publication-title: Annu Rev Biomed Eng doi: 10.1146/annurev-bioeng-071516-044442 – volume: 2 start-page: 423 issue: 5 year: 2009 ident: ref30 article-title: Objective Detection and Delineation of Oral Neoplasia Using Autofluorescence Imaging publication-title: Cancer Prev Res (Phila Pa) doi: 10.1158/1940-6207.CAPR-08-0229 – volume: 54 start-page: 754 issue: 5 year: 1993 ident: ref9 article-title: Reverse Smoking as a Risk Factor for Palatal Cancer: A Cross-Sectional Study in Rural Andhra Pradesh, India publication-title: Int J Cancer doi: 10.1002/ijc.2910540508 – volume: 149 start-page: 1288 issue: 11 year: 2013 ident: ref20 article-title: Lips as Red as Blood: Areca Nut Lip Staining publication-title: JAMA Dermatol doi: 10.1001/jamadermatol.2013.7965 – year: 1966 ident: ref84 article-title: Elements of Psychophysics – year: 2009 ident: ref58 article-title: Lens Design Fundamentals – ident: ref78 – volume: 2 start-page: 8 issue: 10 year: 2010 ident: ref87 article-title: Evaluation of a Low-Cost, Portable Imaging System for Early Detection of Oral Cancer publication-title: Head Neck Oncol – ident: ref93 – volume: 9 start-page: S78 issue: 1S year: 2012 ident: ref35 article-title: Oral Fluorescence Imaging Using 405-Nm Excitation, Aiding the Discrimination of Cancers and Precancers by Identifying Changes in Collagen and Elastic Breakdown and Neovascularization in the Underlying Stroma publication-title: Gend Med doi: 10.1016/j.genm.2011.11.006 – volume: 41 start-page: 117 issue: 2 year: 2005 ident: ref37 article-title: The Status of in Vivo Autofluorescence Spectroscopy and Imaging for Oral Oncology publication-title: Oral Oncol doi: 10.1016/j.oraloncology.2004.07.007 – volume: 16 start-page: 4 issue: 1 year: 2012 ident: ref19 article-title: Autofluorescence Spectroscopy of Betel Quid Chewers and Oral Submucous Fibrosis: A Pilot Study publication-title: J Oral Maxillofac Pathol doi: 10.4103/0973-029X.92965 – volume: 26 start-page: 205 issue: 3 year: 2004 ident: ref29 article-title: Vision Enhancement System for Detection of Oral Cavity Neoplasia Based on Autofluorescence publication-title: Head Neck doi: 10.1002/hed.10381 – volume: 47 start-page: 274 issue: 4 year: 2011 ident: ref50 article-title: Evaluation of an Autofluorescence Based Imaging System (VELscope™) in the Detection of Oral Potentially Malignant Disorders and Benign Keratoses publication-title: Oral Oncology doi: 10.1016/j.oraloncology.2011.02.001 – year: 2010 ident: ref68 article-title: Text Book of Oral Medicine, Oral Diagnosis and Oral Radiology – volume: 37 start-page: 414 issue: 10 year: 1902 ident: ref23 article-title: The Use of Betelnut as a Cause of Cancer in Malabar publication-title: Indian Med Gaz – ident: ref63 – volume: 22 start-page: 1345 issue: 10 year: 2010 ident: ref69 article-title: A Survey on Transfer Learning publication-title: IEEE Trans Knowl Data Eng doi: 10.1109/TKDE.2009.191 – ident: ref90 – ident: ref64 doi: 10.1002/9780470175637.ch3 – volume: 18 start-page: 17460 issue: 16 year: 2010 ident: ref65 article-title: Analysis of Condition for Uniform Lighting Generated by Array of Light Emitting Diodes with Large View Angle publication-title: Opt Express doi: 10.1364/OE.18.017460 – ident: ref73 doi: 10.1109/CVPR.2009.5206848 – volume: 44 start-page: 307 issue: 5 year: 2015 ident: ref54 article-title: The Use of Light-Based (Optical) Detection Systems as Adjuncts in the Detection of Oral Cancer and Oral Potentially Malignant Disorders: A Systematic Review publication-title: J Oral Pathol Med doi: 10.1111/jop.12218 – ident: ref46 – volume: 25 start-page: 10 issue: 1 year: 1971 ident: ref8 article-title: Reverse Smoking in Andhra Pradesh, India: A Study of Palatal Lesions among 10,169 Villagers publication-title: Br J Cancer doi: 10.1038/bjc.1971.2 – volume: 99 start-page: 1507 issue: 8 year: 2008 ident: ref18 article-title: Head and Neck Cancer in the Betel Quid Chewing Area: Recent Advances in Molecular Carcinogenesis publication-title: Cancer Sci doi: 10.1111/j.1349-7006.2008.00863.x – volume: 2 start-page: 464 issue: 8 year: 2001 ident: ref14 article-title: Indian Betel Quid More Carcinogenic than Anticipated publication-title: Lancet Oncol doi: 10.1016/S1470-2045(01)00444-2 – volume: 13 start-page: 024019 issue: 2 year: 2008 ident: ref81 article-title: Multispectral Optical Imaging Device for in Vivo Detection of Oral Neoplasia publication-title: J Biomed Opt doi: 10.1117/1.2904658 – volume: vol. 10486 start-page: 104860V year: 2018 ident: ref57 article-title: Proc. SPIE 10486, Design and Quality for Biomedical Technologies XI – volume: 365 start-page: 1927 issue: 9475 year: 2005 ident: ref27 article-title: Effect of Screening on Oral Cancer Mortality in Kerala, India: A Cluster-Randomised Controlled Trial publication-title: The Lancet doi: 10.1016/S0140-6736(05)66658-5 – volume: 47 start-page: 825 issue: 6 year: 2008 ident: ref33 article-title: Autofluorescence and Diffuse Reflectance Spectroscopy of Oral Epithelial Tissue Using a Depth-Sensitive Fiber-Optic Probe publication-title: Appl Opt doi: 10.1364/AO.47.000825 – volume: 309 start-page: 102 issue: 6947 year: 1994 ident: ref75 article-title: Diagnostic Tests 2: Predictive Values publication-title: BMJ doi: 10.1136/bmj.309.6947.102 – volume: 136 start-page: E359 issue: 5 year: 2015 ident: ref6 article-title: Cancer Incidence and Mortality Worldwide: Sources, Methods and Major Patterns in GLOBOCAN 2012: Globocan 2012 publication-title: Int J Cancer doi: 10.1002/ijc.29210 – volume: 112 start-page: 1503 issue: 7 year: 2008 ident: ref40 article-title: Laser-Induced Autofluorescence Spectral Ratio Reference Standard for Early Discrimination of Oral Cancer publication-title: Cancer doi: 10.1002/cncr.23324 – volume: 33 start-page: 397 issue: 6 year: 2005 ident: ref1 article-title: Strengthening the Prevention of Oral Cancer: The WHO Perspective publication-title: Community Dent Oral Epidemiol doi: 10.1111/j.1600-0528.2005.00251.x – volume: 37 start-page: 477 year: 2001 ident: ref15 article-title: Role of Areca Nut in Betel Quid-Associated Chemical Carcinogenesis: Current Awareness and Future Perspectives publication-title: Oral Oncol doi: 10.1016/S1368-8375(01)00003-3 – volume: 542 start-page: 115 issue: 7639 year: 2017 ident: ref71 article-title: Dermatologist-Level Classification of Skin Cancer with Deep Neural Networks publication-title: Nature doi: 10.1038/nature21056 – volume: 53 start-page: 302 issue: 3 year: 1999 ident: ref39 article-title: Fluorescence Excitation Emission Matrices of Human Tissue: A System for in Vivo Measurement and Method of Data Analysis publication-title: Appl Spectrosc doi: 10.1366/0003702991946695 – volume: 7 start-page: 103 issue: 1 year: 2002 ident: ref24 article-title: Metabolic Effects of the Consumption of Areca Catechu publication-title: Addict Biol doi: 10.1080/13556210120091464 – volume: 35 start-page: 3 issue: 1 year: 2014 ident: ref25 article-title: A Review of the Systemic Adverse Effects of Areca Nut or Betel Nut publication-title: Indian J Med Paediatr Oncol doi: 10.4103/0971-5851.133702 – volume: 3 start-page: 46 year: 1996 ident: ref48 article-title: Porphyrins and the Photodynamic Therapy of Cancer publication-title: Rev Port Quimica – volume: 20 start-page: 5 issue: 1 year: 1993 ident: ref47 article-title: Porphyrins, Porphyrias, Cancer and Photodynamic Therapy—a Model for Carcinogenesis publication-title: J Photochem Photobiol B doi: 10.1016/1011-1344(93)80127-U |
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| SubjectTerms | Applications programs Artificial neural networks Bioengineering Cancer Cancer screening Classification Cloud Computing Computer and Information Sciences Data processing Diagnosis Diagnostic tests Early Detection of Cancer - instrumentation Early Detection of Cancer - methods Electronic mail systems Engineering and Technology Fluorescence Health care Health care costs Health risks Humans Image classification LEDs Lesions Light emitting diodes Low income groups Medical diagnosis Medical economics Medical imaging Medical imaging equipment Medical screening Medicine and Health Sciences Methyltestosterone Mobile Applications Morbidity Mortality Mouth cancer Mouth Neoplasms - diagnosis Neural networks Neural Networks, Computer Optical Imaging Optics Oral cancer Oral cavity Point of care testing Point-of-Care Systems Poverty Remote regions Research funding Security devices Sensitivity and Specificity Smart phones Smartphone - instrumentation Smartphones Spectrum analysis Tobacco White light |
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| Title | Point-of-care, smartphone-based, dual-modality, dual-view, oral cancer screening device with neural network classification for low-resource communities |
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