Incidence and Geographic Distribution of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa

South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that the extensively drug-resistant tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/100,000 (776 cases) in 2011-2012. XD...

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Bibliographic Details
Published in:PloS one Vol. 10; no. 7; p. e0132076
Main Authors: Lim, Jennifer R., Gandhi, Neel R., Mthiyane, Thuli, Mlisana, Koleka, Moodley, Julie, Jaglal, Prenika, Ramdin, Neeshan, Brust, James C. M., Ismail, Nazir, Rustomjee, Roxana, Shah, N. Sarita
Format: Journal Article
Language:English
Published: United States Public Library of Science 06.07.2015
Public Library of Science (PLoS)
Subjects:
Adolescent
Adult
Aged
Antitubercular agents
Child
Child, Preschool
Disease control
Drug resistance
Drug therapy
Drug wholesalers
Epidemics
Extensively Drug-Resistant Tuberculosis - epidemiology
Female
Geographical distribution
Health aspects
Health surveillance
HIV
Human immunodeficiency virus
Humans
Incidence
Infectious diseases
Laboratories
Male
Medical research
Medicine
Microbial drug resistance
Middle Aged
Mortality
Population
Public health
South Africa - epidemiology
Studies
Tuberculosis
South Africa
ISSN:1932-6203, 1932-6203
Online Access:Get full text
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Summary:South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that the extensively drug-resistant tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/100,000 (776 cases) in 2011-2012. XDR-TB cases are widely distributed geographically, with the majority of districts experiencing a rise in incidence.
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Conceived and designed the experiments: NRG JCMB NSS. Performed the experiments: JM NR. Analyzed the data: JRL PJ. Contributed reagents/materials/analysis tools: TM KM NI RR. Wrote the paper: JRL NRG TM KM JCMB RR NSS.
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0132076