Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms

Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial dysbiosis. The study objective was to as...

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Vydáno v:	PloS one Ročník 14; číslo 1; s. e0210064
Hlavní autoři:	Sanctuary, Megan R., Kain, Jennifer N., Chen, Shin Yu, Kalanetra, Karen, Lemay, Danielle G., Rose, Destanie R., Yang, Houa T., Tancredi, Daniel J., German, J. Bruce, Slupsky, Carolyn M., Ashwood, Paul, Mills, David A., Smilowitz, Jennifer T., Angkustsiri, Kathleen
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 09.01.2019 Public Library of Science (PLoS)
Témata:	Abnormalities Animals Autism Autistic children Autistic Disorder - drug therapy Autistic Disorder - physiopathology Biology and Life Sciences Breastfeeding & lactation Cattle Child Child, Preschool Children Children & youth Colostrum Constipation Crossovers Cytokines Diarrhea Dietary supplements Double-Blind Method Dysbacteriosis Female Food science Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - physiopathology Gastrointestinal symptoms Gastrointestinal system Health aspects Humans Interleukin 13 Interleukin-13 - metabolism Intestine Irritable bowel syndrome Male Measles Medicine Medicine and Health Sciences Microbiomes Microbiota Microorganisms Mumps Neurobiology Neurosciences Nutrition research Oligosaccharides Pediatrics Prebiotics Probiotics Probiotics - therapeutic use Reduction Rubella Side effects Social research Social Sciences Supplements Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Sacramento California United States > US California
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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Shrnutí:	Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial dysbiosis. The study objective was to assess tolerability of a probiotic (Bifidobacterium infantis) in combination with a bovine colostrum product (BCP) as a source of prebiotic oligosaccharides and to evaluate GI, microbiome and immune factors in children with ASD and GI co-morbidities. This pilot study is a randomized, double blind, controlled trial of combination treatment (BCP + B. infantis) vs. BCP alone in a cross-over study in children ages 2-11 with ASD and GI co-morbidities (n = 8). This 12-week study included 5 weeks of probiotic-prebiotic supplementation, followed by a two-week washout period, and 5 weeks of prebiotic only supplementation. The primary outcome of tolerability was assessed using validated questionnaires of GI function and atypical behaviors, along with side effects. Results suggest that the combination treatment is well-tolerated in this cohort. The most common side effect was mild gassiness. Some participants on both treatments saw a reduction in the frequency of certain GI symptoms, as well as reduced occurrence of particular aberrant behaviors. Improvement may be explained by a reduction in IL-13 and TNF-α production in some participants. Although limited conclusions can be drawn from this small pilot study, the results support the need for further research into the efficacy of these treatments.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Competing Interests: J. Bruce German and David A Mills are co-founders of Evolve Biosystems, a company focused on diet-based manipulation of the gut microbiota. Evolve Biosystems played no role in the design, execution, interpretation, or publication of this study. This conflict does not alter our adherence to PLOS ONE policies on sharing data and materials. Current address: UC Davis MIND Institute, Sacramento, California, United States of America
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0210064