Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms

Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial dysbiosis. The study objective was to as...

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Veröffentlicht in:PloS one Jg. 14; H. 1; S. e0210064
Hauptverfasser: Sanctuary, Megan R., Kain, Jennifer N., Chen, Shin Yu, Kalanetra, Karen, Lemay, Danielle G., Rose, Destanie R., Yang, Houa T., Tancredi, Daniel J., German, J. Bruce, Slupsky, Carolyn M., Ashwood, Paul, Mills, David A., Smilowitz, Jennifer T., Angkustsiri, Kathleen
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 09.01.2019
Public Library of Science (PLoS)
Schlagworte:
Abnormalities
Animals
Autism
Autistic children
Autistic Disorder - drug therapy
Autistic Disorder - physiopathology
Biology and Life Sciences
Breastfeeding & lactation
Cattle
Child
Child, Preschool
Children
Children & youth
Colostrum
Constipation
Crossovers
Cytokines
Diarrhea
Dietary supplements
Double-Blind Method
Dysbacteriosis
Female
Food science
Gastrointestinal Diseases - drug therapy
Gastrointestinal Diseases - physiopathology
Gastrointestinal symptoms
Gastrointestinal system
Health aspects
Humans
Interleukin 13
Interleukin-13 - metabolism
Intestine
Irritable bowel syndrome
Male
Measles
Medicine
Medicine and Health Sciences
Microbiomes
Microbiota
Microorganisms
Mumps
Neurobiology
Neurosciences
Nutrition research
Oligosaccharides
Pediatrics
Prebiotics
Probiotics
Probiotics - therapeutic use
Reduction
Rubella
Side effects
Social research
Social Sciences
Supplements
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-α
Sacramento California
United States > US
California
ISSN:1932-6203, 1932-6203
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial dysbiosis. The study objective was to assess tolerability of a probiotic (Bifidobacterium infantis) in combination with a bovine colostrum product (BCP) as a source of prebiotic oligosaccharides and to evaluate GI, microbiome and immune factors in children with ASD and GI co-morbidities. This pilot study is a randomized, double blind, controlled trial of combination treatment (BCP + B. infantis) vs. BCP alone in a cross-over study in children ages 2-11 with ASD and GI co-morbidities (n = 8). This 12-week study included 5 weeks of probiotic-prebiotic supplementation, followed by a two-week washout period, and 5 weeks of prebiotic only supplementation. The primary outcome of tolerability was assessed using validated questionnaires of GI function and atypical behaviors, along with side effects. Results suggest that the combination treatment is well-tolerated in this cohort. The most common side effect was mild gassiness. Some participants on both treatments saw a reduction in the frequency of certain GI symptoms, as well as reduced occurrence of particular aberrant behaviors. Improvement may be explained by a reduction in IL-13 and TNF-α production in some participants. Although limited conclusions can be drawn from this small pilot study, the results support the need for further research into the efficacy of these treatments.
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Competing Interests: J. Bruce German and David A Mills are co-founders of Evolve Biosystems, a company focused on diet-based manipulation of the gut microbiota. Evolve Biosystems played no role in the design, execution, interpretation, or publication of this study. This conflict does not alter our adherence to PLOS ONE policies on sharing data and materials.
Current address: UC Davis MIND Institute, Sacramento, California, United States of America
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0210064