Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms
Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial dysbiosis. The study objective was to as...
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| Vydáno v: | PloS one Ročník 14; číslo 1; s. e0210064 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Public Library of Science
09.01.2019
Public Library of Science (PLoS) |
| Témata: | |
| ISSN: | 1932-6203, 1932-6203 |
| On-line přístup: | Získat plný text |
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| Abstract | Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial dysbiosis. The study objective was to assess tolerability of a probiotic (Bifidobacterium infantis) in combination with a bovine colostrum product (BCP) as a source of prebiotic oligosaccharides and to evaluate GI, microbiome and immune factors in children with ASD and GI co-morbidities. This pilot study is a randomized, double blind, controlled trial of combination treatment (BCP + B. infantis) vs. BCP alone in a cross-over study in children ages 2-11 with ASD and GI co-morbidities (n = 8). This 12-week study included 5 weeks of probiotic-prebiotic supplementation, followed by a two-week washout period, and 5 weeks of prebiotic only supplementation. The primary outcome of tolerability was assessed using validated questionnaires of GI function and atypical behaviors, along with side effects. Results suggest that the combination treatment is well-tolerated in this cohort. The most common side effect was mild gassiness. Some participants on both treatments saw a reduction in the frequency of certain GI symptoms, as well as reduced occurrence of particular aberrant behaviors. Improvement may be explained by a reduction in IL-13 and TNF-α production in some participants. Although limited conclusions can be drawn from this small pilot study, the results support the need for further research into the efficacy of these treatments. |
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| AbstractList | Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial dysbiosis. The study objective was to assess tolerability of a probiotic (Bifidobacterium infantis) in combination with a bovine colostrum product (BCP) as a source of prebiotic oligosaccharides and to evaluate GI, microbiome and immune factors in children with ASD and GI co-morbidities. This pilot study is a randomized, double blind, controlled trial of combination treatment (BCP + B. infantis) vs. BCP alone in a cross-over study in children ages 2-11 with ASD and GI co-morbidities (n = 8). This 12-week study included 5 weeks of probiotic-prebiotic supplementation, followed by a two-week washout period, and 5 weeks of prebiotic only supplementation. The primary outcome of tolerability was assessed using validated questionnaires of GI function and atypical behaviors, along with side effects. Results suggest that the combination treatment is well-tolerated in this cohort. The most common side effect was mild gassiness. Some participants on both treatments saw a reduction in the frequency of certain GI symptoms, as well as reduced occurrence of particular aberrant behaviors. Improvement may be explained by a reduction in IL-13 and TNF-α production in some participants. Although limited conclusions can be drawn from this small pilot study, the results support the need for further research into the efficacy of these treatments. Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial dysbiosis. The study objective was to assess tolerability of a probiotic (Bifidobacterium infantis) in combination with a bovine colostrum product (BCP) as a source of prebiotic oligosaccharides and to evaluate GI, microbiome and immune factors in children with ASD and GI co-morbidities. This pilot study is a randomized, double blind, controlled trial of combination treatment (BCP + B. infantis) vs. BCP alone in a cross-over study in children ages 2-11 with ASD and GI co-morbidities (n = 8). This 12-week study included 5 weeks of probiotic-prebiotic supplementation, followed by a two-week washout period, and 5 weeks of prebiotic only supplementation. The primary outcome of tolerability was assessed using validated questionnaires of GI function and atypical behaviors, along with side effects. Results suggest that the combination treatment is well-tolerated in this cohort. The most common side effect was mild gassiness. Some participants on both treatments saw a reduction in the frequency of certain GI symptoms, as well as reduced occurrence of particular aberrant behaviors. Improvement may be explained by a reduction in IL-13 and TNF-[alpha] production in some participants. Although limited conclusions can be drawn from this small pilot study, the results support the need for further research into the efficacy of these treatments. Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial dysbiosis. The study objective was to assess tolerability of a probiotic (Bifidobacterium infantis) in combination with a bovine colostrum product (BCP) as a source of prebiotic oligosaccharides and to evaluate GI, microbiome and immune factors in children with ASD and GI co-morbidities. This pilot study is a randomized, double blind, controlled trial of combination treatment (BCP + B. infantis) vs. BCP alone in a cross-over study in children ages 2-11 with ASD and GI co-morbidities (n = 8). This 12-week study included 5 weeks of probiotic-prebiotic supplementation, followed by a two-week washout period, and 5 weeks of prebiotic only supplementation. The primary outcome of tolerability was assessed using validated questionnaires of GI function and atypical behaviors, along with side effects. Results suggest that the combination treatment is well-tolerated in this cohort. The most common side effect was mild gassiness. Some participants on both treatments saw a reduction in the frequency of certain GI symptoms, as well as reduced occurrence of particular aberrant behaviors. Improvement may be explained by a reduction in IL-13 and TNF-α production in some participants. Although limited conclusions can be drawn from this small pilot study, the results support the need for further research into the efficacy of these treatments.Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial dysbiosis. The study objective was to assess tolerability of a probiotic (Bifidobacterium infantis) in combination with a bovine colostrum product (BCP) as a source of prebiotic oligosaccharides and to evaluate GI, microbiome and immune factors in children with ASD and GI co-morbidities. This pilot study is a randomized, double blind, controlled trial of combination treatment (BCP + B. infantis) vs. BCP alone in a cross-over study in children ages 2-11 with ASD and GI co-morbidities (n = 8). This 12-week study included 5 weeks of probiotic-prebiotic supplementation, followed by a two-week washout period, and 5 weeks of prebiotic only supplementation. The primary outcome of tolerability was assessed using validated questionnaires of GI function and atypical behaviors, along with side effects. Results suggest that the combination treatment is well-tolerated in this cohort. The most common side effect was mild gassiness. Some participants on both treatments saw a reduction in the frequency of certain GI symptoms, as well as reduced occurrence of particular aberrant behaviors. Improvement may be explained by a reduction in IL-13 and TNF-α production in some participants. Although limited conclusions can be drawn from this small pilot study, the results support the need for further research into the efficacy of these treatments. |
| Audience | Academic |
| Author | Kain, Jennifer N. Kalanetra, Karen Ashwood, Paul Slupsky, Carolyn M. Smilowitz, Jennifer T. Yang, Houa T. Sanctuary, Megan R. Mills, David A. Rose, Destanie R. Lemay, Danielle G. Angkustsiri, Kathleen German, J. Bruce Tancredi, Daniel J. Chen, Shin Yu |
| AuthorAffiliation | 3 Department of Food Science and Technology, University of California, Davis, California, United States of America 2 Department of Neurobiology, Physiology and Behavior, University of California, Davis, California, United States of America 1 Department of Nutrition, University of California, Davis, California, United States of America 7 Department of Pediatrics, University of California School of Medicine, Sacramento, California, United States of America TNO, NETHERLANDS 4 USDA ARS Western Human Nutrition Research Center, Davis, California, United States of America 6 MIND Institute, University of California Davis, Sacramento, California, United States of America 8 Foods for Health Institute, University of California, Davis, California, United States of America 5 Genome Center, University of California, Davis, California, United States of America |
| AuthorAffiliation_xml | – name: 5 Genome Center, University of California, Davis, California, United States of America – name: 7 Department of Pediatrics, University of California School of Medicine, Sacramento, California, United States of America – name: 1 Department of Nutrition, University of California, Davis, California, United States of America – name: 6 MIND Institute, University of California Davis, Sacramento, California, United States of America – name: 3 Department of Food Science and Technology, University of California, Davis, California, United States of America – name: 4 USDA ARS Western Human Nutrition Research Center, Davis, California, United States of America – name: TNO, NETHERLANDS – name: 2 Department of Neurobiology, Physiology and Behavior, University of California, Davis, California, United States of America – name: 8 Foods for Health Institute, University of California, Davis, California, United States of America |
| Author_xml | – sequence: 1 givenname: Megan R. surname: Sanctuary fullname: Sanctuary, Megan R. – sequence: 2 givenname: Jennifer N. surname: Kain fullname: Kain, Jennifer N. – sequence: 3 givenname: Shin Yu surname: Chen fullname: Chen, Shin Yu – sequence: 4 givenname: Karen surname: Kalanetra fullname: Kalanetra, Karen – sequence: 5 givenname: Danielle G. surname: Lemay fullname: Lemay, Danielle G. – sequence: 6 givenname: Destanie R. surname: Rose fullname: Rose, Destanie R. – sequence: 7 givenname: Houa T. surname: Yang fullname: Yang, Houa T. – sequence: 8 givenname: Daniel J. orcidid: 0000-0002-3884-7907 surname: Tancredi fullname: Tancredi, Daniel J. – sequence: 9 givenname: J. Bruce surname: German fullname: German, J. Bruce – sequence: 10 givenname: Carolyn M. surname: Slupsky fullname: Slupsky, Carolyn M. – sequence: 11 givenname: Paul surname: Ashwood fullname: Ashwood, Paul – sequence: 12 givenname: David A. surname: Mills fullname: Mills, David A. – sequence: 13 givenname: Jennifer T. surname: Smilowitz fullname: Smilowitz, Jennifer T. – sequence: 14 givenname: Kathleen orcidid: 0000-0001-9769-6638 surname: Angkustsiri fullname: Angkustsiri, Kathleen |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30625189$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | COPYRIGHT 2019 Public Library of Science This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: COPYRIGHT 2019 Public Library of Science – notice: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| DOI | 10.1371/journal.pone.0210064 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Competing Interests: J. Bruce German and David A Mills are co-founders of Evolve Biosystems, a company focused on diet-based manipulation of the gut microbiota. Evolve Biosystems played no role in the design, execution, interpretation, or publication of this study. This conflict does not alter our adherence to PLOS ONE policies on sharing data and materials. Current address: UC Davis MIND Institute, Sacramento, California, United States of America |
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| Title | Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms |
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