High Prevalence of inhA Promoter Mutations among Patients with Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa

Drug-resistant tuberculosis (TB) remains extremely difficult to treat because there are often few remaining active medications and limited diagnostic options to detect resistance. Resistance to isoniazid is typically caused by mutations in either katG or the inhA promoter. inhA mutations confer low-...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 9; p. e0135003
Main Authors:	Niehaus, Abraham J., Mlisana, Koleka, Gandhi, Neel R., Mathema, Barun, Brust, James C. M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 02.09.2015 Public Library of Science (PLoS)
Subjects:	Antibiotics Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Bacterial Proteins - genetics Catalase - genetics Clinical outcomes Cross-resistance Demographic aspects Diagnostic systems Drug dosages Drug resistance Drug therapy Epidemiology Ethionamide Ethionamide - pharmacology Ethionamide - therapeutic use Extensively Drug-Resistant Tuberculosis - drug therapy Extensively Drug-Resistant Tuberculosis - epidemiology Extensively Drug-Resistant Tuberculosis - microbiology Gene mutation Genes Genetic aspects Humans Isoniazid Isoniazid - pharmacology Isoniazid - therapeutic use Laboratories Medical diagnosis Medicine Microbial drug resistance Multidrug resistant organisms Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Oxidoreductases - genetics Patients Physiological aspects Prevalence Prevalence studies (Epidemiology) Promoter Regions, Genetic Public health South Africa - epidemiology Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - microbiology South Africa United States New York United States > US
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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