Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study

Fibroblast growth factor 23 is an emerging vascular biomarker, recently associated with cerebral small vessel disease and poor cognition in patients on dialysis. It also interacts with klotho, an anti-aging and cognition enhancing protein. To determine if circulating Fibroblast growth factor 23 (FGF...

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Vydáno v:	PloS one Ročník 14; číslo 3; s. e0213321
Hlavní autoři:	McGrath, Emer R., Himali, Jayandra J., Levy, Daniel, Conner, Sarah C., Pase, Matthew P., Abraham, Carmela R., Courchesne, Paul, Satizabal, Claudia L., Vasan, Ramachandran S., Beiser, Alexa S., Seshadri, Sudha
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 04.03.2019 Public Library of Science (PLoS)
Témata:	Adults Advertising executives Aged Aging Alzheimer Disease - blood Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer's disease Analysis Antihypertensives Apolipoprotein E Apolipoproteins Biology and Life Sciences Biomarkers Biomarkers - blood Blood Pressure Brain Cardiovascular diseases Cognition Cognition & reasoning Cognitive ability Dementia Dementia - blood Dementia - diagnosis Dementia - epidemiology Dementia disorders Diabetes mellitus Dialysis Disease Epidermal growth factor receptors Female Fibroblast Growth Factor-23 Fibroblast growth factors Fibroblast Growth Factors - blood Fibroblasts Growth factors Hazards Health risk assessment Health sciences Heart Humans Incidence Klotho protein Longitudinal Studies Magnetic resonance imaging Male Measurement methods Medicine Medicine and Health Sciences Metabolism Offspring Older people Physical sciences Physiology Population Prospective Studies Proteins Public health Regression analysis Renal function Risk Risk Factors Smoking United States - epidemiology Vascular diseases Vitamin deficiency United States United States > US
ISSN:	1932-6203, 1932-6203
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Shrnutí:	Fibroblast growth factor 23 is an emerging vascular biomarker, recently associated with cerebral small vessel disease and poor cognition in patients on dialysis. It also interacts with klotho, an anti-aging and cognition enhancing protein. To determine if circulating Fibroblast growth factor 23 (FGF23) is associated with new-onset cognitive outcomes in a community-based cohort of cognitively healthy adults with long-term follow-up. We measured serum FGF23 levels in 1537 [53% women, mean age 68.7 (SD 5.7)] dementia-free Framingham Offspring participants at their 7th quadrennial examination (1998-2001), and followed these participants for the development of clinical all-cause dementia and Alzheimer's disease (AD). Secondary outcomes included MRI-based structural brain measures, and neurocognitive test performance at exam 7. During a median (Q1, Q3) 12-year (7.0, 13.3) follow up, 122 (7.9%) participants developed dementia, of whom 91 (5.9%) had AD. Proportional-hazards regression analysis, adjusted for age, sex, education, systolic blood pressure, antihypertensive medication, prevalent cardiovascular disease, diabetes mellitus, smoking status and apoE ε4 carrier status, revealed that higher serum FGF23 levels were associated with an increased risk of incident dementia and AD (Hazard ratio [HR] per 1 standard deviation increment in inverse transformed FGF23 level 1.25, 95% CI 1.02-1.53, and 1.32, 95% CI 1.04-1.69, respectively). There was no significant interaction according to presence/absence of significant renal impairment (eGFR <30 versus ≥30ml/min) and risk of dementia (based on 1537; p = 0.97). Higher circulating FGF23 is associated with an increased risk of dementia, suggesting that FGF23-related biological pathways may play a role in the development of dementia.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0213321