Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation

Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 4; p. e0175278
Main Authors:	Miranda, Pryscila, Gil-Santana, Leonardo, Oliveira, Marina G., Mesquita, Eliene D. D., Silva, Elisangela, Rauwerdink, Anneloek, Cobelens, Frank, Oliveira, Martha M., Andrade, Bruno B., Kritski, Afrânio
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 06.04.2017 Public Library of Science (PLoS)
Subjects:	Acute phase proteins Acute phase substances Adult Alcoholism Anemia Animal models Antibodies Antiinfectives and antibacterials Antitubercular Agents - therapeutic use Ascorbic acid Attenuation Autoimmune diseases Bacilli Bacteria Biochemistry Biology and Life Sciences Biomarkers Biotechnology Bone marrow Bone marrow transplantation C-reactive protein C-Reactive Protein - metabolism Cages Care and treatment Carotene Cell culture Cell survival Chemotherapy Clinical outcomes Clinical trials Decontamination Diagnosis Digestion Drug abuse Drug resistance Female Ferritin Ferritins - metabolism Genetic aspects Health aspects Health risk assessment HIV Homeostasis Human immunodeficiency virus Humans Infections Inflammation Interferon Interleukin 1 Loads (forces) Lung diseases Male Malignancy Medicine and Health Sciences Middle Aged Mortality Patients Proteins Psychiatry Tuberculosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - metabolism Vitamin E Brazil Rio de Janeiro Brazil
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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