Inflammation and Prolonged QT Time: Results from the Cardiovascular Disease, Living and Ageing in Halle (CARLA) Study

Previous research found an association of CRP with QT time in population based samples. Even more, there is evidence of a substantial involvement of the tumor necrosis factor-alpha system in the pathophysiology of cardiac arrhythmia, while the role of Interleukin 6 remains inconclusive. To determine...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	PloS one Ročník 9; číslo 4; s. e95994
Hlavní autori:	Medenwald, Daniel, Kors, Jan A., Loppnow, Harald, Thiery, Joachim, Kluttig, Alexander, Nuding, Sebastian, Tiller, Daniel, Greiser, Karin H., Werdan, Karl, Haerting, Johannes
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 01.04.2014 Public Library of Science (PLoS)
Predmet:	Aged Aged, 80 and over Aging Alcohol use Analysis Arrhythmia Arrhythmias, Cardiac - blood Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - immunology Arrhythmias, Cardiac - physiopathology Atrial fibrillation Biology and Life Sciences Brugada Syndrome C-reactive protein Cardiac arrhythmia Cardiac Conduction System Disease Cardiovascular diseases Care and treatment Confidence intervals Cross-Sectional Studies EKG Electrocardiogram Electrocardiography Female Fibrillation Gender aspects Geriatrics Germany Health aspects Heart Conduction System - abnormalities Heart Conduction System - immunology Heart Conduction System - physiopathology Heart diseases Heart Rate Humans Inflammation Mediators - blood Interleukin Interleukin 6 Interleukin-6 - blood Linear Models Male Medicine and Health Sciences Men Middle Aged Older people Parameter sensitivity Receptors, Tumor Necrosis Factor, Type I - blood Regression analysis Research and Analysis Methods Risk factors Sex differences Statistical analysis Studies Tumor necrosis factor Tumor Necrosis Factor-alpha - physiology Tumor necrosis factor-TNF Tumor necrosis factor-α Urban Population Germany
ISSN:	1932-6203, 1932-6203
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	Previous research found an association of CRP with QT time in population based samples. Even more, there is evidence of a substantial involvement of the tumor necrosis factor-alpha system in the pathophysiology of cardiac arrhythmia, while the role of Interleukin 6 remains inconclusive. To determine the association between inflammation with an abnormally prolonged QT-time (APQT) in men and women of the elderly general population. Data descend from the baseline examination of the prospective, population-based Cardiovascular Disease, Living and Ageing in Halle (CARLA) Study. After exclusion of subjects with atrial fibrillation and missing ECG recording the final study cohort consisted of 919 men and 797 women. Blood parameters of inflammation were the soluble TNF-Receptor 1 (sTNF-R1), the high-sensitive C-reactive protein (hsCRP), and Interleukin 6 (IL-6). In accordance with major cardiologic societies we defined an APQT above a QT time of 460 ms in women and 450 ms in men. Effect sizes and the corresponding 95% confidence intervals (CI) were estimated by performing multiple linear and logistic regression analyses including the analysis of sex differences by interaction terms. After covariate adjustment we found an odds ratio (OR) of 1.89 (95% CI: 1.13, 3.17) per 1000 pg/mL increase of sTNF-R1 in women, and 0.74 (95% CI: 0.48, 1.15) in men. In the covariate adjusted linear regression sTNF-R1 was again positively associated with QT time in women (5.75 ms per 1000 pg/mL, 95% CI: 1.32, 10.18), but not in men. Taking possible confounders into account IL-6 and hsCRP were not significantly related to APQT in both sexes. Our findings from cross-sectional analyses give evidence for an involvement of TNF-alpha in the pathology of APQT in women.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Analyzed the data: DM. Contributed reagents/materials/analysis tools: HL. Wrote the paper: DM. The analysis of blood samples mainly the analysis of C-reactive protein blood levels: JT. Played a key role in the planing and conduction of the study, and revised the manuscript critically for important intellectual content: AK. Measured the plasma parameters: JT. Participated in the realisation of the study: DM JAK HL JT AK SN DT KHG KW JH. Gave comments: DT AK KHG JK KW JH. Analysed the ECGs: SN. Performed the statistical analyses: DM. Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0095994