Displacement of the Predominant Dengue Virus from Type 2 to Type 1 with a Subsequent Genotype Shift from IV to I in Surabaya, Indonesia 2008–2010

Indonesia has annually experienced approximately 100,000 reported cases of dengue fever (DF) and dengue hemorrhagic fever (DHF) in recent years. However, epidemiological surveys of dengue viruses (DENVs) have been limited in this country. In Surabaya, the second largest city, a single report indicat...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:PloS one Ročník 6; číslo 11; s. e27322
Hlavní autori: Yamanaka, Atsushi, Mulyatno, Kris C., Susilowati, Helen, Hendrianto, Eryk, Ginting, Amor P., Sary, Dian D., Rantam, Fedik A., Soegijanto, Soegeng, Konishi, Eiji
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Public Library of Science 07.11.2011
Public Library of Science (PLoS)
Predmet:
Analysis
Animals
Aquatic insects
Base Sequence
Biology
Culicidae - virology
Data Collection
Dengue - epidemiology
Dengue - virology
Dengue fever
Dengue hemorrhagic fever
Dengue virus
Dengue Virus - genetics
Dengue Virus - isolation & purification
Env gene
Epidemics
Epidemiology
Fever
Gene sequencing
Genetic aspects
Genotype
Hemorrhagic fevers
Humans
Indonesia - epidemiology
Medical schools
Medicine
Mosquitoes
Phylogeny
Polls & surveys
Polymerase Chain Reaction
Severe Dengue - epidemiology
Severe Dengue - virology
Studies
Surveys
Tropical diseases
Vector-borne diseases
Viral diseases
Viruses
Indonesia
Surabaya Indonesia
Thailand
Japan
Bangkok Thailand
ISSN:1932-6203, 1932-6203
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Indonesia has annually experienced approximately 100,000 reported cases of dengue fever (DF) and dengue hemorrhagic fever (DHF) in recent years. However, epidemiological surveys of dengue viruses (DENVs) have been limited in this country. In Surabaya, the second largest city, a single report indicated that dengue virus type 2 (DENV2) was the predominant circulating virus in 2003-2005. We conducted three surveys in Surabaya during: (i) April 2007, (ii) June 2008 to April 2009, and (iii) September 2009 to December 2010. A total of 231 isolates were obtained from dengue patients and examined by PCR typing. We found that the predominant DENV shifted from type 2 to type 1 between October and November 2008. Another survey using wild-caught mosquitoes in April 2009 confirmed that dengue type 1 virus (DENV1) was the predominant type in Surabaya. Phylogenetic analyses of the nucleotide sequences of the complete envelope gene of DENV1 indicated that all 22 selected isolates in the second survey belonged to genotype IV and all 17 selected isolates in the third survey belonged to genotype I, indicating a genotype shift between April and September 2009. Furthermore, in December 2010, isolates were grouped into a new clade of DENV1 genotype I, suggesting clade shift between September and December 2010. According to statistics reported by the Surabaya Health Office, the proportion of DHF cases among the total number of dengue cases increased about three times after the type shift in 2008. In addition, the subsequent genotype shift in 2009 was associated with the increased number of total dengue cases. This indicates the need for continuous surveillance of circulating viruses to predict the risk of DHF and DF.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Conceived and designed the experiments: AY EK. Performed the experiments: AY KCM HS EH. Analyzed the data: AY EK. Contributed reagents/materials/analysis tools: APG DDS FAR SS. Wrote the paper: AY EK.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0027322