Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41

A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody response to the transiently exposed MPER pre-hairpin intermediate neutralization epitope. Here we describe a HIV-1 envelope (Env) gp140 oligomer...

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Bibliographic Details
Published in:	PloS one Vol. 6; no. 11; p. e27824
Main Authors:	Dennison, S. Moses, Sutherland, Laura L., Jaeger, Frederick H., Anasti, Kara M., Parks, Robert, Stewart, Shelley, Bowman, Cindy, Xia, Shi-Mao, Zhang, Ruijun, Shen, Xiaoying, Scearce, Richard M., Ofek, Gilad, Yang, Yongping, Kwong, Peter D., Santra, Sampa, Liao, Hua-Xin, Tomaras, Georgia, Letvin, Norman L., Chen, Bing, Alam, S. Munir, Haynes, Barton F.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 30.11.2011 Public Library of Science (PLoS)
Subjects:	Animals Antibodies Antibody Formation - immunology Antibody response Antibody Specificity - immunology Antigenic determinants Antigens B cells Binding sites Biology Children & youth Cross-Priming - immunology Deoxyribonucleic acid DNA Epitopes Epitopes - immunology Fusion protein Glycoprotein gp41 Glycoproteins Guinea Pigs HIV HIV Antibodies - blood HIV Antibodies - immunology HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - immunology HIV-1 - immunology Hospitals Human immunodeficiency virus Immunization Immunoglobulins Infections Infectious diseases Lipids Liposomes Liposomes - chemistry Macaca mulatta - immunology Medicine Neutralization Neutralization Tests Neutralizing Peptides Peptides - chemistry Peptides - immunology Physicians Protein binding Protein Structure, Quaternary Proteins Recombinant Fusion Proteins - metabolism Scaffolds Strategy Well construction Yang, Cindy North Carolina United States > US Maryland Massachusetts
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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