Canadian Valuation of EQ-5D Health States: Preliminary Value Set and Considerations for Future Valuation Studies

The EQ-5D is a preference based instrument which provides a description of a respondent's health status, and an empirically derived value for that health state often from a representative sample of the general population. It is commonly used to derive Quality Adjusted Life Year calculations (QA...

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Bibliographic Details
Published in:PloS one Vol. 7; no. 2; p. e31115
Main Authors: Bansback, Nick, Tsuchiya, Aki, Brazier, John, Anis, Aslam
Format: Journal Article
Language:English
Published: United States Public Library of Science 06.02.2012
Public Library of Science (PLoS)
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Analysis
Canada
Classification
Demographics
Demography
Experiments
Feasibility studies
Female
Health economics
Health Status
Humans
Male
Medicine
Middle Aged
Population
Preferences
Public health
Quality-Adjusted Life Years
Quebec
Recruitment
Sensitivity analysis
Social and Behavioral Sciences
Surveys
Valuation
Values
Young Adult
Canada
Quebec
United Kingdom > UK
Vancouver British Columbia Canada
ISSN:1932-6203, 1932-6203
Online Access:Get full text
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Summary:The EQ-5D is a preference based instrument which provides a description of a respondent's health status, and an empirically derived value for that health state often from a representative sample of the general population. It is commonly used to derive Quality Adjusted Life Year calculations (QALY) in economic evaluations. However, values for health states have been found to differ between countries. The objective of this study was to develop a set of values for the EQ-5D health states for use in Canada. Values for 48 different EQ-5D health states were elicited using the Time Trade Off (TTO) via a web survey in English. A random effect model was fitted to the data to estimate values for all 243 health states of the EQ-5D. Various model specifications were explored. Comparisons with EQ-5D values from the UK and US were made. Sensitivity analysis explored different transformations of values worse than dead, and exclusion criteria of subjects. The final model was estimated from the values of 1145 subjects with socio-demographics broadly representative of Canadian general population with the exception of Quebec. This yielded a good fit with observed TTO values, with an overall R2 of 0.403 and a mean absolute error of 0.044. A preference-weight algorithm for Canadian studies that include the EQ-5D is developed. The primary limitations regarded the representativeness of the final sample, given the language used (English only), the method of recruitment, and the difficulty in the task. Insights into potential issues for conducting valuation studies in countries as large and diverse as Canada are gained.
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Conceived and designed the experiments: NB JB AT AA. Performed the experiments: NB JB AT AA. Analyzed the data: NB. Contributed reagents/materials/analysis tools: NB JB AT AA. Wrote the paper: NB JB AT AA.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0031115