Lysine Residue 185 of Rad1 Is a Topological but Not a Functional Counterpart of Lysine Residue 164 of PCNA

Monoubiquitylation of the homotrimeric DNA sliding clamp PCNA at lysine residue 164 (PCNA(K164)) is a highly conserved, DNA damage-inducible process that is mediated by the E2/E3 complex Rad6/Rad18. This ubiquitylation event recruits translesion synthesis (TLS) polymerases capable of replicating acr...

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Vydáno v:	PloS one Ročník 6; číslo 1; s. e16669
Hlavní autoři:	Wit, Niek, Krijger, Peter H. L., van den Berk, Paul C. M., Jacobs, Heinz
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 31.01.2011 Public Library of Science (PLoS)
Témata:	Animals B cells Baking yeast Biology Cancer Cell cycle Cell growth Chemical synthesis CHK1 protein Class switching Crystal structure Cytokines Deoxyribonucleic acid DNA DNA Damage DNA polymerases Exonucleases - physiology Genes Hus1 protein Immunoglobulins Immunology Lysine Lysine - physiology Mammals Mice Models, Animal Mutation Proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - physiology Protein Processing, Post-Translational Rad1 protein Rad9 protein Recombination Replication Residues Saccharomyces cerevisiae Senescence Sliding Somatic hypermutation Ubiquitin Yeast Netherlands
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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