Defective CFTR Expression and Function Are Detectable in Blood Monocytes: Development of a New Blood Test for Cystic Fibrosis

Evaluation of cystic fibrosis transmembrane conductance regulator (CFTR) functional activity to assess new therapies and define diagnosis of cystic fibrosis (CF) is cumbersome. It is known that leukocytes express detectable levels of CFTR but the molecule has not been characterized in these cells. I...

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Vydáno v:	PloS one Ročník 6; číslo 7; s. e22212
Hlavní autoři:	Sorio, Claudio, Buffelli, Mario, Angiari, Chiara, Ettorre, Michele, Johansson, Jan, Vezzalini, Marzia, Viviani, Laura, Ricciardi, Mario, Verzè, Genny, Assael, Baroukh Maurice, Melotti, Paola
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 21.07.2011 Public Library of Science (PLoS)
Témata:	Adolescent Adult Aged Algorithms Amiloride - pharmacology Biology Blood Blood tests Cell Line Child Child, Preschool Chloride Clinical trials Conductance Cystic fibrosis Cystic Fibrosis - blood Cystic Fibrosis - diagnosis Cystic Fibrosis - physiopathology Cystic Fibrosis Transmembrane Conductance Regulator - blood Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Depolarization Diagnosis Diagnostic systems Drug development Epithelial Cells - drug effects Epithelial Cells - metabolism Evaluation Female Fibrosis Fluorescence Genetic counseling Genotype & phenotype Hematologic Tests - methods Heterozygote Humans Immunofluorescence Indexing Infant Kinases Leukocytes Male Medical research Medicine Membrane potential Membrane Potentials - drug effects Middle Aged Monocytes Monocytes - drug effects Monocytes - metabolism Mutation Older people Patients Peripheral blood Phenotype Physiology Protein kinase A Pseudomonas aeruginosa Resistance Single-Cell Analysis White blood cells Young Adult Italy
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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